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Penicillin‐induced epileptiform activity in the hippocampal in vitro preparation
Abstract
An in vitro preparation has been developed in which epileptogenesis in mammalian central nervous system tissue may be studied. Addition of sodium penicillin to the medium bathing slices of guinea pig hippocampus induced epileptiform activity similar to that seen in hippocampal penicillin foci in vivo. Epileptiform events were recorded as synchronous field potentials and correlated cellular bursts that ocurred spontaneously and could be triggered by orthodromic stimulation. Intracellular recordings revealed that bursts were generated from large depolarization shifts in some neurons, while in others, burst discharges had little underlying baseline depolarization. This finding, and the presence of fast prepotentials in penicillin‐treated preparations, suggested the involvement of dendritic activity in generation of epileptiform discharges.
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Cited by
NMDA-dependent modulation of CA1 local circuit inhibition
Grunze, H., Rainnie, D., Hasselmo, M., Barkai, E., Hearn, E., McCarley, R., & Greene, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02034.1996 · Cited by 467
Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity
Schwartzkroin, P. A., & Prince, D. A. (1980) · Brain Research · doi:10.1016/0006-8993(80)90119-5 · Cited by 314
Self-citationTraub, R. D., Schmitz, D., Jefferys, J. G. R., & Draguhn, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00755-6 · Cited by 286
Evidence for modulation of GABAergic neurotransmission by nicotine
Freun, R. K., Jungschaffer, D. A., Collins, A. C., & Wehner, J. M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90160-6 · Cited by 49
Metadata
- Authors
- Schwartzkroin, P. A., & Prince, D. A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1977-05
- Volume
- 1
- Issue
- 5
- Pages
- 463-469
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2078177672
- Cited by
- 229
- References
- 0
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schwartzkroin, P. A., & Prince, D. A. (1977). Penicillin‐induced epileptiform activity in the hippocampal in vitro preparation. Annals of Neurology. https://doi.org/10.1002/ana.410010510
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