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Cited by 561

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

Open access
Study, R E, Barker, J L·1981·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.78.11.7180
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Abstract

Diazepam and (--)-pentobarbital each potentiate the increase in chloride ion conductance produced by gamma-aminobutyric acid (GABA) i voltage-clamped mouse spinal neurons grown in culture. Fluctuation analysis was used to compare the properties of elementary ion-channel events underlying the chloride conductance produced by GABA alone and during potentiation by the two drugs. Neither drug altered the conductance of an open ion channel, but both drugs affected the kinetics of channel activity. Diazepam increased the frequency of channel openings and either did not affect or slightly increased the average open-channel lifetime, whereas (--)-pentobarbital decreased the frequency of channel openings and increased average open-channel lifetime. These changes in the kinetics of GABA-activated ion channels can quantitatively account for the potentiation of GABA responses observed with the drugs. Thus, the drugs each increase the response to GABA but do not act on channel kinetics in the same manner.

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Metadata

Authors
Study, R. E., & Barker, J. L.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1981-11
Volume
78
Issue
11
Pages
7180-7184
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.78.11.7180
OpenAlex
W2068213581
Cited by
561
References
17
FWCI
7.40
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons. https://app.cochat.ai/papers/10.1073/pnas.78.11.7180
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Study, R. E., & Barker, J. L. (1981). Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.11.7180

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