Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Monyer, Hannah; Burnashev, Nail; Laurie, David J.; Sakmann, Bert; Seeburg, Peter H.

doi:10.1016/0896-6273(94)90210-0

Cited by 2,989

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Monyer, Hannah, Burnashev, Nail, Laurie, David J., Sakmann, Bert, Seeburg, Peter H.·1994·Neuron

DOI 10.1016/0896-6273(94)90210-0

Open this paper in CoChat — free account

Abstract

An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the four NR2 transcripts display distinct expression patterns. NR2B and NR2D mRNAs occur prenatally, whereas NR2A and NR2C mRNAs are first detected near birth. All transcripts except NR2D peak around P20. NR2D mRNA, present mainly in midbrain structures, peaks around P7 and thereafter decreases to adult levels. Postnatally, NR2B and NR2C transcript levels change in opposite directions in the cerebellar internal granule cell layer. In the adult hippocampus, NR2A and NR2B mRNAs are prominent in CA1 and CA3 pyramidal cells, but NR2C and NR2D mRNAs occur in different subsets of interneurons. Recombinant binary NR1-NR2 channels show comparable Ca2+ permeabilities, but marked differences in voltage-dependent Mg2+ block and in offset decay time constants. Thus, the distinct expression profiles and functional properties of NR2 subunits provide a basis for NMDA channel heterogeneity in the brain.

Integrity signals

Registry

Crossref · 10.1016/0896-6273(94)90210-0

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

During postnatal brain development, NR2A expression rises while NR2B falls.
“During postnatal brain development, NR2A expression rises while NR2B falls (Monyer et al., 1994; Sheng et al., 1994).”
From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Monyer et al., 1994

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835 · see citing works
Patterned Activity, Synaptic Convergence, and the NMDA Receptor in Developing Visual Pathways
Constantine-Paton, M., Cline, H. T., & Debski, E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001021 · Cited by 784 · see citing works

