The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia
Open accessAbstract
Objective: To identify predictors of Alzheimer's disease (AD) versus frontotemporal lobar degeneration pathology in primary progressive aphasia (PPA), and determine whether the AD pathology is atypically distributed to fit the aphasic phenotype. Methods: Neuropsychological and neuropathological analyses of 23 consecutive PPA autopsies. All had qualitative determination of neurofibrillary tangle (NFT) density. Additional quantitation was done in four of the PPA/AD cases and four AD cases with the typical amnestic dementia of the Alzheimer type. Results: The sample contained mostly logopenic, agrammatic, and mixed forms of PPA. All six agrammatics had frontotemporal lobar degeneration (five of six with tauopathy). Seven of the 11 logopenics had AD. In logopenics, lower memory scores increased the probability of AD, but there were exceptions. The PPA/AD group showed predominance of entorhinal NFT typical of the amnestic dementia of the Alzheimer type. In the small subgroup examined quantitatively, neocortical NFTs were more numerous in the left hemisphere of PPA/AD. However, the asymmetry was low and inconsistent. Neuritic plaques did not display consistent asymmetry. Apolipoprotein E4, a major risk factor for typical AD, did not predict AD pathology in PPA. Interpretation: Subtyping PPA helps to predict AD versus frontotemporal lobar degeneration pathology at the group level. However, our results and the literature also indicate that no clinical predictor is completely reliable in individual patients. The inconsistent concordance of NFT distribution with the asymmetric atrophy and the nonamnestic phenotype also raises the possibility that the AD markers encountered at autopsy in PPA may not always reflect the nature of the initiating neurodegenerative process. Ann Neurol 2008
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
A compendium of neuropsychological tests: administration, norms, and commentary
(1991) · Choice Reviews Online · doi:10.5860/choice.29-2400 · Cited by 6,118
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary
Levin, H. S. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540050007005 · Cited by 4,796
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Cognition and anatomy in three variants of primary progressive aphasia
Gorno‐Tempini, M. L., Dronkers, N. F., Rankin, K. P., Ogar, J. M., Phengrasamy, L., Rosen, H. J., Johnson, J. K., Weiner, M. W., & Miller, B. L. (2004) · Annals of Neurology · doi:10.1002/ana.10825 · Cited by 1,657
Flagged first, then by citations
Research works printed but not linked: 4
- Mesulam M‐M, 1992, Unusual Dementias, 583
- Wechsler D, 1987, Wechsler Memory Scale‐Revised Manual
- Kaplan E, 1983, The Boston Naming Test
- Warrington E, 1984, Recognition Memory Test manual
Cited by
Sorted by citations
Items 401–500 of 513
Atypical parkinsonism, parkinsonism-plus syndromes and secondary parkinsonian disorders
Jankovic, J. J., Hallett, M., Okun, M. S., Comella, C., Fahn, S., & Goldman, J. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-31071-0.00009-3 · Cited by 2
Gill, D. J., & Damann, K. M. (2015) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000466657.97531.af · Cited by 2
Basilico, S., Ciricugno, A., Gelosa, G., Magnani, F. G., Mosca, L., Popescu, C. E., Garibotto, V., Sberna, M., Paulesu, E., & Bottini, G. (2021) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000273 · Cited by 2
Aphasia and related impairments pertaining to FTLD
Otsuki, M. (2012) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.52.1224 · Cited by 2
Prevalence of cerebrospinal fluid Alzheimer disease-like pattern in atypical dementias
Padovani, A., Benussi, A., Ferrari, F., Archetti, S., & Borroni, B. (2012) · Advances in Alzheimer s Disease · doi:10.4236/aad.2012.13006 · Cited by 2
Primary progressive aphasia : symptomatological correlations
Komori, K. (2012) · Higher Brain Function Research · doi:10.2496/hbfr.32.393 · Cited by 2
Atypical parkinsonism, parkinsonism-plus syndromes, and secondary parkinsonian disorders
Fahn, S., Jankovic, J. J., & Hallett, M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2369-4.00009-3 · Cited by 2
Spinelli, E. G., Tempini, M. L. G., & Shapiro, K. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800105-9.00032-9 · Cited by 2
Viader, F., Lambert, J., Sayette, V. D. L., Eustache, F., Morin, P., Morin, I., & Lechevalier, B. (2010) · Encyclopédie médico-chirurgicale. Neurologie · doi:10.1016/s0246-0378(09)51369-3 · Cited by 2
Afasias progresivas primarias: las afasias de lenta evolución a demencia.
