Cited by 241Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia

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Zarow, Chris, Vinters, Harry V., Ellis, William G., Weiner, Michael W., Mungas, Dan, White, Lon, Chui, Helena C.·2005·Annals of Neurology

DOI 10.1002/ana.20503PMC PMC1851673

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Abstract

The cornu ammonis 1 region of the hippocampus (CA1) sector of hippocampus is vulnerable to both Alzheimer's disease (AD)-type neurofibrillary degeneration and anoxia-ischemia. The objective of this article is to compare number and size of neurons in CA1 in AD versus ischemic vascular dementia. Unbiased stereological methods were used to estimate the number and volume of neurons in 28 autopsy-derived brain samples. For each case, the entire hippocampus from one cerebral hemisphere was sliced into 5mm slabs (5-7 slabs/case), cut into 50 microm sections, and stained with gallocyanine. Using the optical dissector, we systematically sampled the number and size of neurons throughout the extent of CA1 and CA2. The total number of neurons was significantly less in AD compared with ischemic vascular dementia (p < 0.02), but there was no significant difference in neuron size. The greatest loss of neurons was observed in two cases with combined AD and hippocampal sclerosis. Regardless of causative diagnosis, the number of CA1 neurons correlates with magnetic resonance imaging-derived hippocampal volume (r = 0.72; p < 0.001) and memory score (r = 0.62; p < 0.01). We conclude that although CA1 neuron loss is more consistently observed in AD than ischemic vascular dementia, severity of loss shows the expected correlation with structure and function across causative subtype. Reductions in magnetic resonance imaging-derived hippocampal volume reflect loss, rather than shrinkage, of CA1 neurons.

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“Medial temporal lobe and hippocampal atrophy are associated with VaD(14,153) and SVD(154,155) even in the absence of ischemic injury.(156,157) The loss of CA1 neurons in ischemic VaD is linked to lower hippocampal volume and memory score,(157) but the degree of loss appears less in VaD than in AD.”
Background
Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease
Yan, J., Liu, X.-H., Han, M., Wang, Y., Sun, X., Yu, N., Li, T., Su, B., & Chen, Z.-Y. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.005 · Cited by 126
A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats
Duffy, K. B., Spangler, E. L., Devan, B. D., Guo, Z., Bowker, J. L., Janas, A. M., Hagepanos, A., Minor, R. K., de Cabo, R., Mouton, P. R., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.002 · Cited by 124
The Seed Extract of Cassia obtusifolia Ameliorates Learning and Memory Impairments Induced by Scopolamine or Transient Cerebral Hypoperfusion in Mice
Kim, D. H., Yoon, B. H., Kim, Y.-W., Lee, S.-J., Shin, B. Y., Jung, J. W., Kim, H. J., Lee, Y. S., Choi, J. S., Kim, S. Y., et al. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0061565 · Cited by 120
Serial MRI and CSF biomarkers in normal aging, MCI, and AD
Vemuri, P., Wiste, H. J., Weigand, S. D., Knopman, D. S., Trojanowski, J. Q., Shaw, L. M., Bernstein, M. A., Aisen, P. S., Weiner, M., Petersen, R. C., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e7ca82 · Cited by 154
Self-citation
Hippocampal shape analysis in Alzheimer’s disease: A population-based study
Scher, I., Xu, Y., Korf, E. S. C., White, L. R., Scheltens, P., Toga, A. W., Thompson, P. M., Hartley, S. W., Witter, M. P., Valentino, D. J., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.036 · Cited by 117
Self-citation
Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND
Vemuri, P., Simon, G., Kantarci, K., Whitwell, J. L., Senjem, M. L., Przybelski, S. A., Gunter, J. L., Josephs, K. A., Knopman, D. S., Boeve, B. F., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.073 · Cited by 108
“…MRI measures macroscopic brain anatomy by capturing the regional variations in gray matter (GM) atrophy that is typically related to loss of neurons, synapses, and dendritic dearborization that occurs on a microscopic level in neurodegenerative diseases (Bobinski et al., 2000; Zarow et al., 2005).”
Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical A lzheimer's disease
Soldan, A., Pettigrew, C. A., Lu, Y., Wang, M., Selnes, O. A., Albert, M., Brown, T., Ratnanather, J. T., Laurent Younes, B., & Miller, M. I. (2015) · Human Brain Mapping · doi:10.1002/hbm.22810 · Cited by 116
“Atrophy of MTL regions, as measured by MRI, is thought reflect tau-related neuronal injury, one of the hallmarks of AD [Bobinski et al., 2000; Jack et al., 2002; Whitwell et al., 2008; Zarow et al., 2005].”
Modeling the Role of the Glymphatic Pathway and Cerebral Blood Vessel Properties in Alzheimer’s Disease Pathogenesis
Kyrtsos, C. R., & Baras, J. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139574 · Cited by 108
Understanding hippocampal sclerosis in the elderly: Epidemiology, characterization, and diagnostic issues
Zarow, C., Sitzer, T. E., & Chui, H. C. (2008) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-008-0057-3 · Cited by 104
Self-citation
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition
Murley, A. G., Rouse, M. A., Jones, P. S., Ye, R., Hezemans, F. H., O’Callaghan, C., Frangou, P., Kourtzi, Z., Rua, C., Carpenter, T. A., et al. (2020) · Brain · doi:10.1093/brain/awaa305 · Cited by 104
Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration
Amador, C., Ahmed, Z., Zehr, C., & Dickson, D. W. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0183-4 · Cited by 100
“, cardiorespiratory failure) or cerebrovascular disease [8, 36].”
Background
Effects of acetylcholinesterase inhibitors and memantine on resting-state electroencephalographic rhythms in Alzheimer’s disease patients
Babiloni, C., Percio, C. D., Bordet, R., Bourriez, J., Bentivoglio, M., Payoux, P., Derambure, P., Dix, S. L., Infarinato, F., Lizio, R., et al. (2012) · Clinical Neurophysiology · doi:10.1016/j.clinph.2012.09.017 · Cited by 101
“On the other hand, the validated neuroimaging biomarkers include structural MRI to probe neurodegeneration as revealed by hippocampal atrophy (Frisoni et al., 2010; Silbert et al., 2003; Zarow et al., 2005; Schuff et al., 2009; Van de Pol et al., 2006) and resting-state PET-fluoro-deoxy-glucose (FDG) mapping of tempor…”
Background
Cortical Sources of Resting State EEG Rhythms are Sensitive to the Progression of Early Stage Alzheimer's Disease
Babiloni, C., Lizio, R., Percio, C. D., Marzano, N., Soricelli, A., Salvatore, E., Ferri, R., Cosentino, F., Tedeschi, G., Montella, P., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121750 · Cited by 102
“Furthermore, PET-amyloid Pittsburg Compound (cid:1) deposition in the brain of AD patients [15–17].”
Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain
Kobayashi, E., Nakano, M., Kubota, K., Himuro, N., Mizoguchi, S., Chikenji, T., Otani, M., Mizue, Y., Nagaishi, K., & Fujimiya, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-19442-7 · Cited by 98
Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease
Tarawneh, R. M., Head, D. M., Allison, S. L., Buckles, V., Fagan, A. M., Ladenson, J. H., Morris, J. C., & Holtzman, D. M. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0202 · Cited by 99
Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
Chornenkyy, Y., Fardo, D. W., & Nelson, P. T. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0196-y · Cited by 93
Caspase-8 in inflammatory diseases: a potential therapeutic target
Zhang, W., Zhu, C., Liao, Y., Zhou, M., Xu, W., & Zou, Z. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00646-x · Cited by 108
Review: Vascular dementia: clinicopathologic and genetic considerations
Vinters, H. V., Zarow, C., Borys, E., Whitman, J. D., Tung, S., Ellis, W. G., Zheng, L., & Chui, H. C. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12472 · Cited by 90
Self-citation
Hydrogen Sulfide Attenuates Neuronal Injury Induced by Vascular Dementia Via Inhibiting Apoptosis in Rats
Zhang, L., Jiang, C.-X., & Liu, D. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0006-9 · Cited by 89
“Many studies have demonstrated that cerebral ischemia can produce cognitive deficit and neuronal damage [ 33 ].”
