Cerebrospinal fluid β-amyloid1–42 and tau in control subjects at risk for Alzheimer’s disease: The effect of APOE ε4 allele
Abstract
Background Cerebrospinal fluid (CSF) measures of beta-amyloid(1-42) and tau are linked with the known neuropathology of Alzheimer's disease (AD). Numerous lines of evidence have also suggested that individuals with at least one APOE epsilon4 allele on chromosome 19 are at increased risk of developing AD. We tested these CSF markers in groups of subjects with AD and healthy older control subjects, using the absence or presence of the APOE epsilon4 allele as a predictive variable in the search for possible prognostic biomarkers of AD. Methods We assessed the levels of beta-amyloid(1-42) and total tau in the CSF of 292 subjects (142 control subjects and 150 subjects with mild-to-moderate AD), who were research participants at the National Institute of Mental Health. The group of control subjects was enriched with a high percentage of subjects with a positive family history of AD. All subjects underwent extensive global cognitive testing. Results When divided according to the absence or presence of the APOE epsilon4 allele, the control subjects with at least one epsilon4 allele had significantly lower CSF beta-amyloid(1-42) but not tau levels than control subjects without an APOE epsilon4 allele (p Conclusions The association of APOE epsilon4 allele and lower, more AD-like levels of CSF beta-amyloid(1-42) in older control subjects is consistent with previous studies showing possible neuroimaging and cognitive abnormalities with epsilon4 carriers and suggests that CSF beta-amyloid…
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In a large CSF study of cognitively normal middle age people, CSF Aβ42 was apoE4-dose dependently lower.
“In fact, in a large CSF study of cognitively normal middle age people, CSF Aβ42 was apoE4-dose dependently lower (Sunderland et al., 2004).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Sunderland et al., 2004
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- Authors
- Sunderland, T., Mirza, N., Putnam, K. T., Linker, G., Bhupali, D., Durham, R., Soares, H., Kimmel, L., Friedman, D., Bergeson, J., Csako, G., Levy, J. A., Bartko, J. J., & Cohen, R. M.
- Affiliations
- National Institutes of Health (US)
- National Institute of Mental Health (US)
- Pfizer (United States) (US)
- Corresponding author
- Sunderland, Trey
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 56
- Issue
- 9
- Pages
- 670-676
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2060492349
- Cited by
- 179
- References
- 5
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 12 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 18
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (Z01 MH00330-14)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- Alzheimer's disease, APOE ε4, cerebrospinal fluid, amyloid-beta 42, tau protein, biomarkers, genetic risk, family history (medicine), early detection, conversion to Alzheimer's disease, older adults
- MeSH terms
- Age Factors, Aged, Alleles, Alzheimer Disease, Apolipoproteins E, Demography, Enzyme-Linked Immunosorbent Assay, Female, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Peptide Fragments, Risk, Spinal Puncture, Chi-Square Distribution, Amyloid beta-Peptides, tau Proteins, Apolipoprotein E4
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