The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Paraneoplastic anti– N ‐methyl‐ D ‐aspartate receptor encephalitis associated with ovarian teratoma
Open accessAbstract
OBJECTIVE: To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis. METHODS: Analysis of clinical features, neuropathological findings, tumors, and serum/cerebrospinal fluid antibodies using rat tissue, neuronal cultures, and HEK293 cells expressing subunits of the N-methyl-D-aspartate receptor (NMDAR). RESULTS: Twelve women (14-44 years) developed prominent psychiatric symptoms, amnesia, seizures, frequent dyskinesias, autonomic dysfunction, and decreased level of consciousness often requiring ventilatory support. All had serum/cerebrospinal fluid antibodies that predominantly immunolabeled the neuropil of hippocampus/forebrain, in particular the cell surface of hippocampal neurons, and reacted with NR2B (and to a lesser extent NR2A) subunits of the NMDAR. NR2B binds glutamate and forms heteromers (NR1/NR2B or NR1/NR2A/NR2B) that are preferentially expressed in the adult hippocampus/forebrain. Expression of functional heteromers (not single subunits) was required for antibody binding. Eleven patients had teratoma of the ovary (six mature) and one a mature teratoma in the mediastinum; five of five tumors examined contained nervous tissue that strongly expressed NR2 subunits and reacted with patients' antibodies. Tumor resection and immunotherapy resulted in improvement or full recovery of eight of nine patients (paralleled by decreased antibody titers); two of three patients without tumor resection died of neurological deterioration. Autopsies showed extensive microgliosis, rare T-cell infiltrates, and neuronal degeneration predominantly involving, but not restricted to, the hippocampus. INTERPRETATION: Antibodies to NR2B- and NR2A-containing heteromers of the NMDAR associate with a severe but treatment-responsive encephalitis. Our findings provide a diagnostic test and suggest a model of autoimmune NMDAR-related encephalitis with broad implications for other immune-mediated disorders of memory, behavior, and cognition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Preliminary studies suggested the target epitopes were located in extracellular regions of NR1–NR2B NMDA receptors.5”
From Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies (2008) · cites this paper as [5]
In the citing paper
“We recently identified a disorder, designated anti-NMDA-receptor encephalitis, that associates with antibodies against NR1–NR2 heteromers and results in a characteristic neuropsychiatric syndrome.5”
From Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies (2008) · cites this paper as [5]
In the citing paper
“The first patients identified were young women with ovarian teratoma who presented with psychosis or memory problems, rapidly progressing to multiple neurological deficits requiring prolonged intensive care support.”
From Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies (2008) · cites this paper as [5]
In the citing paper
“Serum and CSF were tested for antibodies against the NMDA receptor,5 and considered positive if three immunohistochemical criteria were fulfilled (figure 1).”
From Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies (2008) · cites this paper as [5]
In the citing paper
“Despite the severity of the disorder, patients often recovered after tumour removal and immunotherapy, suggesting an immune-mediated pathogenesis.”
From Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies (2008) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535
Gultekin, S. H. (2000) · Brain · doi:10.1093/brain/123.7.1481 · Cited by 1,110
Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients
Graus, F. (2001) · Brain · doi:10.1093/brain/124.6.1138 · Cited by 891
DeGiorgio, L. A., Konstantinov, K. N., Lee, S. C., Hardin, J., Volpe, B. T., & Diamond, B. (2001) · Nature Medicine · doi:10.1038/nm1101-1189 · Cited by 798
Clinical analysis of anti-Ma2-associated encephalitis
Dalmau, J. O. (2004) · Brain · doi:10.1093/brain/awh203 · Cited by 776
Antigen unmasking on formalin‐fixed, paraffin‐embedded tissue sections
Cattoretti, G., Pileri, S. A., Parravicini, C., Becker, M. H. G., Poggi, S., Bifulco, C. B., Key, G., D'Amato, L., Sabattini, E., Feudale, E. A. A., et al. (1993) · The Journal of Pathology · doi:10.1002/path.1711710205 · Cited by 721
Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma
Vitaliani, R., Mason, W. P., Ances, B. M., Zwerdling, T., Jiang, Z., & Dalmau, J. O. (2005) · Annals of Neurology · doi:10.1002/ana.20614 · Cited by 604
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates
Ances, B. M., Vitaliani, R., Taylor, R. A., Liebeskind, D. S., Voloschin, A. D., Houghton, D. J., Galetta, S. L., Dichter, M. A., Alavi, A. A., Rosenfeld, M. R., et al. (2005) · Brain · doi:10.1093/brain/awh526 · Cited by 486
Laube, B., Hirai, H., Sturgess, M., Betz, H., & Kuhse, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)81249-0 · Cited by 476
Wenzel, A., Fritschy, J., Möhler, H., & Benke, D. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68020469.x · Cited by 442
Cited by
Sorted by citations
Items 801–900 of 1,000
Wang, X., Ma, C., Liu, C., Li, G., Zhao, D., & Han, D. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00684 · Cited by 20
Kelleher, E., Barry, H., Cotter, D., Corvin, A. P., & Murphy, K. C. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_90 · Cited by 20
Brain astrocytoma misdiagnosed as anti-NMDAR encephalitis: a case report
Lu, J., Zhang, J., Miao, A., Yin, J., Zhu, D., Lin, X., Chen, D.-W., & Shi, J. (2019) · BMC Neurology · doi:10.1186/s12883-019-1436-x · Cited by 20
Simon, D. W., Silva, Y. S. D., Zuccoli, G., & Clark, R. S. B. (2013) · Critical Care Clinics · doi:10.1016/j.ccc.2013.01.001 · Cited by 20
Glutamatergic autoencephalitides: an emerging field
Panzer, J. A., Gleichman, A. J., & Lynch, D. R. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-013-1152-4 · Cited by 21
Analysis of antibodies to neuronal surface antigens in adult opsoclonus–myoclonus
Sabater, L., Xifró, X., Saiz, A., Alberch, J., & Graus, F. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.03.013 · Cited by 20
Shimazaki, H., Morita, M., Nakano, I., & Dalmau, J. O. (2008) · Archives of Neurology · doi:10.1001/archneur.65.9.1251 · Cited by 20
Anti-N-Methyl-d-Aspartate Receptor Encephalitis in a Young Woman with a Mature Mediastinal Teratoma
Stover, D. G., Eisenberg, R., & Johnson, D. H. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181eba81d · Cited by 20
Takahashi, Y. (2008) · Annals of Neurology · doi:10.1002/ana.21362 · Cited by 20
Pathophysiological Effects of Autoantibodies in Autoimmune Encephalitides
Ryding, M., Mikkelsen, A. W., Nissen, M. S., Nilsson, A. C., & Blaabjerg, M. (2023) · Cells · doi:10.3390/cells13010015 · Cited by 20
Antibodies in neurological diseases: Established, emerging, explorative
Li, L. Y., Keles, A., Homeyer, M. A., & Prüß, H. (2024) · Immunological Reviews · doi:10.1111/imr.13405 · Cited by 22
Update Anti-N-Methyl-D-Aspartat-Rezeptor-Enzephalitis
Kovac, S., Alferink, J., Ahmetspahic, D., Arolt, V., & Melzer, N. (2017) · Der Nervenarzt · doi:10.1007/s00115-017-0405-0 · Cited by 19
Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Feng, J., Fan, S., Sun, Y., Zhang, Z., Ren, H., Li, W., Cui, L., Peng, B., Ren, X., Zhang, W., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01539 · Cited by 19
