The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Clinical and pathological characterization of progressive aphasia
Open accessAbstract
Objective: The clinical and neuropathological categorization of patients presenting with progressive aphasia is an area of controversy. This study aimed to characterize a large group of progressive aphasic patients from a single center (n = 38), first clinically by case note review, and then pathologically. Methods: Hierarchical cluster analysis of the cases according to their clinical language deficits was used to establish an unbiased, data‐driven classification. Results: This analysis revealed two groups of cases corresponding to the syndromes of progressive nonfluent aphasia (n = 23) and semantic dementia (n = 15). Postmortem analysis showed a majority in both groups of pathologies from the spectrum of frontotemporal lobar degeneration: the most frequent were non–Alzheimer's disease (AD) tauopathy in the nonfluent cases (10 of 23) and frontotemporal lobar degeneration with ubiquitin‐positive, tau‐negative inclusions in the fluent cases (8 of 15). Despite rigorous exclusion of cases with clinically significant memory deficits or other cognitive impairments, the pathology of AD was present in approximately one third of each group (overall 12 of 38), although often with an atypical neuroanatomical distribution. Interpretation: Progressive aphasia is best seen as a composite of two conditions, on both clinical and pathological levels: progressive nonfluent aphasia and semantic dementia. Ann Neurol 2006;59:156–165
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Cites
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Clinicopathological correlates in frontotemporal dementia
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Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer’s disease
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“6) 11 (73) 9 (39) Impaired sentence comprehension 19 (50.”
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Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141
Self-citationAutomatic classification of MR scans in Alzheimer’s disease.
Kloppel, S., Stonnington, C. M., Chu, C., Draganski, B., Scahill, R. I., Rohrer, J. D., Fox, N. C., Jack, C. R., Ashburner, J., & Frackowiak, R. S. J. (2008) · Brain · doi:10.1093/brain/awm319 · Cited by 1,170
Semantic dementia: a unique clinicopathological syndrome
Hodges, J. R., & Patterson, K. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70266-1 · Cited by 772
Self-citationThe logopenic/phonological variant of primary progressive aphasia
Gorno-Tempini, M. L., Brambati, S. M., Ginex, V., Ogar, J., Dronkers, N. F., Marcone, A., Perani, D., Garibotto, V., Cappa, S. F., & Miller, B. L. (2008) · Neurology · doi:10.1212/01.wnl.0000320506.79811.da · Cited by 710
FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
Foster, N. L., Heidebrink, J. L., Clark, C. M., Jagust, W. J., Arnold, S. E., Barbas, N. R., DeCarli, C. S., Scott Turner, R., Koeppe, R. A., Higdon, R., et al. (2007) · Brain · doi:10.1093/brain/awm177 · Cited by 608
Metadata
- Authors
- Knibb, J. A., Xuereb, J. H., Patterson, K., & Hodges, J. R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2005-12-22
- Volume
- 59
- Issue
- 1
- Pages
- 156-165
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2094206043
- Cited by
- 342
- References
- 5
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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