Background
Hippocampal volume is an independent predictor of cognitive performance in CADASIL
O'Sullivan, M., Ngo, E., Viswanathan, A., Jouvent, E., Gschwendtner, A., Saemann, P. G., Duering, M., Pachai, C., Bousser, M.-G., Chabriat, H., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.09.002 · Cited by 85
PART and SNAP
Jack, C. R. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1362-3 · Cited by 93
“These are well known to pathologists and include hippocampal sclerosis [15, 29, 33, 45], frontotemporal lobar degeneration (especially with TDP43 pathology [42]), argyrophilic grain disease, and ischemia/ anoxia [7].”
Background
Potential Therapeutics for Vascular Cognitive Impairment and Dementia
Sun, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171016164734 · Cited by 87
“The neuronal count, for instance, in the hippocampal CA1 subregion has been found not to differ in VaD patients from that of control subjects [52].”
Result
Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects
Apostolova, L. G., Morra, J. H., Green, A. E., Hwang, K., Avedissian, C., Woo, E., Cummings, J. L., Toga, A. W., Jack, C. R., Weiner, M. W., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.125 · Cited by 87
“It is one of the first regions to be affected and throughout the disease course consistently shows the highest pathology burden (Bobinski et al., 1997, 1995; Schonheit et al., 2004; Zarow et al., 2005).”
Self-citation
Hippocampal Volumes, Proton Magnetic Resonance Spectroscopy Metabolites, and Cerebrovascular Disease in Mild Cognitive Impairment Subtypes
Kantarci, K., Petersen, R. C., Przybelski, S. A., Weigand, S. D., Shiung, M. M., Whitwell, J. L., Negash, S., Ivnik, R. J., Boeve, B. F., Knopman, D. S., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.12.1621 · Cited by 84
Dementia and Cerebrovascular Disease
Knopman, D. S. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.2.223 · Cited by 82
Relationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC‐ADNI Harmonized Hippocampal Segmentation Protocol
Apostolova, L. G., Zarow, C., Biado, K., Hurtz, S., Boccardi, M., Somme, J. H., Honarpisheh, H., Blanken, A. E., Brook, J. K., Tung, S., et al. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.01.001 · Cited by 77
“In addition we also report that the mean neuronal count of the subiculum, CA1 and CA4 correlate with EADC-ADNI HarP defined hippocampal volume, which is in agreement with our previous work [36].”
Self-citation
Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies
Lunnon, K., & Mill, J. (2013) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32201 · Cited by 78
“, 2011], AD is by definition characterized by progressive changes in the abundance and function of specific brain cells, particularly in the hippocampus with where there is selective neuronal cell loss [West et al., 1994; Zarow et al., 2005], the activation of glia [Meda et al.”
Protein contributions to brain atrophy acceleration in Alzheimer’s disease and primary age-related tauopathy
Josephs, K. A., Martin, P. R., Weigand, S. D., Tosakulwong, N., Buciuc, M., Murray, M. E., Petrucelli, L., Senjem, M. L., Spychalla, A. J., Knopman, D. S., et al. (2020) · Brain · doi:10.1093/brain/awaa299 · Cited by 76
“studies of Alzheimer’s disease have found smaller hippocampal volumes to be associated with amyloid-b (Zarow et al., 2005) and tau deposition (Jack et al.”
Background
Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly
Glodzik, L., Rusinek, H., Pirraglia, E., McHugh, P. F., Tsui, W., Williams, S., Cummings, M., Li, Y., Rich, K. E., Randall, C., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.011 · Cited by 78
“It is also particularly sensitive to hypoperfusion (Zarow et al., 2005; ZolaMorgan et al., 1992).”
Background
Volumetry of the human amygdala — An anatomical study
Brabec, J., Rulseh, A. M., Hoyt, B. S., Vízek, M., Hořínek, D., Hort, J., & Petrovický, P. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.11.005 · Cited by 77
“The correlation of regional atrophy and neuronal loss provides a rationale forMRI volumetric studies (Zarow et al., 2005; Horinek et al., 2007).”
