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Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays.
Open accessAbstract
Anti-acetylcholine receptor (AChR) antibody was undetectable in 26/153 (17%) sera from myasthenia gravis patients assayed by standard RIA using human acetylcholine receptor. Eight of these were found to be positive with a modified protocol using a mixture of normal and denervated AChR, reducing the proportion of "negative" sera to 12%. Many of these were from patients with a short history; two such patients later developed low positive values. Anti-AChR without clinical evidence of myasthenia was found in one of three monozygotic twins of myasthenia gravis patients, and in one of thirty other first degree relatives of a further 17 patients. Anti-AChR is a valuable and highly specific diagnostic test which, with the assay used here, is positive in about 88% of patients with clinical features of myasthenia gravis.
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Citations
Cited by
Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
Meriggioli, M. N., & Sanders, D. B. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70063-8 · Cited by 894
Howard, J. F., Utsugisawa, K., Benatar, M., Murai, H., Barohn, R. J., Illa, I., Jacob, S., Vissing, J., Burns, T. M., Kissel, J. T., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30369-1 · Cited by 845
Potassium channel antibodies in two patients with reversible limbic encephalitis
Buckley, C., Oger, J., Clover, L., Tüzün, E., Carpenter, K., Jackson, M., & Vincent, A. (2001) · Annals of Neurology · doi:10.1002/ana.1097 · Cited by 444
Self-citationDiagnostic and clinical classification of autoimmune myasthenia gravis
Berrih-Aknin, S., Frenkian-Cuvelier, M., & Eymard, B. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.01.003 · Cited by 289
Acetylcholine receptors and myasthenia
Lindstrom, J. M. (2000) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(200004)23:4<453::aid-mus3>3.0.co;2-o · Cited by 280
Metadata
- Authors
- Vincent, A., & Newsom-Davis, J.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1985-12-01
- Volume
- 48
- Issue
- 12
- Pages
- 1246-1252
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2146831407
- Cited by
- 471
- References
- 0
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vincent, A., & Newsom-Davis, J. (1985). Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.48.12.1246
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