Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers
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Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases. In this paper, we take an overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy. In addition, the issue of the potential benefits of methotrexate in the development of neurological disorders in Alzheimer’s disease or myasthenia gravis will be discussed.
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The observation of methotrexate-induced G1 arrest is consistent with its reported inhibition of DNA synthesis during S phase.
“This observation is consistent with its reported inhibition of DNA synthesis during S phase48.”
From A statistical framework for high-content phenotypic profiling using cellular feature distributions (2022) · cites this paper as [48]
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References 302 · Cited by 326
Research works printed but not linked: 1
- [242]Davis T.P. Enna S.J. Lecount L. Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders 1st ed. Elsevier INC Amsterdam, The Netherlands 2014
- Authors
- Koźmiński, P., Halik, P. K., Chesori, R., & Gniazdowska, E.
- Affiliations
- Instytut Chemii i Techniki Jądrowej (PL)
- Corresponding author
- Koźmiński, Przemysław
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-05-14
- Volume
- 21
- Issue
- 10
- Pages
- 3483
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7279024
- OpenAlex
- W3024378081
- Cited by
- 326
- References
- 302
- Citations by year
- 2026: 47 · 2025: 63 · 2024: 59 · 2023: 60 · 2022: 62 · 2021: 31 · 2020: 2 · 2019: 1
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institute of Nuclear Chemistry and Technology, Warsaw, Poland (This research was funded by statutory activity)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- methotrexate, folic acid analogues, immunosuppressants, chemotherapy, autoimmune disease, neurological disorders, Alzheimer's disease, myasthenia gravis, mechanism of action, combination therapy
- MeSH terms
- Autoimmune Diseases, Pharmaceutical Preparations, Folic Acid, Humans, Methotrexate, Neoplasms, Nervous System Diseases
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