Appu, M., & Noetzel, M. J. (2013) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2013.11.001 · Cited by 19
Anti-N-methyl-D-Aspartate-Receptor Encephalitis in a Four-Year-Old Girl
Biancheri, R., Pessagno, A., Baglietto, M. G., Irani, S. R., Rossi, A., Giribaldi, G., Mirabelli-Badenier, M., Vincent, A. C., & Veneselli, E. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.07.057 · Cited by 19
Anti-N-Methyl-d-aspartate-receptor encephalitis: Cognitive profile in two children
Iadisernia, E., Battaglia, F. M., Vanadia, E., Trapolino, E., Vincent, A. C., & Biancheri, R. (2011) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2011.09.004 · Cited by 19
Ryan, N. R. (2015) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2015.11.005 · Cited by 19
Kramina, S., Kevere, L., Bezborodovs, N., Purvina, S., Rozentals, G., Strautmanis, J., & Vīksna, Z. (2015) · PsyCh Journal · doi:10.1002/pchj.121 · Cited by 19
Cerebrospinal fluid pentraxin 3 and CD40 ligand in anti-N-menthyl-d-aspartate receptor encephalitis
Liu, B., Ai, P., Zheng, D., Jiang, Y., Liu, X., Pan, S., & Wang, H. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.11.016 · Cited by 19
Gastaldi, M., Nosadini, M., Spatola, M., Sartori, S., & Franciotta, D. M. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1431124 · Cited by 19
Ferensztajn‐Rochowiak, E., Kaczmarek, M., Wójcicka, M., Kaufman-Szukalska, E., Dziuda, S., Remlinger-Molenda, A., Szeliga-Neymann, A., Losy, J., & RYBAKOWSKI, J. K. (2018) · Neuropsychobiology · doi:10.1159/000493740 · Cited by 19
Howarth, R. A., Vova, J. A., & Blackwell, L. S. (2018) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000001087 · Cited by 19
Wang, Y., Miao, A., Shi, Y., Ge, J., Wang, L., Yu, C., Xu, H., Yu, Y., Huang, S., Li, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67485-6 · Cited by 19
Howard, C. M., Kass, J. S., Bandi, V., & Guntupalli, K. K. (2014) · CHEST Journal · doi:10.1378/chest.13-1490 · Cited by 19
The Evolution of Neurocritical Care
Korbakis, G., & Bleck, T. P. (2014) · Critical Care Clinics · doi:10.1016/j.ccc.2014.06.001 · Cited by 19
Clinical Reasoning: Agitation and psychosis in a patient after renal transplantation
Zhao, C. Z., Erickson, J. C., & Dalmau, J. O. (2012) · Neurology · doi:10.1212/wnl.0b013e3182616fad · Cited by 19
Les syndromes neurologiques paranéoplasiques
Didelot, A., & Honnorat, J. (2010) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2010.09.007 · Cited by 19
Tsutsui, K., Kanbayashi, T., Takaki, M., Omori, Y., Imai, Y., Nishino, S., Tanaka, K., & Shimizu, T. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s125800 · Cited by 19
Guo, K., Peng, F., Liu, J., Long, Y., Guo, S., Wang, H., Yu, G., Zhang, Y., Han, X., Tu, E., et al. (2025) · Annals of Neurology · doi:10.1002/ana.27218 · Cited by 18
Emerging role of prodromal headache in patients with anti-N-methyl-D-aspartate receptor encephalitis
Ma, C., Wang, C., Zhang, Q., & Lian, Y. (2019) · Journal of Pain Research · doi:10.2147/jpr.s189301 · Cited by 18
Catatonia associated with epileptic seizures: A systematic review of case reports
Gadelho, L. S., & Marques, J. G. (2022) · Epilepsy Research · doi:10.1016/j.eplepsyres.2022.107016 · Cited by 18
Çalbıyık, M., & Zehir, S. (2023) · Medicine · doi:10.1097/md.0000000000034208 · Cited by 18
Huang, T., Liu, F., Wang, B., Wang, C., Hao, M., & Guo, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1213532 · Cited by 18
Liu, X., Zheng, X., Shu, Y., Qu, X., Wang, Q., Liu, X., Hu, F., Liu, J., Lian, Y., He, B.-M., et al. (2024) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200221 · Cited by 18
Guan, W., Fu, Z., Zhang, H., Jing, L., Lu, J., Zhang, J., Lu, H., Teng, J., & Jia, Y. (2015) · Journal of Child Neurology · doi:10.1177/0883073815575365 · Cited by 18
Liu, H., Jian, M., Liang, F., Yue, H., & Han, R. (2015) · BMC Anesthesiology · doi:10.1186/s12871-015-0134-5 · Cited by 18
Reactions of the immune system in epilepsy.
