Neurodegenerative Disorder Risk in Idiopathic REM Sleep Behavior Disorder: Study in 174 Patients
Open accessAbstract
OBJECTIVE: To estimate the risk for developing a defined neurodegenerative syndrome in a large cohort of idiopathic REM sleep behavior disorder (IRBD) patients with long follow-up. METHODS: Using the Kaplan-Meier method, we estimated the disease-free survival rate from defined neurodegenerative syndromes in all the consecutive IRBD patients diagnosed and followed-up in our tertiary referal sleep center between November 1991 and July 2013. RESULTS: The cohort comprises 174 patients with a median age at diagnosis of IRBD of 69 years and a median follow-up of four years. The risk of a defined neurodegenerative syndrome from the time of IRBD diagnosis was 33.1% at five years, 75.7% at ten years, and 90.9% at 14 years. The median conversion time was 7.5 years. Emerging diagnoses (37.4%) were dementia with Lewy bodies (DLB) in 29 subjects, Parkinson disease (PD) in 22, multiple system atrophy (MSA) in two, and mild cognitive impairment (MCI) in 12. In six cases, in whom postmortem was performed, neuropathological examination disclosed neuronal loss and widespread Lewy-type pathology in the brain in each case. CONCLUSIONS: In a large IRBD cohort diagnosed in a tertiary referal sleep center, prolonged follow-up indicated that the majority of patients are eventually diagnosed with the synucleinopathies PD, DLB and less frequently MSA. IRBD represented the prodromal period of these conditions. Our findings in IRBD have important implications in clinical practice, in the investigation of the early pathological events occurring in the synucleinopathies, and for the design of interventions with potential disease-modifying agents.
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More than 80% of people with RBD are later diagnosed with PD or dementia.
“more than 80% of people with RBD are later diagnosed with PD or dementia274,275”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [274]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,232 · see citing works
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158 · see citing works
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Siegel, L. J., & Fletcher‐Janzen, E. (2008) · Wiley eBooks · doi:10.1002/9780470373699.speced0655 · Cited by 8,468 · see citing works
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,105 · see citing works
Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium
McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J.-P., Weintraub, D., Aarsland, D., Galvin, J., Attems, J., Ballard, C. G., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004058 · Cited by 4,476 · see citing works
Self-citationSecond consensus statement on the diagnosis of multiple system atrophy
Gilman, S., Wenning, G. K., Low, P. A., Brooks, D. J., Mathias, C. J., Trojanowski, J. Q., Wood, N. W., Colosimo, C., Dürr, A., Fowler, C. J., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000324625.00404.15 · Cited by 3,140 · see citing works
Schenck, C. H., Bundlie, S. R., & Mahowald, M. W. (1996) · Neurology · doi:10.1212/wnl.46.2.388 · Cited by 1,083 · see citing works
Iranzo, Á., Molinuevo, J. L., Santamaría, J., Serradell, M., Martı́, M. J., Valldeoriola, F., & Tolosa, E. S. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70476-8 · Cited by 950 · see citing works
Self-citationSchenck, C. H., Boeve, B. F., & Mahowald, M. W. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2012.10.009 · Cited by 814 · see citing works
Parkinson’s Disease and Movement Disorders
Tn, M., & Bhattacharyya, K. (2005) · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · doi:10.5005/jp/books/10587 · Cited by 804 · see citing works
Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder
Postuma, R. B., Gagnon, J., Vendette, M., Fantini, M. L., Massicotte-Marquez, J., & Montplaisir, J. Y. (2008) · Neurology · doi:10.1212/01.wnl.0000340980.19702.6e · Cited by 767 · see citing works
McKeith, I. G. (2004) · Europe PMC (PubMed Central) · Cited by 756 · see citing works
Iranzo, Á., Tolosa, E. S., Gelpí, E., Molinuevo, J. L., Valldeoriola, F., Serradell, M., Sánchez‐Valle, R., Vilaseca, I., Lomeña, F., Vilas, D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70056-5 · Cited by 724 · see citing works
Self-citationBoeve, B. F. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05115.x · Cited by 641 · see citing works
