Evidence for modulation of GABAergic neurotransmission by nicotine
Abstract
Bath-application of nicotine (800 microM) to mouse hippocampal slices resulted in an increase in the amplitude of the population spike and the appearance of multiple population spikes in the CA1 pyramidal cell layer. Similar effects were observed after perfusion of the GABAA antagonist bicuculline methiodide (2 microM) and the glutamate decarboxylase inhibitor L-C-allylglycine (4 mM). These apparently excitatory effects of nicotine (800 microM) could be reversed by bath-application of gamma-aminobutyric acid (GABA; 400 microM), as well as by the GABA uptake inhibitor nipecotic acid (5 mM) and the benzodiazepine flurazepam (4 microM). Nicotine did not alter binding of [3H]GABA or [3H]flunitrazepam to whole brain plasma membranes. The results are consistent with the hypothesis that the electrophysiological effects of nicotine on CA1 pyramidal cell excitability is mediated by disruption of GABAergic transmission.
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A role for ACh in regulation of hippocampal excitability through presynaptic release of glutamate and GABA has been well-characterized.
“and a role for ACh in regulation of hippocampal excitability through presynaptic release of glutamate and GABA has also been well-characterized (Alkondon et al., 1997; Freund et al., 1988; Radcliffe et al., 1999).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Freund et al., 1988
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References 34 · Cited by 49
- Authors
- Freun, R. K., Jungschaffer, D. A., Collins, A. C., & Wehner, J. M.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Freun, Ronald K.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1988-06
- Volume
- 453
- Issue
- 1-2
- Pages
- 215-220
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1994029890
- Cited by
- 49
- References
- 34
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 2 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA-07043)
- National Center for Research Resources (RR-07013-20, RR07013-19)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, GABAergic neurotransmission, hippocampus, CA1 pyramidal neurons, population spike, GABAA receptor, GABA uptake, GABAergic inhibition, flurazepam, nipecotic acid, bicuculline methiodide
- MeSH terms
- Action Potentials, Allylglycine, Animals, Bicuculline, Brain Chemistry, Female, Flunitrazepam, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Hippocampus, Mice, Inbred DBA, Nicotine, Receptors, GABA-A, Mice, In Vitro Techniques
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