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Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: A multicenter study

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Postuma, Ronald B., Iranzo, Alex, Hogl, Birgit, Arnulf, Isabelle, Ferini‐Strambi, Luigi, Manni, Raffaele, Miyamoto, Tomoyuki, Oertel, Wolfgang, Dauvilliers, Yves, Ju, Yo‐El, Puligheddu, Monica, Sonka, Karel, Pelletier, Amelie, Santamaria, Juan, Frauscher, Birgit, Leu‐Semenescu, Smaranda, Zucconi, Marco, Terzaghi, Michele, Miyamoto, Masayuki, Unger, Marcus M., Carlander, Bertrand, Fantini, Maria‐Livia, Montplaisir, Jacques Y.·2015·Annals of Neurology

Abstract

Objective: To assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). Methods: Twelve centers administered a detailed questionnaire assessing risk factors for neurodegenerative synucleinopathy to patients with idiopathic RBD. Variables included demographics, lifestyle factors, pesticide exposures, occupation, comorbid conditions, medication use, family history, and autonomic/motor symptoms. After 4 years of follow‐up, patients were assessed for dementia or parkinsonism. Disease risk was assessed with Kaplan–Meier analysis, and epidemiologic variables were compared between convertors and those still idiopathic using logistic regression. Results: Of 305 patients, follow‐up information was available for 279, of whom 93 (33.3%) developed defined neurodegenerative disease. Disease risk was 25% at 3 years and 41% after 5 years. Patients who converted were older (difference = 4.5 years, p < 0.001), with similar sex distribution. Neither caffeine, smoking, nor alcohol exposure predicted conversion. Although occupation was similar between groups, those who converted had a lower likelihood of pesticide exposure (occupational insecticide = 2.3% vs 9.0%). Convertors were more likely to report family history of dementia (odds ratio [OR] = 2.09), without significant differences in Parkinson disease or sleep disorders. Medication exposures and medical history were similar between groups. Autonomic and motor symptoms were more common among those who converted. Risk factors for primary dementia and parkinsonism were generally similar, except for a notably higher clonazepam use in dementia convertors (OR = 2.6). Interpretation: Patients with idiopathic RBD are at very high risk of neurodegenerative synucleinopathy. Risk factor profiles between convertors and nonconvertors have both important commonalities and differences. Ann Neurol 2015;77:830–839

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Metadata

Authors
Postuma, R. B., Iranzo, A., Hogl, B., Arnulf, I., Ferini‐Strambi, L., Manni, R., Miyamoto, T., Oertel, W., Dauvilliers, Y., Ju, Y., Puligheddu, M., Sonka, K., Pelletier, A., Santamaria, J., Frauscher, B., Leu‐Semenescu, S., Zucconi, M., Terzaghi, M., Miyamoto, M., Unger, M. M., Carlander, B., Fantini, M., & Montplaisir, J. Y.
Venue
Annals of Neurology
Publisher
Wiley
Published
2015-03-13
Volume
77
Issue
5
Pages
830-839
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2162234212
Cited by
291
References
4
FWCI
25.71
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: A multicenter study. https://app.cochat.ai/papers/10.1002/ana.24385
The paper
Postuma, R. B., Iranzo, A., Hogl, B., Arnulf, I., Ferini‐Strambi, L., Manni, R., Miyamoto, T., Oertel, W., Dauvilliers, Y., Ju, Y., Puligheddu, M., Sonka, K., Pelletier, A., Santamaria, J., Frauscher, B., Leu‐Semenescu, S., Zucconi, M., Terzaghi, M., Miyamoto, M., . . . Montplaisir, J. Y. (2015). Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: A multicenter study. Annals of Neurology. https://doi.org/10.1002/ana.24385

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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