Cognitive impairment in incident, untreated Parkinson disease: The Norwegian ParkWest Study
Aarsland, D., Brønnick, K., Larsen, J. P., Tysnes, O. B., & Alves, G. (2009) · Neurology · doi:10.1212/01.wnl.0000338632.00552.cb · Cited by 625 · see citing works
McKeith, I. G., Mintzer, J. E., Aarsland, D., Burn, D. J., Chiu, H. F. K., Cohen‐Mansfield, J., Dickson, D. W., Dubois, B., Duda, J. E., Feldman, H., et al. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00619-7 · Cited by 618 · see citing works
Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease
Postuma, R. B., Aarsland, D., Barone, P., Burn, D. J., Hawkes, C. H., Oertel, W. H., & Ziemssen, T. (2012) · Movement Disorders · doi:10.1002/mds.24996 · Cited by 613 · see citing works
Preedy, V. R., & WATSON, R. R. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5543 · Cited by 554 · see citing works
Wenning, G. K., Colosimo, C., Geser, F., & Poewe, W. H. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00662-8 · Cited by 467 · see citing works
Iranzo, Á., Lomeña, F., Stockner, H., Valldeoriola, F., Vilaseca, I., Salamero, M., Molinuevo, J. L., Serradell, M., Duch, J., Pavı́a, J., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70216-7 · Cited by 390 · see citing works
Self-citationIranzo, Á., Valldeoriola, F., Lomeña, F., Molinuevo, J., Serradell, M., Salamero, M., Cot, A., Ros, D., Pavía, J., Santamaria, J., et al. (2011) · Lancet Neurology · doi:10.1016/s1474-4422(11)70152-1 · Cited by 319 · see citing works
Self-citationPrognosis of Mild Cognitive Impairment in Early Parkinson Disease: The Norwegian ParkWest Study
Pedersen, K. F., Larsen, J. P., Tysnes, O.-B., & Alves, G. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2110 · Cited by 315 · see citing works
Iranzo, Á., Santamaría, J., & Tolosa, E. S. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.11.003 · Cited by 292 · see citing works
Self-citationPrevalence and impact of vascular and Alzheimer pathologies in Lewy body disease
Jellinger, K. A., & Attems, J. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0347-5 · Cited by 266 · see citing works
Postuma, R. B., Gagnon, J., Vendette, M., & Montplaisir, J. Y. (2009) · Brain · doi:10.1093/brain/awp244 · Cited by 261 · see citing works
Diagnosis and the premotor phase of Parkinson disease
TOLOSA, E. S., Gaig, C., Santamaría, J., & Compta, Y. (2009) · Neurology · doi:10.1212/wnl.0b013e318198db11 · Cited by 257 · see citing works
Self-citationPostuma, R. B., Gagnon, J., Vendette, M., Desjardins, C., & Montplaisir, J. Y. (2010) · Annals of Neurology · doi:10.1002/ana.22282 · Cited by 242 · see citing works
REM sleep behavior disorder: motor manifestations and pathophysiology
Arnulf, I. (2012) · Movement Disorders · doi:10.1002/mds.24957 · Cited by 231 · see citing works
Martí-Massó, J. F., & Martínez, J. R. (2000) · PubMed · Cited by 231 · see citing works
Scherfler, C., Frauscher, B., Schocke, M. F. H., Iranzo, Á., Gschliesser, V., Seppi, K., Santamaría, J., TOLOSA, E. S., Högl, B., Poewe, W. H., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22245 · Cited by 220 · see citing works
Self-citationMolano, J. R. V., Boeve, B. F., Ferman, T. J., Smith, G. E., Parisi, J. E., Dickson, D. W., Knopman, D. S., Graff‐Radford, N. R., Geda, Y. E., Lucas, J. A., et al. (2009) · Brain · doi:10.1093/brain/awp280 · Cited by 205 · see citing works
Boot, B. P., Boeve, B. F., Roberts, R. O., Ferman, T. J., Geda, Y. E., Pankratz, V. S., Ivnik, R. J., Smith, G. E., McDade, E., Christianson, T. J. H., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22655 · Cited by 197 · see citing works
Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience
Kovacs, G. G., Alafuzoff, I., Al-Sarraj, S., Arzberger, T., Bogdanovic, N., Capellari, S., Ferrer, I., Gelpi, E., Kövari, V., Kretzschmar, H., et al. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000161560 · Cited by 186 · see citing works
Self-citationMorales, J. M., Bermejo, F., Benito‐León, J., Navarro, J. R., Trincado, R., S, R. G., Vega, S., & NEDICES Study Group (2004) · Public Health · doi:10.1016/j.puhe.2003.10.007 · Cited by 110 · see citing works
Wenning, G. K., & Braune, S. (2001) · CNS Drugs · doi:10.2165/00023210-200115110-00003 · Cited by 102 · see citing works
Longitudinal assessment of olfactory function in idiopathic REM sleep behavior disorder
Iranzo, Á., Serradell, M., Vilaseca, I., Valldeoriola, F., Salamero, M., Molina, C., Santamaría, J., & TOLOSA, E. S. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.02.009 · Cited by 74 · see citing works