Cojocaru, I. M., & Cojocaru, M. (2010) · Europe PMC (PubMed Central) · Cited by 18
Paraneoplastic neurological disorders in children with benign ovarian tumors
Hsu, M., Huang, C., Hung, P., Huang, H.-M., Huang, L., Huang, C.-C., Sheen, J., Huang, S., & Chang, Y. (2013) · Brain and Development · doi:10.1016/j.braindev.2013.04.009 · Cited by 18
Correll, C. M. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0348-1 · Cited by 18
Pascual-Ramírez, J., Muñoz-Torrero, J. J., Bacci, L., Trujillo, S. G., & García-Serrano, N. (2011) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2011.07.028 · Cited by 18
Shaaban, H. S., Choo, H., & Sensakovic, J. W. (2012) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2012.421 · Cited by 18
Ultrasound‐guided laparoscopic ovarian preserving surgery to treat anti‐ NMDA receptor encephalitis
Jones, B. P., Rees, R. N., Saso, S., Stalder, C. M., Smith, J., & Yazbek, J. (2016) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14214 · Cited by 18
Yu, P., Liu, X., Pan, S., Xie, Z., & Wang, H. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2718-3 · Cited by 18
Chen, Y., Wang, C., Xu, F., Ming, F., & Zhang, H. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.07.009 · Cited by 18
Molina, R. D., Conzatti, L. P., da Silva, A. P. B., Goi, L. D. S., da Costa, B. K., Machado, D. C., & Sato, D. K. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101858 · Cited by 19
Luo, Y., Li, J., Jiang, F., Tan, A., Qin, X., Xiao, X., Wang, Z., Wang, P., Yang, Y., Li, J., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.827138 · Cited by 18
Boangher, S., Mespouille, P., Filip, C.-M., & Goffette, S. (2016) · Case Reports in Neurological Medicine · doi:10.1155/2016/3263718 · Cited by 18
Konen, F. F., Schwenkenbecher, P., Jendretzky, K. F., Hümmert, M. W., Wegner, F., Stangel, M., Sühs, K., & Skripuletz, T. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00987 · Cited by 18
Komagamine, T., Kokubun, N., & Hirata, K. (2019) · History of Psychiatry · doi:10.1177/0957154x19877145 · Cited by 17
Chen, W., Li, Q., Wang, T., Fan, L., Gao, L., Huang, Z., Lin, Y., Qin, X., Liu, G., Su, Y., et al. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103020 · Cited by 17
Du, B., Lai, Q., Li, E., Cai, M., Fang, G., Shen, C., Zhang, Y., & Ding, M. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad109 · Cited by 17
Converging synaptic and network dysfunctions in distinct autoimmune encephalitis
Hunter, D., Petit‐Pedrol, M., Fernandes, D., Bénac, N., Rodrigues, C., Kreye, J., Ceangă, M., Prüß, H., Geis, C., & Groc, L. (2024) · EMBO Reports · doi:10.1038/s44319-024-00056-2 · Cited by 17
Wang, R., Chen, B.-D., & Qi, D. (2015) · BMC Neurology · doi:10.1186/s12883-015-0366-5 · Cited by 17
Limbic Encephalitis and Variants Related to Neuronal Cell Membrane Autoantigens
Dalmau, J. O. (2008) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.48.871 · Cited by 17
Dazed, Confused, and Asystolic: Possible Signs of Anti–N-Methyl-D-Aspartate Receptor Encephalitis
Ziaeian, B., & Shamsa, K. (2015) · Texas Heart Institute Journal · doi:10.14503/thij-13-3987 · Cited by 17
Anti-NMDA receptor encephalitis presenting as atypical anorexia nervosa: an adolescent case report
Mechelhoff, D., van Noort, B. M., Weschke, B., Bachmann, C., Wagner, C., Pfeiffer, E. F., & Winter, S. (2015) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-015-0682-8 · Cited by 17
