Cited by 513Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

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Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia

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Mesulam, Marsel, Wicklund, Alissa, Johnson, Nancy, Rogalski, Emily, Léger, Gabriel C., Rademaker, Alfred, Weintraub, Sandra, Bigio, Eileen H.·2008·Annals of Neurology

DOI 10.1002/ana.21388PMC PMC2858311

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Abstract

Objective: To identify predictors of Alzheimer's disease (AD) versus frontotemporal lobar degeneration pathology in primary progressive aphasia (PPA), and determine whether the AD pathology is atypically distributed to fit the aphasic phenotype. Methods: Neuropsychological and neuropathological analyses of 23 consecutive PPA autopsies. All had qualitative determination of neurofibrillary tangle (NFT) density. Additional quantitation was done in four of the PPA/AD cases and four AD cases with the typical amnestic dementia of the Alzheimer type. Results: The sample contained mostly logopenic, agrammatic, and mixed forms of PPA. All six agrammatics had frontotemporal lobar degeneration (five of six with tauopathy). Seven of the 11 logopenics had AD. In logopenics, lower memory scores increased the probability of AD, but there were exceptions. The PPA/AD group showed predominance of entorhinal NFT typical of the amnestic dementia of the Alzheimer type. In the small subgroup examined quantitatively, neocortical NFTs were more numerous in the left hemisphere of PPA/AD. However, the asymmetry was low and inconsistent. Neuritic plaques did not display consistent asymmetry. Apolipoprotein E4, a major risk factor for typical AD, did not predict AD pathology in PPA. Interpretation: Subtyping PPA helps to predict AD versus frontotemporal lobar degeneration pathology at the group level. However, our results and the literature also indicate that no clinical predictor is completely reliable in individual patients. The inconsistent concordance of NFT distribution with the asymmetric atrophy and the nonamnestic phenotype also raises the possibility that the AD markers encountered at autopsy in PPA may not always reflect the nature of the initiating neurodegenerative process. Ann Neurol 2008

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Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
A compendium of neuropsychological tests: administration, norms, and commentary
(1991) · Choice Reviews Online · doi:10.5860/choice.29-2400 · Cited by 6,118
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary
Levin, H. S. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540050007005 · Cited by 4,796
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130
Primary Progressive Aphasia
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Cognition and anatomy in three variants of primary progressive aphasia
Gorno‐Tempini, M. L., Dronkers, N. F., Rankin, K. P., Ogar, J. M., Phengrasamy, L., Rosen, H. J., Johnson, J. K., Weiner, M. W., & Miller, B. L. (2004) · Annals of Neurology · doi:10.1002/ana.10825 · Cited by 1,657

Show all 54 references

Research works printed but not linked: 4

Mesulam M‐M, 1992, Unusual Dementias, 583
Wechsler D, 1987, Wechsler Memory Scale‐Revised Manual
Kaplan E, 1983, The Boston Naming Test
Warrington E, 1984, Recognition Memory Test manual

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Self-citation
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Self-citation
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Authors: Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Léger, G. C., Rademaker, A., Weintraub, S., & Bigio, E. H.
Affiliations: Northwestern University (US)
Corresponding author: Mesulam, Marsel
ORCID: Mesulam, Marsel
Wicklund, Alissa
Johnson, Nancy
Rogalski, Emily
Léger, Gabriel C.
Rademaker, Alfred
Bigio, Eileen H.
Venue: Annals of Neurology
Publisher: Wiley
Published: 2008-04-15
Volume: 63
Issue: 6
Pages: 709-719
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.21388
PMC: PMC2858311
OpenAlex: W2135496343
Cited by: 513
References: 54
Citations by year: 2026: 16 · 2025: 14 · 2024: 18 · 2023: 14 · 2022: 18 · 2021: 23 · 2020: 28 · 2019: 28 · 2018: 32 · 2017: 29 · 2016: 24 · 2015: 31 · 2014: 31 · 2013: 54 · 2012: 43
FWCI: 25.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG13854, P30AG013854)
National Institute on Deafness and Other Communication Disorders (R01DC008552, DC008552)
National Center for Research Resources (UL1RR025741)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: primary progressive aphasia, Alzheimer's disease, frontotemporal lobar degeneration, neurofibrillary tangles, entorhinal cortex, logopenic aphasia, agrammatic aphasia, APOE ε4, neuritic plaques, hemispheric lateralization, neuropathology, differential diagnosis
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Brain, Dementia, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Degeneration, Neurons, Phenotype, Biomarkers, Neurofibrillary Tangles, Disease Progression, Aphasia, Primary Progressive

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Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia

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