Self-citationEpidemiology of movement disorders
Schrag, A. (2004) · UCL Discovery (University College London) · Cited by 18 · see citing works
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Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium
McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J.-P., Weintraub, D., Aarsland, D., Galvin, J., Attems, J., Ballard, C. G., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004058 · Cited by 4,476 · see citing works
Self-citationObeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859 · see citing works
Self-citationRhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
New evidence on the management of Lewy body dementia
Taylor, J.-P., McKeith, I. G., Burn, D. J., Boeve, B. F., Weintraub, D., Bamford, C., Allan, L. M., Thomas, A. J., & O'Brien, J. T. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30153-x · Cited by 347 · see citing works
Wilson, S., Anderson, K., Baldwin, D., Dijk, D.-J., Espie, A., Espie, C., Gringras, P., Krystal, A., Nutt, D., Selsick, H., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119855343 · Cited by 312 · see citing works
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies
Poggiolini, I., Gupta, V., Lawton, M., Lee, S., El-Turabi, A., Querejeta-Coma, A., Trenkwalder, C., Sixel-Döring, F., Foubert-Samier, A., Pavy-Le Traon, A., et al. (2022) · Brain · doi:10.1093/brain/awab431 · Cited by 191 · see citing works
Neurodegenerative Disorders and Sleep
Malhotra, R. K. (2018) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2017.09.006 · Cited by 127 · see citing works
Bedard, M.-A., Aghourian, M., Legault-Denis, C., Postuma, R. B., Soucy, J.-P., Gagnon, J.-F., Pelletier, A., & Montplaisir, J. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2018.12.020 · Cited by 123 · see citing works
Rusz, J., Hlavnička, J., Tykalová, T., Bušková, J., Ulmanová, O., Růžička, E., & Šonka, K. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2015.07.030 · Cited by 94 · see citing works
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58 · see citing works
“As many as 90% of individuals diagnosed with REM sleep behaviour disorder will go on to develop a neurodegenerative disease associated with α-synuclein aggregation (Boeve et al., 2001; Iranzo et al., 2014).”
BackgroundFeinsilver, S. H., & Hernandez, A. B. (2017) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2017.06.009 · Cited by 44 · see citing works
Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic
Kunz, D., Stotz, S., & Bes, F. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12759 · Cited by 42 · see citing works
Timeline of Rapid Eye Movement Sleep Behavior Disorder in Overt <scp>Alpha‐Synucleinopathies</scp>
Stang, C. D., Mullan, A. F., Hajeb, M., Camerucci, E., Turcano, P., Martin, P., Mielke, M. M., Josephs, K. A., Bower, J. H., St Louis, E. K., et al. (2021) · Annals of Neurology · doi:10.1002/ana.25952 · Cited by 29 · see citing works
Sleep and Circadian Rhythm Disorders in Parkinson’s Disease
Gros, P., & Videnovic, A. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0079-y · Cited by 29 · see citing works
Sleep in Neurodegenerative Disorders
Malkani, R., & Attarian, H. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-015-0016-x · Cited by 12 · see citing works
- Authors
- Iranzo, A., Fernández-Arcos, A., Tolosa, E., Serradell, M., Molinuevo, J. L., Valldeoriola, F., Gelpi, E., Vilaseca, I., Sánchez-Valle, R., Lladó, A., Gaig, C., & Santamaría, J.
- Affiliations
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-02-26
- Volume
- 9
- Issue
- 2
- Pages
- e89741
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3935943
- OpenAlex
- W2023130608
- Cited by
- 548
- References
- 41
- Citations by year
- 2026: 41 · 2025: 48 · 2024: 39 · 2023: 41 · 2022: 45 · 2021: 44 · 2020: 52 · 2019: 50 · 2018: 52 · 2017: 63 · 2016: 40 · 2015: 28 · 2014: 5
- FWCI
- 29.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- idiopathic REM sleep behavior disorder, neurodegenerative disease risk, synucleinopathies, dementia with Lewy bodies, Parkinson's disease, multiple system atrophy, mild cognitive impairment, prodromal period, Lewy body pathology, disease-free survival
- MeSH terms
- Aged, Humans, Middle Aged, Cohort Studies, Disease-Free Survival, Neurodegenerative Diseases, REM Sleep Behavior Disorder, Kaplan-Meier Estimate
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