First-onset psychosis, anti-NMDAR encephalitis, schizophrenia and Consultation–Liaison psychiatry
van de Riet, E. H. C. W., & Schieveld, J. N. M. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.01.014 · Cited by 17
Rheumatic Manifestations of Cancer
Ashouri, J. F., & Daikh, D. (2011) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2011.09.001 · Cited by 17
Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient with Systemic Lupus Erythematosus
Wu, Y.-Y., Yan, F., Huang, Y. M., & Zhang, J.-W. (2016) · Journal of Clinical Neurology · doi:10.3988/jcn.2016.12.4.502 · Cited by 17
Ethical Implications of the Mild Encephalitis Hypothesis of Schizophrenia
Riedmüller, R., & Müller, S. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00038 · Cited by 17
Critical updates in the 7th edition of the American Society for Apheresis guidelines
Ipe, T. S., Pham, H. P., & Williams, L. A. (2017) · Journal of Clinical Apheresis · doi:10.1002/jca.21562 · Cited by 17
Shin, J.-W., Koo, Y. S., Kim, Y., Kim, D. W., Kim, K. K., Lee, S., Kim, H. K., Moon, H., Lim, J., Byun, J., et al. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.12.004 · Cited by 17
Anti–NMDAR encephalitis complicating pregnancy
Kalam, S., Baheerathan, A., McNamara, C., & Singh‐Curry, V. (2018) · Practical Neurology · doi:10.1136/practneurol-2018-002042 · Cited by 17
Anti-NMDA Receptor Encephalitis, Vaccination and Virus
Wang, H. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191210155059 · Cited by 17
Receptor autoimmunity: diagnostic and therapeutic implications
Tozzoli, R. (2020) · Autoimmunity Highlights · doi:10.1186/s13317-019-0125-5 · Cited by 17
Encephalitis in Previously Healthy Children
Fraley, C. E., Pettersson, D. R., & Nolt, D. L. (2021) · Pediatrics in Review · doi:10.1542/pir.2018-0175 · Cited by 17
Aberrant multimodal brain networks in patients with anti‐NMDA receptor encephalitis
Wang, J., Duan, Y., Zhang, T., Huang, J., Ren, Z., Ye, J., Wang, N., Li, Y., Chen, X., Gao, P., et al. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13632 · Cited by 18
N-Methyl- -Aspartate receptor and inflammation in dorsolateral prefrontal cortex in schizophrenia
Rahman, T., Purves-Tyson, T. D., Geddes, A. E., Huang, X., Newell, K. A., & Weickert, C. S. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.11.045 · Cited by 18
Anti-NMDA Encephalitis: An Uncommon, Autoimmune Mediated Form of Encephalitis
Azizyan, A., Albrektson, J. R., Maya, M. M., Pressman, B. D., & Moser, F. G. (2014) · Journal of Radiology Case Reports · doi:10.3941/jrcr.v8i8.1566 · Cited by 17
Sawamura, H., Yamamoto, T., Ohtomo, R., Bannai, T., Wakakura, M., & Tsuji, S. (2014) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000117 · Cited by 17
Anti-N-methyl-D-aspartate receptor encephalitis complicating ovarian teratomas: a case report
Naoura, I., Didelot, A., Walker, F., Luton, D., & Koskas, M. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.05.008 · Cited by 17
Rituximab for Treatment of Refractory Anti-NMDA Receptor Encephalitis in a Pediatric Patient
Hallowell, S. A., Tebedge, E., Oates, M., & Hand, E. (2017) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-22.2.118 · Cited by 17
Paraneoplastic neurological syndromes
Iorio, R., Spagni, G., & Masi, G. (2019) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2019.06.005 · Cited by 20
Davydovskaya, M. V., Boyko, A. N., Beliaeva, I. A., Martynov, M. Y., & Gusev, E. Y. (2015) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20151154195-101 · Cited by 17