Custodio, N., Castro, S., Herrera‐Pérez, E., Lira, D., del Prado, L. N., Cortijo, P., & Montesinos, R. (2013) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v75i3.1227 · Cited by 2
Demencia frontotemporal: fronteras diagnósticas
Lancho, M. C. P., & Bercianos, S. G. (2018) · International Journal of Developmental and Educational Psychology Revista INFAD de psicología · doi:10.17060/ijodaep.2018.n1.v4.1267 · Cited by 1
The Psychopathology and Neuropsychology of Alzheimer’s Disease: A New Narrative
Barakat, M., Annan, I., Sader, A., & Khoury, R. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_54-1 · Cited by 1
The role of nuclear medicine in central nervous system evaluation
Shadmani, G., Swingle, C. A., & Coffman, C. H. (2025) · The Neuroradiology Journal · doi:10.1177/19714009251345100 · Cited by 1
Utianski, R. L., Meade, G. F., Duffy, J. R., & Botha, H. (2026) · American Journal of Speech-Language Pathology · doi:10.1044/2025_ajslp-25-00251 · Cited by 1
Cunha, E. D., Manera, V., Chorin, F., Lemaire, J., Plonka, A., Mouton, A., Zory, R., & Gros, A. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2026.100573 · Cited by 1
FDG-PET in the Evaluation of Primary Progressive Aphasia: A Narrative Review
Giannakis, A., Anyfantis, E., Litsou, E. V., Sioka, C., & Konitsiotis, S. (2026) · Medicina · doi:10.3390/medicina62050800 · Cited by 1
Tian, Y., & Whitwell, J. L. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121984 · Cited by 2
Candela, S., Giubilei, F., & Orzi, F. (2013) · PubMed · Cited by 1
Primary Progressive Aphasia: Clinical, Imaging, and Neuropathological Findings
Gliebus, G. P. (2010) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317509356691 · Cited by 1
Primary Progressive Aphasia and Its Three Variants
Ogar, J. M. (2010) · Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders · doi:10.1044/nnsld20.1.5 · Cited by 1
Awad, S. M., & Awad, A. M. (2011) · Case Reports in Neurological Medicine · doi:10.1155/2011/450301 · Cited by 1
Troubles du langage et pathologies neurodégénératives
Hommet, C., Perrier, D., Beaufils, É., Constans, T., & Mondon, K. (2012) · Soins Gérontologie · doi:10.1016/j.sger.2012.05.005 · Cited by 1
Advances in Alzheimer’s Disease Management
Gauthier, S. G., & Rosa‐Neto, P. (2012) · doi:10.2217/9781780840840 · Cited by 1
The Cerebral Cortex and Complex Cerebral Functions
ten Donkelaar, H. J. (2011) · Springer eBooks · doi:10.1007/978-3-642-19134-3_15 · Cited by 1
Herrera, E., Acevedo, C., & González-Nosti, M. (2024) · Geriatrics · doi:10.3390/geriatrics10010002 · Cited by 2
Frontotemporal Dementia (FTD) 2011
Kertesz, A. (2011) · Acta Neuropsychologica · doi:10.5604/01.3001.0001.0773 · Cited by 3
Progressive Apraxia of Speech and Primary Progressive Aphasias
Josephs, K. A., & Whitwell, J. L. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6365-7_13 · Cited by 1
(2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.006 · Cited by 1
Overview of frontotemporal dementia and its relationship to other neurodegenerative disorders
Mcmonagle, P., & Kertesz, A. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.005 · Cited by 2
Frontotemporal Lobar Degeneration
Filippi, M., & Agosta, F. (2021) · Springer eBooks · doi:10.1007/978-3-030-66773-3_3 · Cited by 1
Behavior Symptoms in Primary Progressive Aphasia Variants
Maruta, C., Marôco, J. P., de Mendonça, A., & Guerreiro, M. (2016) · Neuropsychiatric symptoms of neurological disease · doi:10.1007/978-3-319-39138-0_3 · Cited by 2
