The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Autoantibodies to low‐density lipoprotein receptor–related protein 4 in myasthenia gravis
Abstract
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction, where acetylcholine receptor (AChR), muscle‐specific kinase (MuSK), and low‐density lipoprotein (LDL) receptor‐related protein 4 (Lrp4) are essential. About 80% and 0% to 10% of patients with generalized MG have autoantibodies to AChR and MuSK, respectively, but pathogenic factors are elusive in others. Here we show that a proportion of AChR antibody‐negative patients have autoantibodies to Lrp4. These antibodies inhibit binding of Lrp4 to its ligand and predominantly belong to the immunoglobulin G1 (IgG1) subclass, a complement activator. These findings together indicate the involvement of Lrp4 antibodies in the pathogenesis of AChR antibody‐negative MG. Ann Neurol 2011
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Cites
An adaptive coding model of neural function in prefrontal cortex
Duncan, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35097575 · Cited by 874
LRP4 serves as a coreceptor of Agrin
Zhang, B., Luo, S., Wang, Q., Suzuki, T., Xiong, W. C., & Mei, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.006 · Cited by 525
LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction
Weatherbee, S. D., Anderson, K. V., & Niswander, L. A. (2006) · Development · doi:10.1242/dev.02696 · Cited by 351
Cited by
Gilhus, N. E. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1602678 · Cited by 1,048
The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes
Marx, A., Pfister, F., Schalke, B., Saruhan-Direskeneli, G., Melms, A., & Ströbel, P. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.03.007 · Cited by 351
Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis
Pevzner, A., Schoser, B., Peters, K., Cosma, N.-C., Karakatsani, A., Schalke, B., Melms, A., & Kröger, S. (2012) · Journal of Neurology · doi:10.1007/s00415-011-6194-7 · Cited by 342
Koźmiński, P., Halik, P. K., Chesori, R., & Gniazdowska, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103483 · Cited by 326
Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4
Gomez, A. M., Froemke, R. C., & Burden, S. J. (2014) · eLife · doi:10.7554/elife.04287 · Cited by 47
Metadata
- Authors
- Higuchi, O., Hamuro, J., Motomura, M., & Yamanashi, Y.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2011-02
- Volume
- 69
- Issue
- 2
- Pages
- 418-422
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2102593255
- Cited by
- 535
- References
- 3
- FWCI
- 15.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Higuchi, O., Hamuro, J., Motomura, M., & Yamanashi, Y. (2011). Autoantibodies to low‐density lipoprotein receptor–related protein 4 in myasthenia gravis. Annals of Neurology. https://doi.org/10.1002/ana.22312
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