Flagged first, then by citations

Sorted by citations

Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568 · see citing works
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
Paoletti, P., Bellone, C., & Zhou, Q. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3504 · Cited by 2,523 · see citing works
Paraneoplastic anti– N ‐methyl‐ <scp>D</scp> ‐aspartate receptor encephalitis associated with ovarian teratoma
Dalmau, J., Tüzün, E., Wu, H., Masjuan, J., Rossi, J. E., Voloschin, A., Baehring, J. M., Shimazaki, H., Koide, R., King, D., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21050 · Cited by 2,492 · see citing works
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055 · see citing works
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745 · see citing works
NMDA receptor subunits: diversity, development and disease
Cull-Candy, S., Brickley, S., & Farrant, M. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00215-4 · Cited by 1,694 · see citing works
Maternal care, hippocampal synaptogenesis and cognitive development in rats
Liu, D., Diorio, J., Day, J. C., Francis, D. D., & Meaney, M. J. (2000) · Nature Neuroscience · doi:10.1038/77702 · Cited by 1,195 · see citing works
Mechanisms of ketamine action as an antidepressant
Zanos, P., & Gould, T. D. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.255 · Cited by 1,127 · see citing works
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Neurosteroids: biosynthesis and function of these novel neuromodulators
Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820 · see citing works
NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo
Liu, Y., Wong, T. P., Aarts, M., Rooyakkers, A., Liu, L., Lai, T. W., Wu, D. C., Lu, J., Tymianski, M., Craig, A. M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0116-07.2007 · Cited by 773 · see citing works
Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
Edbauer, D., Neilson, J. R., Foster, K. A., Wang, C.-F., Seeburg, D. P., Batterton, M. N., Tada, T., Dolan, B. M., Sharp, P. A., & Sheng, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.005 · Cited by 735 · see citing works
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine
Borgland, S. L., Taha, S. A., Sarti, F., Fields, H. L., & Bonci, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.016 · Cited by 718 · see citing works
The role of the cerebellum in schizophrenia
Andreasen, N. C., & Pierson, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.003 · Cited by 669 · see citing works
Microglia: Dynamic Mediators of Synapse Development and Plasticity
Wu, Y., Dissing-Olesen, L., MacVicar, B. A., & Stevens, B. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.008 · Cited by 661 · see citing works
Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column.
Feldmeyer, D., Lübke, J., Silver, R. A., & Sakmann, B. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.012959 · Cited by 656 · see citing works
Self-citation
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649 · see citing works
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning
Blair, H. T., Schafe, G. E., Bauer, E. P., Rodrigues, S. M., & LeDoux, J. E. (2001) · Learning & Memory · doi:10.1101/lm.30901 · Cited by 610 · see citing works
Competitive binding of α-actinin and calmodulin to the NMDA receptor
Wyszynski, M., Lin, J., Rao, A., Nigh, E., Beggs, A. H., Craig, A. M., & Sheng, M. (1997) · Nature · doi:10.1038/385439a0 · Cited by 596 · see citing works
Molecular Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Cell Death
Sattler, R., & Tymianski, M. (2001) · Molecular Neurobiology · doi:10.1385/mn:24:1-3:107 · Cited by 537 · see citing works
The Role of NMDA Receptors in Alzheimer’s Disease
Liu, J., Chang, L., Song, Y., Li, H., & Wu, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00043 · Cited by 535 · see citing works
Subunit-Specific NMDA Receptor Trafficking to Synapses
Barria, A., & Malinow, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00776-6 · Cited by 515 · see citing works
GABAergic interneuron origin of schizophrenia pathophysiology
Nakazawa, K., Zsiros, V., Jiang, Z., Nakao, K., Kolata, S., Zhang, S., & Belforte, J. E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.022 · Cited by 498 · see citing works
Impairment of Suckling Response, Trigeminal Neuronal Pattern Formation, and Hippocampal LTD in NMDA Receptor ε2 Subunit Mutant Mice
Kutsuwada, T., Sakimura, K., Manabe, T., Takayama, C., Katakura, N., Kushiya, E., Natsume, R., Watanabe, M., Inoue, Y., Yagi, T., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80051-3 · Cited by 498 · see citing works
Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking
Kim, M. J., Dunah, A. W., Wang, Y. T., & Sheng, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.031 · Cited by 494 · see citing works
Molecular mechanisms underlying emotional learning and memory in the lateral amygdala
Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.014 · Cited by 491 · see citing works
NMDA-dependent modulation of CA1 local circuit inhibition
Grunze, H., Rainnie, D., Hasselmo, M., Barkai, E., Hearn, E., McCarley, R., & Greene, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02034.1996 · Cited by 467 · see citing works
Differential effects of acute and chronic exercise on plasticity‐related genes in the rat hippocampus revealed by microarray
Molteni, R., Ying, Z., & Gómez‐Pinilla, F. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02158.x · Cited by 441 · see citing works
Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia
Phillips, W. A., & Silverstein, S. M. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03000025 · Cited by 445 · see citing works