C9orf72 Repeat Expansion Does Not Affect the Phenotype in Primary Progressive Aphasia
Haapanen, M., Katisko, K., Hänninen, T., Krüger, J., Hartikainen, P. H., Haapasalo, A., Remes, A. M., & Solje, E. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200795 · Cited by 1
Mesulam, M. M. (2016) · Cambridge University Press eBooks · doi:10.1017/9781139924771.011 · Cited by 1
Self-citationSpoken discourse in Alzheimer' disease: a review
Ahmed, S., & Garrard, P. (2012) · Linguistica · doi:10.4312/linguistica.52.1.9-25 · Cited by 3
Ancestralidade da população de São Paulo e correlação com alterações neuropatológicas no idoso
Schlesinger, D. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2010.tde-17122010-142628 · Cited by 1
Nishida, H., Hayashi, Y., Ban, Y., Kudo, T., Harada, N., & Sakurai, T. (2019) · Internal Medicine · doi:10.2169/internalmedicine.2301-18 · Cited by 1
RetractedShatz, R. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_915 · Cited by 1
Speech Features for Monitoring Alzheimer’s Disease Using Random Forest Classifier
Hason, L. (2024) · doi:10.32920/25412647 · Cited by 1
Cognitive Impairment and the Dementias
Duara, R., Rodriguez, M. J., Loewenstein, D., Farlow, M. R., Ballard, C. G., Chui, H. C., Segal‐Gidan, F., Perry, D. C., Rosen, H. J., Henry, M. L., et al. (2014) · Wiley eBooks · doi:10.1002/9781118730676.ch9 · Cited by 1
Progressive aphasia complicated by intracerebral bleeding
Léger, G. C. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511997433.013
Self-citationProgressive aphasia: Patterns of language behavior and regional cortical atrophy
Henry, M. L. (2009) · UA Campus Repository (The University of Arizona)
Avaliação fonoaudiológica da deglutição na demência frontotemporal
Marin, S. D. M. C. (2014) · doi:10.11606/t.5.2014.tde-26082014-111637
Thomas-Antérion, C., & Mahieux, F. (2009) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2009.04.008
Dificultades en la afasia progresiva primaria. A propósito de un caso
Benabarre, S., Gascón, M. C., Pueyo, J. O., & Valero, C. P. (2011) · Boletín de AELFA · doi:10.1016/s1137-8174(11)70040-1
Filippi, M., Agosta, F., & Spinelli, E. G. (2015) · Springer eBooks · doi:10.1007/978-1-4939-3118-7_17
Chronisch progrediente Aphasien
Verlag, S. M. (2009)
Nosologie des dégénérescences lobaires frontotemporales
Hannequin, D., Wallon, D., Martinaud, O., Maltête, D., Deramecourt, V., Campion, D., & Ber, I. L. (2011) · Pratique Neurologique - FMC · doi:10.1016/j.praneu.2011.02.009
Afasia progresiva primaria: reporte de un caso
Torres Ramírez, L., Ecos Quispe, R., Vélez Rojas, M., & Cosentino Esquerre, C. (2012)
Dickerson, B. C. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.019
Kim, H. J., Kim, T. E., Kim, S., Chae, W. S., & Park, S. A. (2014) · Journal of the Korean Neurological Association
Introduction to and brief history of FTD
Dickerson, B. C. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.004
Neuroimaging of other dementing disorders
Hu, W. T., & Grossman, M. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511782091.028
Hannequin, D., Wallon, D., Martinaud, O., Maltête, D., Deramecourt, V., & Campion, D. (2015)
Diagnosis of Alzheimer’s disease
Rosa‐Neto, P., Rowley, J., Leuzy, A., Mohades, S., Shin, M., Dauar, M. T., & Gauthier, S. G. (2012) · doi:10.2217/ebo.12.66
Language Rehabilitation in Alzheimer's Disease-Verbal Fluency Clusters
Giacominelli, C., Bezerra, S. T., Barcelos, L. B., Pereira, F. H., & Bertolucci, P. H. F. (2017) · Journal of Novel Physiotherapies · doi:10.4172/2165-7025.1000373
