Cited by 393Dementia and Cognitive Impairment ResearchFunctional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

Decreases in regional cerebral blood flow with normal aging

Martin, Andrew J., Friston, Karl J., Colebatch, James G., Frackowiak, Richard S. J.·1991·Journal of Cerebral Blood Flow & Metabolism

Abstract

Positron emission tomographic (PET) images of regional cerebral blood flow (rCBF) from 30 normal, resting volunteers aged 30 to 85 years were analysed to identify areas where rCBF fell with age. Images were anatomically normalised, and a pixel-by-pixel linear regression was performed to remove differences in global CBF between subjects. Pixels at which rCBF then showed a significant (p less than 0.01) negative correlation with age were identified. They were displayed as a statistical parametric map (SPM) of correlations. We demonstrate an age-related decrease in adjusted rCBF in the cingulate, parahippocampal, superior temporal, medial frontal, and posterior parietal cortices bilaterally, and in the left insular and left posterior prefrontal cortices (omnibus significance, chi 2 = 2,291, p less than 0.0001, df = 1). Decreases in rCBF suggest a regionally specific loss of cerebral function with age. The affected areas were all limbic, or association, cortices. Therefore, these decreases may constitute the cerebral substrate of the cognitive changes that occur during normal aging.

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Crossref · 10.1038/jcbfm.1991.121

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Authors
Martin, A. J., Friston, K. J., Colebatch, J. G., & Frackowiak, R. S. J.
Affiliations
  • St Bartholomew's Hospital (GB)
  • Hammersmith Hospital (GB)
Venue
Journal of Cerebral Blood Flow & Metabolism
Published
1991-07
Volume
11
Issue
4
Pages
684-689
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
OpenAlex
W2089390439
Cited by
393
References
28
Citations by year
2026: 3 · 2025: 3 · 2024: 7 · 2023: 13 · 2022: 7 · 2021: 13 · 2020: 8 · 2019: 21 · 2018: 19 · 2017: 9 · 2016: 17 · 2015: 14 · 2014: 4 · 2013: 12 · 2012: 10
FWCI
7.85
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
regional cerebral blood flow, normal aging, age-related decline, cingulate cortex, parahippocampal cortex, superior temporal cortex, medial frontal cortex, posterior parietal cortex, insula, limbic cortex, association cortex, cognitive aging
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Blood Flow Velocity, Cerebrovascular Circulation, Female, Frontal Lobe, Gyrus Cinguli, Hippocampus, Humans, Male, Middle Aged, Parietal Lobe, Temporal Lobe, Tomography, Emission-Computed

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