Cited by 479Multiple Sclerosis Research StudiesAnimal testing and alternativesPeripheral Neuropathies and Disorders

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How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis.

Steinman, Lawrence, Zamvil, Scott S.·2006·Annals of Neurology

DOI 10.1002/ana.20913

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Abstract

In their Point of View entitled "Experimental Allergic Encephalomyelitis: A Misleading Model of Multiple Sclerosis," Sriram and Steiner(1) wrote, "The most disappointing aspect of EAE [experimental allergic encephalomyelitis] as a potential model for MS is its almost total inability to point toward a meaningful therapy or therapeutic approach for MS." Actually, EAE has led directly to the development of three therapies approved for use in multiple sclerosis (MS): glatiramer acetate, mitoxantrone, and natalizumab. Several new approaches to MS are in clinical trials based on positive indications in preclinical work relying on EAE. New clues to the pathogenesis of MS and new potential surrogate markers for MS are shown from research involving EAE when it is critically coupled with actual findings in MS. There are pitfalls in overreliance on the EAE model, or on any animal model for any human disease. Nevertheless, over the past 73 years, the EAE model has proved itself remarkably useful for aiding research on MS.

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Authors: Steinman, L., & Zamvil, S. S.
Affiliations: Stanford University (US)
University of California, San Francisco (US)
Corresponding author: Steinman, Lawrence
ORCID: Steinman, Lawrence
Zamvil, Scott S.
Venue: Annals of Neurology
Publisher: Wiley
Published: 2006-06-26
Volume: 60
Issue: 1
Pages: 12-21
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.20913
OpenAlex: W2140830894
Cited by: 479
References: 88
Citations by year: 2026: 5 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 23 · 2021: 18 · 2020: 17 · 2019: 17 · 2018: 13 · 2017: 19 · 2016: 22 · 2015: 23 · 2014: 29 · 2013: 44 · 2012: 37
FWCI: 5.49
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: Multiple Sclerosis Society
National Institute of Allergy and Infectious Diseases (R01AI059709)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords: experimental autoimmune encephalomyelitis, multiple sclerosis, animal models of disease, translational research, glatiramer acetate, mitoxantrone, natalizumab, MS pathogenesis, surrogate markers, preclinical drug development
MeSH terms: Animals, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Humans, Multiple Sclerosis

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How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis.

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