Reliable synaptic connections between pairs of excitatory layer 4 neurones within a single ‘barrel’ of developing rat somatosensory cortex
Feldmeyer, D., Egger, V., Lübke, J., & Sakmann, B. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00169.x · Cited by 441 · see citing works
Self-citation
Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
Feyissa, A. M., Chandran, A., Stockmeier, C. A., & Karolewicz, B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.005 · Cited by 421 · see citing works
Ca2+ Oscillations Mediated by the Synergistic Excitatory Actions of GABAA and NMDA Receptors in the Neonatal Hippocampus
Leinekugel, X., Medina, I., Khalilov, I., Ben-Ari, Y., & Khazipov, R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80265-2 · Cited by 407 · see citing works
N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer’s disease, vascular dementia and Parkinson’s disease
Olivares, D., K. Deshpande, V., Shi, Y., K. Lahiri, D., H. Greig, N., T. Rogers, J., & Huang, X. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322564 · Cited by 407 · see citing works
N-Methyl-d-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease
Waxman, E. A., & Lynch, D. R. (2005) · The Neuroscientist · doi:10.1177/1073858404269012 · Cited by 372 · see citing works
Mechanisms contributing to prefrontal cortex maturation during adolescence
Caballero, A., Granberg, R., & Tseng, K. Y. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.013 · Cited by 357 · see citing works
A Specific Role for NR2A-Containing NMDA Receptors in the Maintenance of Parvalbumin and GAD67 Immunoreactivity in Cultured Interneurons
Kinney, J. W., Davis, C. N., Tabarean, I., Conti, B., Bartfai, T., & Behrens, M. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4722-05.2006 · Cited by 329 · see citing works
Distinct roles for spontaneous and visual activity in remodeling of the retinogeniculate synapse
Hooks, B. M., & Chen, C. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.007 · Cited by 311 · see citing works
Genetic and activity-dependent mechanisms underlying interneuron diversity
Wamsley, B., & Fishell, G. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.30 · Cited by 290 · see citing works
Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development
Compagnone, N. A., & Mellon, S. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4678 · Cited by 327 · see citing works
Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies
Oyrer, J., Maljevic, S., Scheffer, I. E., Berkovic, S. F., Petrou, S., & Reid, C. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014456 · Cited by 315 · see citing works
Classification of fusiform neocortical interneurons based on unsupervised clustering
Cauli, B., Porter, J. T., Tsuzuki, K., Lambolez, B., Rossier, J., Quenet, B., & Audinat, E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6144 · Cited by 316 · see citing works
NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 Area
Racca, C., Stephenson, F. A., Streit, P., Roberts, J. D. B., & Somogyi, P. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02512.2000 · Cited by 304 · see citing works
Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters
Boulland, J., Qureshi, T., Seal, R. P., Rafiki, A., Gundersen, V., Bergersen, L. H., Fremeau, R. T., Edwards, R. H., Storm‐Mathisen, J., & Chaudhry, F. A. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20354 · Cited by 280 · see citing works
Development of Excitatory Circuitry in the Hippocampus
Hsia, A. Y., Malenka, R. C., & Nicoll, R. A. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.2013 · Cited by 279 · see citing works
Synaptic Signaling in Learning and Memory
Kennedy, M. B. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016824 · Cited by 270 · see citing works
Prenatal stressors in rodents: Effects on behavior
Weinstock, M. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.004 · Cited by 264 · see citing works
Influence of GluN2 subunit identity on NMDA receptor function
Wyllie, D. J. A., Livesey, M. R., & Hardingham, G. E. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.01.016 · Cited by 260 · see citing works
Ketamine: NMDA Receptors and Beyond
Zorumski, C. F., Izumi, Y., & Mennerick, S. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1547-16.2016 · Cited by 254 · see citing works
Multiple Structural Elements Determine Subunit Specificity of Mg2+Block in NMDA Receptor Channels
Kuner, T., & Schoepfer, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03549.1996 · Cited by 235 · see citing works
Deep molecular diversity of mammalian synapses: why it matters and how to measure it
O'Rourke, N. A., Weiler, N. C., Micheva, K. D., & Smith, S. J. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3170 · Cited by 210 · see citing works
Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons
Mann, E. O., & Mody, I. (2010) · Nature Neuroscience · doi:10.1038/nn.2464 · Cited by 222 · see citing works
NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein Reelin
Groc, L., Choquet, D., Stephenson, F. A., Verrier, D., Manzoni, O. J., & Chavis, P. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1772-07.2007 · Cited by 225 · see citing works
Neurosteroid regulation of central nervous system development
Mellon, S. H. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.011 · Cited by 209 · see citing works
Rethinking schizophrenia in the context of normal neurodevelopment
Catts, V. S., Fung, S. J., Long, L. E., Joshi, D., Vercammen, A., Allen, K. M., Fillman, S. G., Rothmond, D. A., Sinclair, D., Tiwari, Y., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00060 · Cited by 206 · see citing works
