Cited by 908Cancer Treatment and PharmacologyChemotherapy-related skin toxicityPeripheral Neuropathies and Disorders

Chemotherapy-induced peripheral neuropathy: a current review

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Staff, Nathan P., Grisold, Anna, Grisold, Wolfgang, Windebank, Anthony J.·2017·Annals of Neurology

Abstract

Chemotherapy‐induced peripheral neuropathy (CIPN) is a common dose‐limiting side effect experienced by patients receiving treatment for cancer. Approximately 30 to 40% of patients treated with neurotoxic chemotherapy will develop CIPN, and there is considerable variability in its severity between patients. It is often sensory‐predominant with pain and can lead to long‐term morbidity in survivors. The prevalence and burden of CIPN late effects will likely increase as cancer survival rates continue to improve. In this review, we discuss the approach to peripheral neuropathy in patients with cancer and address the clinical phenotypes and pathomechanisms of specific neurotoxic chemotherapeutic agents. Ann Neurol 2017;81:772–781

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  1. [38]Pachman DR Qin R Seisler DK Clinical course of oxaliplatin-induced neuropathy: results from the randomized phase III trial N08CB (Alliance) Journal of Clinical Oncology 2015 33 30 3416 22 26282635 PMC4606060

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Authors
Staff, N. P., Grisold, A., Grisold, W., & Windebank, A. J.
Affiliations
  • Mayo Clinic (US)
  • Medical University of Vienna (AT)
  • Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA (AT)
Corresponding author
Staff, Nathan P.
Venue
Annals of Neurology
Publisher
Wiley
Published
2017-06
Volume
81
Issue
6
Pages
772-781
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2613929012
Cited by
908
References
115
Citations by year
2026: 121 · 2025: 136 · 2024: 126 · 2023: 115 · 2022: 119 · 2021: 107 · 2020: 86 · 2019: 62 · 2018: 23 · 2017: 11 · 2013: 1
FWCI
5.22
Type
journal article
Language
en
Open access
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (K08 CA 169443)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
  • Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
chemotherapy-induced peripheral neuropathy, neurotoxic chemotherapy, cancer survivors, sensory neuropathy, neuropathic pain, pathogenesis, clinical phenotype, late effects of cancer treatment, dose-limiting toxicity
MeSH terms
Antineoplastic Agents, Humans, Neoplasms, Peripheral Nervous System Diseases, Neurotoxicity Syndromes

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