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Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease
Open accessAbstract
Objective: To study the effect of apolipoprotein E ϵ4 status on biomarkers of neurodegeneration (atrophy on magnetic resonance imaging [MRI]), neuronal injury (cerebrospinal fluid [CSF] t‐tau), and brain Aβ amyloid load (CSF Aβ 1–42) in cognitively normal subjects (CN), amnestic subjects with mild cognitive impairment (aMCI), and patients with Alzheimer disease (AD). Methods: We included all 399 subjects (109 CN, 192 aMCI, 98 AD) from the Alzheimer's Disease Neuroimaging Initiative study with baseline CSF and MRI scans. Structural Abnormality Index (STAND) scores, which reflect the degree of AD‐like anatomic features on MRI, were computed for each subject. Results: A clear ϵ4 allele dose effect was seen on CSF Aβ 1–42 levels within each clinical group. In addition, the proportion of the variability in Aβ 1–42 levels explained by APOE ϵ4 dose was significantly greater than the proportion of the variability explained by clinical diagnosis. On the other hand, the proportion of the variability in CSF t‐tau and MRI atrophy explained by clinical diagnosis was greater than the proportion of the variability explained by APOE ϵ4 dose; however, this effect was only significant for STAND scores. Interpretation: Low CSF Aβ 1–42 (surrogate for Aβ amyloid load) is more closely linked to the presence of APOE ϵ4 than to clinical status. In contrast, MRI atrophy (surrogate for neurodegeneration) is closely linked with cognitive impairment, whereas its association with APOE ϵ4 is weaker. The data in this paper support a model of AD in which CSF Aβ 1–42 is the earliest of the 3 biomarkers examined to become abnormal in both APOE carriers and noncarriers. ANN NEUROL 2010;67:308–316
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“Studies showed that APOE4 carriers featured decreased cortical thickness and smaller hippocampal volume, and with an advanced mild cognitive impairment (MCI) age compared to non-carriers [462–464].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [462]
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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
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Self-citationThe Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods
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Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396
Self-citationApolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459
Biomarker Modeling of Alzheimer’s Disease
Jack, C. R., & Holtzman, D. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.12.003 · Cited by 1,002
Self-citationMolecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
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Metadata
- Authors
- Vemuri, P., Wiste, H. J., Weigand, S. D., Knopman, D. S., Shaw, L. M., Trojanowski, J. Q., Aisen, P. S., Weiner, M., Petersen, R. C., Jack, C. R., & Initiative, A. D. N.
- Affiliations
- Mayo Clinic (US)
- University of Pennsylvania (US)
- University of California San Diego (US)
- San Francisco VA Medical Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Corresponding author
- Jack, Clifford R.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 67
- Issue
- 3
- Pages
- 308-316
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC2886799
- OpenAlex
- W1484611135
- Cited by
- 195
- References
- 61
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 5 · 2018: 8 · 2017: 12 · 2016: 12 · 2015: 21 · 2014: 8 · 2013: 25 · 2012: 13
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01ag024904-10)
- National Institute on Aging (U01-AG-024904, R01AG011378, AG-11378, U19AG010483, R37AG011378)
- National Center for Research Resources (RR018898, C06RR018898)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- APOE ε4, Alzheimer's disease, amyloid-beta 42, cerebrospinal fluid biomarkers, tau protein, neurodegeneration, brain atrophy, mild cognitive impairment, amyloid load, neuronal injury
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Brain, DNA Mutational Analysis, Female, Genetic Markers, Genetic Testing, Genotype, Humans, Magnetic Resonance Imaging, Male, Peptide Fragments, Severity of Illness Index, Biomarkers, Amyloid beta-Peptides, Neurofibrillary Tangles, tau Proteins, Disease Progression, Gene Dosage, Genetic Predisposition to Disease, Apolipoprotein E4, Plaque, Amyloid
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