Obligatory Role of NR2A for Metaplasticity in Visual Cortex
Philpot, B. D., Cho, K. K. A., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.027 · Cited by 207 · see citing works
The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation
Finnie, P. S. B., & Nader, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.008 · Cited by 189 · see citing works
Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor
Fontán-Lozano, Á., Sáez-Cassanelli, J. L., Inda, M. C., de los Santos-Arteaga, M., Sierra-Domínguez, S. A., López-Lluch, G., Delgado-García, J. M., & Carrión, Á. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2757-07.2007 · Cited by 195 · see citing works
Properties of bipolar VIPergic interneurons and their excitation by pyramidal neurons in the rat neocortex
Porter, J. T., Cauli, B., Staiger, J. F., Lambolez, B., Rossier, J., & Audinat, E. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00367.x · Cited by 173 · see citing works
A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function
Wang, C.-C., Held, R. G., Chang, S.-C., Yang, L., Delpire, E., Ghosh, A., & Hall, B. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.023 · Cited by 180 · see citing works
Sleep deprivation‐induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus
McDermott, C. M., Hardy, M. N., Bazan, N. G., & Magee, J. C. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093781 · Cited by 178 · see citing works
d-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning
Duffy, S., Labrie, V., & Roder, J. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301486 · Cited by 173 · see citing works
NMDA Receptor GluN2B (GluRε2/NR2B) Subunit Is Crucial for Channel Function, Postsynaptic Macromolecular Organization, and Actin Cytoskeleton at Hippocampal CA3 Synapses
Akashi, K., Kakizaki, T., Kamiya, H., Fukaya, M., Yamasaki, M., Abe, M., Natsume, R., Watanabe, M., & Sakimura, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5531-08.2009 · Cited by 163 · see citing works
Post-pubertal Emergence of Prefrontal Cortical Up States Induced by D1-NMDA Co-activation
Tseng, K. Y. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh107 · Cited by 169 · see citing works
Neuronal Transporters Regulate Glutamate Clearance, NMDA Receptor Activation, and Synaptic Plasticity in the Hippocampus
Scimemi, A., Tian, H., & Diamond, J. S. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4845-09.2009 · Cited by 169 · see citing works
Differential role of NR2A and NR2B subunits in N-Methyl-D-Aspartate receptor antagonist-induced aberrant cortical gamma oscillations
Kocsis, B. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.002 · Cited by 159 · see citing works
Neuroadaptive processes in GABAergic and glutamatergic systems in benzodiazepine dependence
Allison, C., & Pratt, J. A. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00029-9 · Cited by 160 · see citing works
Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex
Suzuki, M., Wright, L. S., Marwah, P., Lardy, H. A., & Svendsen, C. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307325101 · Cited by 152 · see citing works
Distinct NMDA Receptors Provide Differential Modes of Transmission at Mossy Fiber-Interneuron Synapses
Lei, S., & McBain, C. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00608-6 · Cited by 150 · see citing works
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
Vieira, M., Yong, X. L. H., Roche, K. W., & Anggono, V. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14970 · Cited by 151 · see citing works
“For example while the overall expression level of GluN2C and GluN2D is low in the cortex and hippocampus, they are specifically expressed in interneurons and glial cells (Monyer et al., 1994; Perszyk, DiRaddo, & Strong, 2016).”
BackgroundInfluential
Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity
Lau, C. G., Takeuchi, K., Rodenas-Ruano, A., Takayasu, Y., Murphy, J., Bennett, M. V. L., & Zukin, R. S. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371369 · Cited by 138 · see citing works
Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia†
Greene, R. (2001) · Hippocampus · doi:10.1002/hipo.1072 · Cited by 140 · see citing works
Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors
Matsuda, K., Fletcher, M., Kamiya, Y., & Yuzaki, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10064.2003 · Cited by 138 · see citing works
Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex
Ampuero, E., Rubio, F. J., Falcon, R., Sandoval, M., Diaz-Veliz, G., Gonzalez, R. E., Earle, N., Dagnino-Subiabre, A., Aboitiz, F., Orrego, F., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.035 · Cited by 132 · see citing works
Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal MaturationIn Vitro
Sinagra, M., Verrier, D., Frankova, D., Korwek, K. M., Blahos, J., Weeber, E. J., Manzoni, O. J., & Chavis, P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1757-05.2005 · Cited by 128 · see citing works
GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity
Perszyk, R. E., DiRaddo, J. O., Strong, K. L., Low, C.-M., Ogden, K. K., Khatri, A., Vargish, G. A., Pelkey, K. A., Tricoire, L., Liotta, D. C., et al. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.105130 · Cited by 116 · see citing works
Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats
Yaka, R., Salomon, S., Matzner, H., & Weinstock, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.018 · Cited by 120 · see citing works
A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex
Aramakis, V. B., Hsieh, C. Y., Leslie, F. M., & Metherate, R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06106.2000 · Cited by 120 · see citing works