de Nayer, A. R., Myant, N., & Sindic, C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.031 · Cited by 17
Zhao-Fleming, H. H., Rezk, M. S. M., Shah, S., Gupta, P., Ζεκερίδου, Α., Flanagan, E. P., Pittock, S. J., McKeon, A. B., & Dubey, D. (2024) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200316 · Cited by 16
Liu, J., Li, M., Liu, J., Zheng, D., Zhou, Y., Li, Y., Chen, X., Lin, Y., Yang, L., Xiaofeng, X., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123597 · Cited by 16
Wong, K., Day, G. S., Torner, J. C., Cudkowicz, M., Coffey, C. S., Cho, H. J., Utz, U., Clifford, D. B., Katz, E., Ratchford, J. N., et al. (2025) · Neurology Open Access · doi:10.1212/wn9.0000000000000007 · Cited by 16
Anti-NMDA Receptor Encephalitis: A Narrative Review
Pădureanu, V., Dop, D., Pădureanu, R., Pîrșcoveanu, D. F. V., Olaru, G., Streață, I., & Bugă, A. M. (2025) · Brain Sciences · doi:10.3390/brainsci15050518 · Cited by 16
Mei, Y., Yang, J., Yuan, Y., Liu, Y., Liu, X., Li, M. L., Fan, S., Li, L., Jiang, C., & Xu, Y. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.709553 · Cited by 16
Eaton, J. E., Kleinholz-Owens, P., Sriram, S., & Pawate, S. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.120042 · Cited by 16
Blackman, G., Lim, M. F., Pollak, T. A., Al‐Diwani, A., Symmonds, M., Mazumder, A., Carter, B., Irani, S. R., & David, A. S. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11224-6 · Cited by 16
Anti-amphiphysin encephalitis: Expanding the clinical spectrum
Sun, Y., Qin, X., Huang, D., Zhou, Z., Zhang, Y., & Wang, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1084883 · Cited by 16
Clinical features and brain MRI volumetric changes in anti‐mGluR5 encephalitis
Sun, Y., Tao, J. X., Han, X., Wang, X., Zhu, Y., Lian, Y., Ren, G., & Wang, Q. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51831 · Cited by 17
The Neuropsychiatric Checklist for Autoimmune Psychosis: A Narrative Review
van Elst, L. T., Runge, K., Meyer, P. T., Urbach, H., Venhoff, N., & Prüß, H. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.02.889 · Cited by 18
Melzer, N., Budde, T., Stork, O., & Meuth, S. G. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00171 · Cited by 16
Kanazawa, K., Matsumoto, R., Shimotake, A., Kinoshita, M., Otsuka, A., Watanabe, O., Tanaka, K., Takahashi, R., & Ikeda, A. (2014) · Epileptic Disorders · doi:10.1684/epd.2014.0664 · Cited by 16
Limbic Encephalitis and Related Cortical Syndromes
Rubio‐Agusti, I., Salavert, M., & Bataller, L. (2012) · Current Treatment Options in Neurology · doi:10.1007/s11940-012-0212-7 · Cited by 16
Autoimmune encephalitis: Clinical diagnosis versus antibody confirmation
Thomas, S., Cyril, A., Nair, S., Mathai, A., & Kannoth, S. (2015) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.165454 · Cited by 16
Amorim, E., & McDade, E. (2016) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2016.01.028 · Cited by 16
Treatment principles of ovarian teratoma with anti-N-methyl-d-aspartate receptor encephalitis
Bai, Y., Qiyun, G., Jiang, J., & Zhang, Z. (2016) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-016-4050-9 · Cited by 16
Anti-NMDAR encephalitis and other glutamate and GABA receptor antibody encephalopathies
de Bruijn, M. A. A. M., & Titulaer, M. J. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63432-0.00012-8 · Cited by 16
Shimoyama, Y., Umegaki, O., Agui, T., Kadono, N., & Minami, T. (2016) · JA Clinical Reports · doi:10.1186/s40981-016-0048-3 · Cited by 16
