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Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia
Open accessAbstract
The cornu ammonis 1 region of the hippocampus (CA1) sector of hippocampus is vulnerable to both Alzheimer's disease (AD)-type neurofibrillary degeneration and anoxia-ischemia. The objective of this article is to compare number and size of neurons in CA1 in AD versus ischemic vascular dementia. Unbiased stereological methods were used to estimate the number and volume of neurons in 28 autopsy-derived brain samples. For each case, the entire hippocampus from one cerebral hemisphere was sliced into 5mm slabs (5-7 slabs/case), cut into 50 microm sections, and stained with gallocyanine. Using the optical dissector, we systematically sampled the number and size of neurons throughout the extent of CA1 and CA2. The total number of neurons was significantly less in AD compared with ischemic vascular dementia (p < 0.02), but there was no significant difference in neuron size. The greatest loss of neurons was observed in two cases with combined AD and hippocampal sclerosis. Regardless of causative diagnosis, the number of CA1 neurons correlates with magnetic resonance imaging-derived hippocampal volume (r = 0.72; p < 0.001) and memory score (r = 0.62; p < 0.01). We conclude that although CA1 neuron loss is more consistently observed in AD than ischemic vascular dementia, severity of loss shows the expected correlation with structure and function across causative subtype. Reductions in magnetic resonance imaging-derived hippocampal volume reflect loss, rather than shrinkage, of CA1 neurons.
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Metadata
- Authors
- Zarow, C., Vinters, H. V., Ellis, W. G., Weiner, M. W., Mungas, D., White, L., & Chui, H. C.
- Affiliations
- University of Southern California (US)
- University of California, Los Angeles (US)
- University of California Davis Medical Center (US)
- University of California, San Francisco (US)
- University of California, Davis (US)
- Kuakini Medical Center (US)
- Corresponding author
- Zarow, Chris
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2005-05-31
- Volume
- 57
- Issue
- 6
- Pages
- 896-903
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC1851673
- OpenAlex
- W2106775021
- Cited by
- 241
- References
- 26
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 11 · 2020: 23 · 2019: 10 · 2018: 10 · 2017: 16 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 19 · 2012: 8
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG016570, P50-AG 16570, 1P01 AG12435, R01AG017155, R01AG010897, 1-R01-AG17155, P01AG012435)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, cornu ammonis 1, neuronal loss, neuron size, hippocampal volume, hippocampal sclerosis, neurofibrillary degeneration, stereology
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Brain Ischemia, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Neurons, Neuropsychological Tests, Prospective Studies, Dementia, Vascular, Lewy Bodies
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