Gut microbiota of mice putatively modifies amino acid metabolism in the host brain
Kawase, T., Nagasawa, M., Ikeda, H., Yasuo, S., Koga, Y., & Furuse, M. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517000678 · Cited by 119 · see citing works
Potential roles of zinc in the pathophysiology and treatment of major depressive disorder
Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., & Lanctôt, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.018 · Cited by 116 · see citing works
Glutamate Acting on AMPA But Not NMDA Receptors Modulates the Migration of Hippocampal Interneurons
Manent, J.-B., Jorquera, I., Ben-Ari, Y., Aniksztejn, L., & Represa, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1033-06.2006 · Cited by 112 · see citing works
Decline of the Critical Period of Visual Plasticity Is Concurrent with the Reduction of NR2B Subunit of the Synaptic NMDA Receptor in Layer 4
Erisir, A., & Harris, J. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05208.2003 · Cited by 111 · see citing works
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
Ferreira, J. S., Papouin, T., Ladépêche, L., Yao, A., Langlais, V. C., Bouchet, D., Dulong, J., Mothet, J.-P., Sacchi, S., Pollegioni, L., et al. (2017) · eLife · doi:10.7554/elife.25492 · Cited by 110 · see citing works
Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex
Henson, M. A., Roberts, A. C., Salimi, K., Vadlamudi, S., Hamer, R. M., Gilmore, J. H., Jarskog, L. F., & Philpot, B. D. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn017 · Cited by 110 · see citing works
GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice
Engelhardt, J. V., Bocklisch, C., TÃ¶nges, L., Herb, A., Mishina, M., & Monyer, H. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00095 · Cited by 103 · see citing works
Self-citation
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus
Vasuta, C., Caunt, C., James, R., Samadi, S., Schibuk, E., Kannangara, T., Titterness, A. K., & Christie, B. R. (2007) · Hippocampus · doi:10.1002/hipo.20349 · Cited by 105 · see citing works
Breakdown of effective connectivity during slow wave sleep: investigating the mechanism underlying a cortical gate using large-scale modeling
Esser, S. K., Hill, S., & Tononi, G. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00059.2009 · Cited by 97 · see citing works
Adolescent neurodevelopment and substance use: receptor expression and behavioral consequences
Thorpe, H. H. A., Hamidullah, S., Jenkins, B. W., & Khokhar, J. Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107431 · Cited by 97 · see citing works
Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis
Campo, C. G., Sinagra, M., Verrier, D., Manzoni, O. J., & Chavis, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005505 · Cited by 100 · see citing works
Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex
Gonzalez-Burgos, G., Kroener, S., Zaitsev, A. V., Povysheva, N. V., Krimer, L. S., Barrionuevo, G., & Lewis, D. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm095 · Cited by 95 · see citing works
Diverse roles for ionotropic glutamate receptors on inhibitory interneurons in developing and adult brain
Akgül, G., & McBain, C. J. (2016) · The Journal of Physiology · doi:10.1113/jp271764 · Cited by 87 · see citing works
Growth hormone replacement in hypophysectomized rats affects spatial performance and hippocampal levels of NMDA receptor subunit and PSD-95 gene transcript levels
Le Grevès, M., Zhou, Q., Berg, M., Le Grevès, P., Fhölenhag, K., Meyerson, B., & Nyberg, F. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0438-2 · Cited by 92 · see citing works
Identification of Tbr-1/CASK complex target genes in neurons
Wang, T., Ding, C., Wang, G., Luo, S., Lin, Y., Ruan, Y., Hevner, R., Rubenstein, J. L. R., & Hsueh, Y. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02845.x · Cited by 83 · see citing works
Increasing the GluN2A/GluN2B ratio in neurons of the mouse basal and lateral amygdala inhibits the modification of an existing fear memory trace
Holehonnur, R., Phensy, A. J., Kim, L. J., Milivojevic, M., Vuong, D., Daison, D. K., Alex, S., Tiner, M., Jones, L. E., Kroener, S., et al. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1743-16.2016 · Cited by 74 · see citing works
The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes: Oligodendrocyte NMDA responses
Burzomato, V., Frugier, G., Pérez-Otaño, I., Kittler, J. T., & Attwell, D. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.195503 · Cited by 78 · see citing works
Development of Thalamocortical Connections between the Mediodorsal Thalamus and the Prefrontal Cortex and Its Implication in Cognition
Ferguson, B. R., & Gao, W.-J. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.01027 · Cited by 75 · see citing works
Rapid eye movement sleep deprivation decreases long-term potentiation stability and affects some glutamatergic signaling proteins during hippocampal development
Lopez, J., Roffwarg, H. P., Dreher, A., Bissette, G., Karolewicz, B., & Shaffery, J. P. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.072 · Cited by 71 · see citing works
Developmental synaptic plasticity at the thalamocortical input to barrel cortex: Mechanisms and roles
Daw, M. I., Scott, H. L., & Isaac, J. T. R. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.001 · Cited by 70 · see citing works

Authors: Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H.
Venue: Neuron
Publisher: Elsevier BV
Published: 1994-03
Volume: 12
Issue: 3
Pages: 529-540
ISSN: 0896-6273
DOI: 10.1016/0896-6273(94)90210-0
Cited by: 2,989
References: 2
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Record

About these checks