Mild Cognitive Impairment after Lacunar Infarction: Voxel-Based Morphometry and Neuropsychological Assessment
Grau-Olivares, M., David Bartrés-faz, A., Arboix, A., Soliva, J.-C., Rovira, M., Targa, C., & Junqué, C. (2007) · Cerebrovascular Diseases · doi:10.1159/000099134 · Cited by 77
“whereas other results indicate that the number of neurons is significantly reduced in Alzheimer’s disease as compared to ischemic vascular disease patients but that it correlates with MRI volumes of the structure [”
Result
Comparing 3T and 1.5T MRI for Mapping Hippocampal Atrophy in the Alzheimer's Disease Neuroimaging Initiative
Chow, N., Hwang, K. S., Hurtz, S., Green, A. E., Somme, J. H., Thompson, P. M., Elashoff, D. A., Jack, C. R., Weiner, M. W., & Apostolova, L. G. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4228 · Cited by 76
Self-citation
Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia
Frölich, L., Peters, O., Lewczuk, P., Gruber, O., Teipel, S. J., Gertz, H., Jahn, H., Jessen, F., Kurz, A., Luckhaus, C., et al. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0301-7 · Cited by 82
“Neuronal and synaptic losses are key determinants of cognitive impairment, which are accompanied by brain atrophy on magnetic resonance imaging (MRI) [3, 4].”
Background
Insights into the neuropathology of cerebral ischemia and its mechanisms
Ahad, M. A., Kumaran, K. R., Tiang, N., Mansor, N. I., Effendy, M. A., Damodaran, T. K., Lingam, K., Wahab, H. A., Nordin, N., Liao, P. H., et al. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0099 · Cited by 77
Proton MRS in mild cognitive impairment
Kantarci, K. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23800 · Cited by 76
Region-Specific Genetic Alterations in the Aging Hippocampus: Implications For Cognitive Aging
Bürger, C. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00140 · Cited by 75
“These reports suggest that the CA1 region is more susceptible to amyloid plaque deposits and ischemia relative to CA3(Gozal et al., 2002; West et al., 2004; Zarow et al., 2005; Wu et al., 2008).”
Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease
Blanco, K., Salcidua, S., Orellana, P., Sauma-Pérez, T., León, T., Steinmetz, L. C. L., Ibañez, A., Duran-Aniotz, C., & de la Cruz, R. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01304-8 · Cited by 73
Framingham Cardiovascular Risk Profile Correlates with Impaired Hippocampal and Cortical Vasoreactivity to Hypercapnia
Glodzik, L., Rusinek, H., Bryś, M., Tsui, W. H., Switalski, R., Mosconi, L., Mistur, R. L., Pirraglia, E., Santi, S. D., Li, Y., et al. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.145 · Cited by 73
“As hippocampal cornu ammonis sector1 is highly sensitive to both AD pathology and ischemia (Zarow et al, 2005), the presence of vascular risk can strongly compound on AD-related damage.”
Background
Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study
Yu, J., Li, J., Suckling, J., Feng, L., Pan, A., Wang, Y., Song, B., Zhu, S., Li, D., Wang, H.-F., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.05.006 · Cited by 72
“In fact, the two methods for defining N track distinct aspects of the AD pathophysiological process: Atrophy on MRI reflects dendritic and neuronal losses, and FDG PET likely indicates synaptic activity and loss of synapses [21,22].”
Self-citation
Radiological-Pathological Correlation in Alzheimer’s Disease: Systematic Review of Antemortem Magnetic Resonance Imaging Findings
Dallaire‐Théroux, C., Callahan, B. L., Potvin, O., Saïkali, S., & Duchesne, S. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161028 · Cited by 71
“In contrast, the two other groups found no signiﬁcant association between whole-brain, ventricular and hippocampal volumes and ischemic, hemorrhagic or vascular pathology [52, 57].”
Influential
Is apolipoprotein E4 an important risk factor for vascular dementia?