Suicidality is a common and serious feature of anti-N-methyl-D-aspartate receptor encephalitis
Zhang, L., Sander, J. W. A. S., Zhang, L., Jiang, X., Wang, W., Shuang, K., Abdulaziz, A. T. A., Wu, M., Chi, X., Li, J., et al. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8626-5 · Cited by 15
Immune-mediated encephalitis for the infectious disease specialist
Venkatesan, A. (2019) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000546 · Cited by 16
Lennox, B., Yeeles, K., Jones, P. B., Zandi, M. S., Joyce, E. M., Yu, L., Tomei, G., Pollard, R., Vincent, S.-A., Shimazaki, M., et al. (2019) · Trials · doi:10.1186/s13063-019-3336-1 · Cited by 16
Elevated CHI3L1 and OPN levels in patients with anti-N-methyl-d-aspartate receptor encephalitis
Zhao, J., Wang, C., Zhang, Y., Sun, R., Wang, H., Li, G., & Zhang, J. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.577005 · Cited by 16
Neurodevelopmental outcomes in paediatric immune-mediated and autoimmune epileptic encephalopathy
Wright, S. K., & WOOD, A. G. (2019) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2019.12.010 · Cited by 16
Restrepo-Martínez, M., Ramírez‐Bermúdez, J., Bayliss, L., & Espínola-Nadurille, M. (2020) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2020.03.003 · Cited by 16
Associations between seizures and MRI in patients with anti‐NMDAR encephalitis
Ni, G., Lin, W., Cai, X., Qin, J., Feng, L., Zhu, S., Zhou, L., & Chen, Z. (2020) · Acta Neurologica Scandinavica · doi:10.1111/ane.13298 · Cited by 16
Metadata
- Authors
- Dalmau, J., Tüzün, E., Wu, H., Masjuan, J., Rossi, J. E., Voloschin, A., Baehring, J. M., Shimazaki, H., Koide, R., King, D., Mason, W., Sansing, L. H., Dichter, M. A., Rosenfeld, M. R., & Lynch, D. R.
- Affiliations
- University of Pennsylvania (US)
- Augusta University (US)
- Yale University (US)
- Jichi Medical University (JP)
- Tokyo Metropolitan Neurological Hospital (JP)
- Children's Hospital of Pittsburgh (US)
- Princess Margaret Cancer Centre (CA)
- Corresponding author
- Dalmau, Josep
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 61
- Issue
- 1
- Pages
- 25-36
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC2430743
- OpenAlex
- W2114398221
- Cited by
- 2,492
- References
- 37
- Citations by year
- 2026: 105 · 2025: 122 · 2024: 142 · 2023: 135 · 2022: 168 · 2021: 190 · 2020: 158 · 2019: 179 · 2018: 128 · 2017: 152 · 2016: 158 · 2015: 145 · 2014: 129 · 2013: 143 · 2012: 113
- FWCI
- 47.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA089054, R01CA107192)
- National Institute of Neurological Disorders and Stroke (R01NS045986)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Clinical Neurology › Myasthenia Gravis and Thymoma
- Keywords
- paraneoplastic encephalitis, anti-NMDA receptor encephalitis, ovarian teratoma, NMDA receptor subunits, NR2B, NR2A, autoantibodies, hippocampal neurons, autoimmune encephalitis, tumor resection, immunotherapy, microglial activation, neurodegeneration, psychiatric symptoms, amnesia, seizures
- MeSH terms
- Adolescent, Adult, Animals, Antibodies, Dissection, Encephalitis, Female, Humans, Immunohistochemistry, Immunosuppressive Agents, Magnetic Resonance Imaging, Male, Neurons, Ovarian Neoplasms, Teratoma, Transfection, Gene Expression Regulation, Neoplastic, Receptors, N-Methyl-D-Aspartate, Treatment Outcome, Rats, Wistar, Protein Subunits, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