Sjödin, S. (2018) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Preservation of Memory in Alzheimer-Related Primary Progressive Aphasia
Sajjadi, S. A., Ash, S., & Cappa, S. F. (2021) · Neurology · doi:10.1212/wnl.0000000000011404
McKeever, P. M. (2018) · TSpace (University of Toronto)
Revisão de intervenções cognitivas em pacientes com Afasia Progressiva Primária
Vieira, K. R., de Carvalho, A. C. R., & Miotto, E. C. (2021) · Revista Neurociências · doi:10.34024/rnc.2021.v29.12122 · Cited by 1
Imam, I. (2021) · CRC Press eBooks · doi:10.1201/9781003221258-6
Deramecourt, V. (2009) · HAL
Post-stroke and Progressive Aphasia
Meier, E. L., Sebastian, R., & Hillis, A. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00112-2
Bertoux, M., O’Callaghan, C., Flanagan, E. C., & Hornberger, M. (2017) · Springer eBooks · doi:10.1007/978-981-287-082-7_311 · Cited by 1
Nagaratnam, N., Nagaratnam, K., & Cheuk, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-33434-9_71
Frontotemporal Lobar Degenerations
Johnson, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-56782-2_506-2
Self-citationMusil, S., & Johnson, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_508
Self-citationJohnson, N., & Borosh, B. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_511
Self-citationMusil, S., & Johnson, N. (2010) · Springer eBooks · doi:10.1007/978-0-387-79948-3_508
Self-citationJohnson, N., & Musil, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_509
Self-citationJohnson, N., & Borosh, B. (2018) · Springer eBooks · doi:10.1007/978-3-319-56782-2_511-2
Self-citationTippett, D. C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733957136.793569912
Johnson, N., & Musil, S. (2010) · Springer eBooks · doi:10.1007/978-0-387-79948-3_509
Self-citationShatz, R. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-56782-2_915-3
Roberts, A., RADEMAKER, A. W., Salley, E., Mooney, A. R., Morhardt, D., Fried-Oken, M. B., Weıntraub, S., Mesulam, M. M., & Rogalski, E. J. (2021) · Research Square · doi:10.21203/rs.3.rs-759360/v1
Self-citationJohnson, N., & Borosh, B. (2010) · Springer eBooks · doi:10.1007/978-0-387-79948-3_511
Self-citationMusil, S., & Johnson, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-56782-2_508-2
Self-citationTippett, D. C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727252046.793569911
Frontotemporal Lobar Degenerations
Johnson, N. (2010) · Springer eBooks · doi:10.1007/978-0-387-79948-3_506
Self-citationJohnson, N., & Musil, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-56782-2_509-2
Self-citationFrontotemporal Lobar Degenerations
Johnson, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_506
Self-citationAdvances in Primary Progressive Aphasia
Matías‐Guiu, J. A., Laforce, R. J., & Utianski, R. L. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-4407-6
Logopenic Variant Primary Progressive Aphasia
Song, L. (2022) · Springer eBooks · doi:10.1007/978-3-030-12852-4_99-1
The Clinical Manifestation of Primary Progressive Aphasia
Mathew, C. (2023) · International Journal of Psychiatry Research · doi:10.33425/2641-4317.1152
Jargonaphasia in logopenic variant primary progressive aphasia
Mendez, M. F., Sheppard, A., Chávez, D., & Holiday, K. A. (2023) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2023.120779
Recent advances in frontotemporal dementia
Devenney, E. M., & Hodges, J. R. (2016) · Advances in Clinical Neuroscience & Rehabilitation · doi:10.47795/qnre6582
