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Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients
Abstract
We conducted a double‐blind pilot study of 8 patients with established cerebral infarction to evaluate the effect of a single dose of amphetamine on recovery of motor function using the Fugl‐Meyer scale. Four patients received amphetamine; the rest were given placebo. All underwent a session of physical therapy. Patients treated with amphetamine obtained greater increments in motor scores than the controls. Along with animal studies, these findings may allow the development of a pharmacological approach to stroke rehabilitation.
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Citations
Cited by
Neuroplasticity in the context of motor rehabilitation after stroke
Dimyan, M. A., & Cohen, L. G. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.200 · Cited by 732
National Clinical Guidelines for Stroke.
Robinson, T. (2001) · Postgraduate Medical Journal · doi:10.1136/pmj.77.906.286h · Cited by 608
Role of adaptive plasticity in recovery of function after damage to motor cortex
Nudo, R. J., Plautz, E. J., & Frost, S. B. (2001) · Muscle & Nerve · doi:10.1002/mus.1104 · Cited by 561
Noradrenergic mechanisms in neurodegenerative diseases: a theory
Marien, M. R., Colpaert, F. C., & Rosenquist, A. C. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.02.002 · Cited by 414
Robinson, R. G., Schultz, S. K., Castillo, C., Kopel, T., Kosier, J. T., Newman, R. M., Curdue, K., Petracca, G., & Starkstein, S. E. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.3.351 · Cited by 384
Metadata
- Authors
- Crisostomo, E. A., Duncan, P. W., Propst, M., Dawson, D. V., & Davis, J. N.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1988-01
- Volume
- 23
- Issue
- 1
- Pages
- 94-97
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2023600984
- Cited by
- 340
- References
- 0
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients. https://app.cochat.ai/papers/10.1002/ana.410230117
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- Crisostomo, E. A., Duncan, P. W., Propst, M., Dawson, D. V., & Davis, J. N. (1988). Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients. Annals of Neurology. https://doi.org/10.1002/ana.410230117
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