Rohn, T. T. (2014) · PubMed Central · Cited by 68
Biomarkers in translational research of Alzheimer’s Disease
Tarawneh, R., & Holtzman, D. M. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.04.006 · Cited by 67
“Evidence from neuropathological studies of AD indicate that atrophy on structural magnetic resonance imaging (MRI) is a good surrogate of NFT formation and can capture the cumulative outcome of the neurodegenerative process; neuronal and synaptic loss, and loss of supporting cellular structures (Bobinski et al., 2000;…”
Background
Hippocampal subfield volumetry in patients with subcortical vascular mild cognitive impairment
Li, X., Li, D., Li, Q., Li, Y., Li, K., Li, S., & Han, Y. (2016) · Scientific Reports · doi:10.1038/srep20873 · Cited by 70
Toward an interpretable Alzheimer’s disease diagnostic model with regional abnormality representation via deep learning
Lee, E., Choi, J.-S., Kim, M., & Suk, H.-I. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116113 · Cited by 61
“In AD, cortical neuronal loss leaves disease-related pathological patterns that can be captured by structural MRI (sMRI) (Zarow et al., 2005).”
Background
Alliance for aging research AD biomarkers work group: structural MRI
Jack, C. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.011 · Cited by 64
“Excellent correlation is found between hippocampal volume measures obtained on either antemortem MRI (Zarow et al., 2005) or postmortem MRI (Bobinski et al., 2000) and hippocampal neuron cell counts in autopsy specimens.”
Hippocampal Atrophy in Subcortical Vascular Dementia
van de Pol, L. A., Gertz, H., Scheltens, P., & Wolf, H. (2011) · Neurodegenerative Diseases · doi:10.1159/000326695 · Cited by 63
“However, none of these studies strictly focused on SVaD. The mechanisms of Hc atrophy in SVaD remain unclear and could be heterogeneous. One possible explanation for our findings is that cooccurrent Alzheimer pathology, particularly neurofibrillary tangles (NFT), may have contributed to the Hc atrophy seen in SVaD. Cl…”
Background
GABA‐containing compound gammapyrone protects against brain impairments in Alzheimer’s disease model male rats and prevents mitochondrial dysfunction in cell culture
Piļipenko, V., Narbute, K., Amara, I., Salinaro, A. T., Scuto, M. C., Pupure, J., Jansone, B., Poikāns, J., Bisenieks, E., Kluša, V., et al. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24396 · Cited by 58
“The lat‐ ter structure was chosen because more pronounced loss of CA1 neurons occurs in AD, correlating with memory impairment (West, Kawas, Martin, & Troncoso, 2006; Zarow et al., 2005).”
Method
Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI
Blanken, A. E., Hurtz, S., Zarow, C., Biado, K., Honarpisheh, H., Somme, J. H., Brook, J. K., Tung, S., Kraft, E., Lo, D. C. W., et al. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.04.020 · Cited by 57
“lobes were sectioned coronally into 5 mm slabs, embedded in paraffin from which 6 sections were cut (Zarow et al., 2005).”
Self-citation

Authors: Zarow, C., Vinters, H. V., Ellis, W. G., Weiner, M. W., Mungas, D., White, L., & Chui, H. C.
Affiliations: University of Southern California (US)
University of California, Los Angeles (US)
University of California Davis Medical Center (US)
University of California, San Francisco (US)
University of California, Davis (US)
Kuakini Medical Center (US)
Corresponding author: Zarow, Chris
ORCID: Vinters, Harry V.
Weiner, Michael W.
Mungas, Dan
White, Lon
Chui, Helena C.
Venue: Annals of Neurology
Publisher: Wiley
Published: 2005-05-31
Volume: 57
Issue: 6
Pages: 896-903
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.20503
PMC: PMC1851673
OpenAlex: W2106775021
Cited by: 241
References: 26
Citations by year: 2026: 3 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 11 · 2020: 23 · 2019: 10 · 2018: 10 · 2017: 16 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 19 · 2012: 8
FWCI: 7.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P50AG016570, P50-AG 16570, 1P01 AG12435, R01AG017155, R01AG010897, 1-R01-AG17155, P01AG012435)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, cornu ammonis 1, neuronal loss, neuron size, hippocampal volume, hippocampal sclerosis, neurofibrillary degeneration, stereology
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Brain Ischemia, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Neurons, Neuropsychological Tests, Prospective Studies, Dementia, Vascular, Lewy Bodies

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Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia

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