Schaffer, K. M., & Henry, M. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00125-x
Frucht, S. J., & Termsarasab, P. (2024) · Springer eBooks · doi:10.1007/978-3-031-52573-5_6
Afasia progressiva non fluente/agrammatica e aprassia della parola primaria progressiva
Teichmann, M. (2024) · EMC - Neurologia · doi:10.1016/s1634-7072(24)49340-9
Degenerazioni lobari frontotemporali: neuropatologia, genetica e classificazione
Saracino, D., Ber, I. L., & Deramecourt, V. (2024) · EMC - Neurologia · doi:10.1016/s1634-7072(24)49339-2
Pause Characteristics by Utterance Position in Patients with Primary Progressive Aphasia Subtypes
Kim, H. S., Kim, D. Y., Ye, B. S., & Kim, H. (2024) · Eon'eo cheong'gag jang'ae yeon'gu/Communication sciences & disorders · doi:10.12963/csd.240077
21 Basics of Acquired Language Disorders: Aphasia
Cappa, S. F., Ginocchio, D., Maciejewska, B., Mozzanica, F., & Schindler, A. (2025) · European manual of medicine · doi:10.1007/978-3-031-48091-1_6
Thanh, N. N. T., Ha, H., Thanh, H. P., Thi, L. N., Trong, N. H. T., & Hoai, T. (2025) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-031-90197-3_37
Transkranielle Gleichstromstimulation bei primär progressiver Aphasie
Tippett, D. C., & Tsapkini, K. (2025) · Springer eBooks · doi:10.1007/978-3-662-70454-7_18
The Psychopathology and Neuropsychology of Alzheimer’s Disease: A New Narrative
Barakat, M., Annan, I., Sader, A., & Khoury, R. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_54
Abdi, Z., Harding, E., Pelak, V. S., Yong, K. X. X., & Crutch, S. J. (2025) · Cambridge University Press eBooks · doi:10.1017/9781108985055.016
Koenig, K. A., Huang, X., Bonner‐Jackson, A., Leverenz, J. B., Lowe, M. J., & Pillai, J. A. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251392928
Nascimento, C. F. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2015.tde-18062015-114710
Afasias primarias progresivas. Caracterización clínica y marcadores biológicos
Navarro, S. (2013) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Metadata
- Authors
- Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Léger, G. C., Rademaker, A., Weintraub, S., & Bigio, E. H.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Mesulam, Marsel
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2008-04-15
- Volume
- 63
- Issue
- 6
- Pages
- 709-719
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC2858311
- OpenAlex
- W2135496343
- Cited by
- 513
- References
- 54
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 18 · 2023: 14 · 2022: 18 · 2021: 23 · 2020: 28 · 2019: 28 · 2018: 32 · 2017: 29 · 2016: 24 · 2015: 31 · 2014: 31 · 2013: 54 · 2012: 43
- FWCI
- 25.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG13854, P30AG013854)
- National Institute on Deafness and Other Communication Disorders (R01DC008552, DC008552)
- National Center for Research Resources (UL1RR025741)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- primary progressive aphasia, Alzheimer's disease, frontotemporal lobar degeneration, neurofibrillary tangles, entorhinal cortex, logopenic aphasia, agrammatic aphasia, APOE ε4, neuritic plaques, hemispheric lateralization, neuropathology, differential diagnosis
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Brain, Dementia, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Degeneration, Neurons, Phenotype, Biomarkers, Neurofibrillary Tangles, Disease Progression, Aphasia, Primary Progressive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
