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Cited by 89Autoimmune Neurological Disorders and TreatmentsSystemic Lupus Erythematosus ResearchPeripheral Neuropathies and Disorders

The brain as immunoprecipitator of serum autoantibodies against N‐Methyl‐D‐aspartate receptor subunit NR1

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Castillo‐Gomez, Esther, Kästner, Anne, Steiner, Johann, Schneider, Anja, Hettling, Bilke, Poggi, Giulia, Ostehr, Kristin, Uhr, Manfred +10 more·2016·Annals of Neurology
DOI 10.1002/ana.24545
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Abstract

Autoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) are highly seroprevalent in health and disease. Symptomatic relevance may arise upon compromised blood-brain barrier (BBB). However, it remained unknown whether circulating NMDAR1 AB appear in the cerebrospinal fluid (CSF). Of n = 271 subjects with CSF-serum pairs, 26 were NMDAR1 AB seropositive, but only 1 was CSF positive. Contrariwise, tetanus AB (non-brain-binding) were present in serum and CSF of all subjects, with CSF levels higher upon BBB dysfunction. Translational mouse experiments proved the hypothesis that the brain acts as an 'immunoprecipitator'; simultaneous injection of NMDAR1 AB and the non-brain-binding green fluorescent protein AB resulted in high detectability of the former in brain and the latter in CSF.

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  • Transgenic mice lacking Apoe develop an early BBB breakdown.

    “Transgenic mice lacking Apoe also develop an early BBB breakdown (60, 99, 147, 187, 226, 233, 406, 426, 437, 554), indicating that APOE is essential for maintaining BBB integrity.”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [99]

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Authors
Castillo‐Gomez, E., Kästner, A., Steiner, J., Schneider, A., Hettling, B., Poggi, G., Ostehr, K., Uhr, M., Asif, A. R., Matzke, M., Schmidt, U., Pfander, V., Hammer, C., Schulz, T. F., Binder, L., Stöcker, W., Weber, F., & Ehrenreich, H.
Affiliations
  • Department of Clinical Neuroscience Max Planck Institute of Experimental Medicine Göttingen
  • Max Planck Institute of Experimental Medicine (DE)
  • Department of Psychiatry University of Magdeburg Magdeburg
  • German Center for Neurodegenerative Diseases (DE)
  • Otto-von-Guericke-Universität Magdeburg (DE)
  • Max Planck Institute of Psychiatry (DE)
  • Universitätsmedizin Göttingen (DE)
  • Medizinische Hochschule Hannover (DE)
  • Institute for Experimental Immunology, (affiliated with Euroimmun, Lübeck) Göttingen Germany
  • Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 (DE)
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
2015-12-02
Volume
79
Issue
1
Pages
144-151
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.24545
OpenAlex
W2253891573
Cited by
89
References
4
Citations by year
2026: 3 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 12 · 2019: 10 · 2018: 10 · 2017: 15 · 2016: 4 · 2014: 1
FWCI
6.82
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
  • Max Planck Digital Library (submittedVersion)
  • DZNE Pub (submittedVersion)
  • GRO (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (SFB TRR 43, TRR-43)
  • Max-Planck-Gesellschaft
Topics
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
autoantibodies, cerebrospinal fluid, blood-brain barrier, immunoprecipitation, mouse model
MeSH terms
Adult, Animals, Autoantibodies, Blood-Brain Barrier, Brain, Female, Humans, Male, Mice, Inbred C57BL, Middle Aged, Multiple Sclerosis, Seroepidemiologic Studies, Receptors, N-Methyl-D-Aspartate, Mice

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