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Cited by 376

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Cerebral metabolism and atrophy in huntington's disease determined by 18FDG and computed tomographic scan

Kuhl, David E., Phelps, Michael E., Markham, Charles H., Metter, E. Jeffrey, Riege, Walter H., Winter, James·1982·Annals of Neurology
DOI 10.1002/ana.410120504
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Abstract

Patterns of local cerebral glucose utilization were measured with positron emission computed tomography using the 18 F‐fluorodeoxyglucose method in 13 patients with Huntington's disease (HD), 15 subjects at risk for HD, and 40 normal control subjects. These data were compared with computed tomographic measures of cerebral atrophy, with age, and with duration and severity of symptoms. The results indicate that in HD there is a characteristic decrease in glucose utilization in the caudate and putamen and that this local hypometabolism appears early and precedes bulk tissue loss. In contrast to patients with senile dementia, in these HD patients glucose utilization typically was normal throughout the rest of the brain, regardless of the severity of symptoms and despite apparent shrinkage of brain tissue. Our results suggest the possibility that the caudate may be hypometabolic in some asymptomatic subjects who are potential carriers of the autosomal dominant gene for HD.

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Crossref · 10.1002/ana.410120504

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2 of 2 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 44

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Metadata

Authors
Kuhl, D. E., Phelps, M. E., Markham, C. H., Metter, E. J., Riege, W. H., & Winter, J.
Venue
Annals of Neurology
Publisher
Wiley
Published
1982-11
Volume
12
Issue
5
Pages
425-434
ISSN
  • 0364-5134
  • 1531-8249
DOI
10.1002/ana.410120504
Cited by
376
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8011 d)

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