The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Antispasticity drugs: Mechanisms of action
Abstract
Several different drugs are now used, or are potentially useful, to treat patients with spasticity. Although these compounds vary in their actions on spinal neurons and reflex arcs, it is possible to formulate reasonable hypotheses regarding their modes of action. The benzodiazepines bind to specific benzodiazepine receptors linked to classic γ‐aminobutyric acid (GABA) receptors located on the terminals of primary afferent fibers. This binding results in an increased affinity of the GABA receptor for the amino acid, an augmented flux of chloride ions across the terminal membrane, and an increase in the amount of presynaptic inhibition. Baclofen activates GABA B receptors putatively located on the same terminals. Activation of these receptors retards the influx of calcium ions into the terminals, thereby reducing the evoked release of excitatory amino acids and possibly other transmitters. Progabide and its metabolites act on both classic and GABA B receptors. Glycine works on specific inhibitory receptors located on spinal interneurons and motoneurons. The phenothiazines act on the brainstem to alter the function of fusimotor fibers. Phenytoin and carbamazepine reduce the afferent output of muscle spindles. Dantrolene diminishes the activation of the contractile process in muscle fibers by reducing the release of calcium ions from the sarcoplasmic reticulum. This review summarizes the data supporting these concepts.
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Cites
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Feldman, R. G., Young, R. R., & Koella, W. P. (1980) · Medical Entomology and Zoology · Cited by 1,121
Mammalian Muscle Receptors and Their Central Actions
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The Effect of DOPA on the Spinal Cord. 1. Influence on Transmission from Primary Aflerents
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Cited by
Addolorato, G., Leggio, L., Ferrulli, A., Cardone, S., Vonghia, L., Mirijello, A., Abenavoli, L., D'Angelo, C., Caputo, F., Zambon, A., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61814-5 · Cited by 685
Addolorato, G. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.5.504 · Cited by 481
γ-Aminobutyric acid (GABA) signalling in plants
Ramesh, S. A., Tyerman, S. D., Gilliham, M., & Xu, B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2415-7 · Cited by 313
Baclofen in the Treatment of Alcohol Withdrawal Syndrome: A Comparative Study vs Diazepam
Addolorato, G., Leggio, L., Abenavoli, L., Agabio, R., Caputo, F., Capristo, E., Colombo, G., Gessa, G. L., & Gasbarrini, G. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.08.042 · Cited by 203
Drugs Used to Treat Spasticity
Kita, M., & Goodkin, D. E. (2000) · Drugs · doi:10.2165/00003495-200059030-00006 · Cited by 172
Metadata
- Authors
- Davidoff, R. A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1985-02
- Volume
- 17
- Issue
- 2
- Pages
- 107-116
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2091076275
- Cited by
- 340
- References
- 51
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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