The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A 3‐year magnetic resonance imaging study of cortical lesions in relapse‐onset multiple sclerosis
Abstract
Objective: We assessed the occurrence, extent, and frequency of formation of cortical lesions (CLs) in patients with relapsing‐remitting (RR) and secondary progressive (SP) multiple sclerosis (MS), and their relationship with cortical atrophy and disability progression. Methods: One‐hundred seven MS patients (76 RRMS and 31 SPMS), enrolled in a prospective, longitudinal magnetic resonance imaging (MRI) study, were assessed clinically and by brain MRI (including a double inversion recovery sequence) 3 years after study initiation. CL number and volume, T2 white matter (WM) lesion volume, gray matter fraction, and expanded disability status scale (EDSS) were measured. Results: At baseline, CLs were detected in 64.4% of RRMS and 74.2% of SPMS patients. During follow‐up, 132 new CLs were found in 44 RRMS patients (57.9%; 0.8 new CL/patient/yr) and 61 in 15 SPMS patients (48.4%; 1.0 new CL/patient/yr). Among these patients, only 31 also showed at least 1 new WM lesion. CL number and volume increases were higher in the 52 patients with a clinical worsening compared with those without ( p < 0.001). Baseline CL volume correlated with baseline EDSS ( r = 0.36, p < 0.001) and EDSS changes over time ( r = 0.51, p < 0.001). Baseline CL volume was an independent predictor of EDSS accumulation and GM volume change at follow‐up in both patient groups. In SPMS patients, baseline T2 WM lesion volume was another independent predictor of EDSS worsening. Interpretation: In relapse‐onset MS, CLs accumulate over time and are associated with disability progression. The quantification of CLs might represent an additional useful paraclinical tool to monitor MS evolution. ANN NEUROL 2010;67:376–383
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Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Peterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403 · cited 2×
“Immunopathologically, compared with WM lesions, CLs are characterized by modest damage to the blood-brain barrier(11) and a relative lack of T-cell and B-cell infiltration, microglia activation, and astrogliosis.(2,12) Considering the different immunopathological features of WM and GM lesions, mixed WM/GM lesions (typ…”
BackgroundFisniku, L. K., Brex, P. A., Altmann, D. R., Miszkiel, K. A., Benton, C. E., Lanyon, R., Thompson, A. J., & Miller, D. H. (2008) · Brain · doi:10.1093/brain/awm329 · Cited by 897
A longitudinal study of abnormalities on MRI and disability from multiple sclerosis
Brex, P. A., Ciccarelli, O., O'Riordan, J. I., Sailer, M., Thompson, A. J., & Miller, D. H. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011341 · Cited by 861
Kappos, L., Moeri, D., Radue, E. W., Schoetzau, A., Schweikert, K., Barkhof, F., Miller, D., Guttmann, C. R., Weiner, H. L., Gasperini, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)03053-0 · Cited by 499
Self-citationMRI in multiple sclerosis: current status and future prospects
Bakshi, R., Thompson, A. J., Rocca, M. A., Pelletier, D., Dousset, V., Barkhof, F., Inglese, M., Guttmann, C. R., Horsfield, M. A., & Filippi, M. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70137-6 · Cited by 348
Self-citationThe blood-brain barrier in cortical multiple sclerosis lesions
van Horssen, J., Brink, B. P., de Vries, H. E., van der Valk, P., & Bø, L. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318040b2de · Cited by 187
Cited by
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22366 · Cited by 9,802
Self-citationA Gradient of neuronal loss and meningeal inflammation in multiple sclerosis
Magliozzi, R., Howell, O. W., Reeves, C., Roncaroli, F., Nicholas, R., Serafini, B., Aloisi, F., & Reynolds, R. (2010) · Annals of Neurology · doi:10.1002/ana.22230 · Cited by 747
Association between pathological and MRI findings in multiple sclerosis
Filippi, M., Rocca, M. A., Barkhof, F., Brück, W., Chen, J. T., Comi, G., DeLuca, G., De Stefano, N., Erickson, B. J., Evangelou, N., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70003-0 · Cited by 486
Self-citationCortical lesion load associates with progression of disability in multiple sclerosis
Calabrese, M., Poretto, V., Favaretto, A., Alessio, S., Bernardi, V., Romualdi, C., Rinaldi, F., Perini, P., & Gallo, P. (2012) · Brain · doi:10.1093/brain/aws246 · Cited by 329
Self-citationCortical lesions in multiple sclerosis
Calabrese, M., Filippi, M., & Gallo, P. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.93 · Cited by 269
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Metadata
- Authors
- Calabrese, M., Rocca, M. A., Atzori, M., Mattisi, I., Favaretto, A., Perini, P., Gallo, P., & Filippi, M.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 67
- Issue
- 3
- Pages
- 376-383
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1591670091
- Cited by
- 186
- References
- 7
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- closed
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