The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Midbrain dopaminergic cell loss in parkinson's disease: Computer visualization
Abstract
Computer visualization techniques were used to map the distribution of dopaminergic neurons within midbrain tissue sections from 5 parkinsonian patients and 3 age‐matched control subjects. The Parkinsonian brains had over 50% fewer dopaminergic neurons within the midbrain than age‐matched normal brains. The cell loss occurred within the combined substantia nigra (dopaminergic nucleus A9) and retrorubral (dopaminergic nucleus A8) areas (> 61%) and the ventral tegmental area (dopaminergic nucleus A10) (> 42%). The cell loss was greatest within the ventral portion of the substantia nigra zona compacta. The specific pattern of cell loss is very similar to the pattern of cells that project to the striatum (as opposed to cortical and limbic sites) in animal neuroanatomical tracing experiments. These data suggest that Parkinson's disease preferentially destroys midbrain dopaminergic neurons in nuclei A8, A9, and A10, which project to the striatum.
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Cites
Estimation of nuclear population from microtome sections
Abercrombie, M. (1946) · The Anatomical Record · doi:10.1002/ar.1090940210 · Cited by 4,363
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301
A brainstem atlas of catecholaminergic neurons in man, using melanin as a natural marker
Bogerts, B. (1981) · Journal of Comparative Neurology · doi:10.1002/cne.901970106 · Cited by 177
CORRESPONDENCE OF MELANIN-PIGMENTED NEURONS IN HUMAN BRAIN WITH A1–A14 CATECHOLAMINE CELL ROUPS
SAPER, C. B., & PETITO, C. K. (1982) · Brain · doi:10.1093/brain/105.1.87 · Cited by 107
Self-citation
Cited by
Giovannoni, G. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.4.423 · Cited by 587
Chung, C. Y., Seo, H., Sonntag, K. C., Brooks, A., Lin, L., & Isacson, O. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi178 · Cited by 361
Frost, J. J., Rosier, A. J., Reich, S. G., Smith, J. S., Ehlers, M. D., Snyder, S. H., Ravert, H. T., & Dannals, R. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340331 · Cited by 320
Iron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis
Jellinger, K., Kienzl, E., Rumpelmair, G., Riederer, P., Stachelberger, H., Ben‐Shachar, D., & Youdim, M. B. H. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08362.x · Cited by 313
Dopamine dysregulation syndrome in Parkinson's disease
Evans, A. H., & Lees, A. J. (2004) · Current Opinion in Neurology · doi:10.1097/01.wco.0000137528.23126.41 · Cited by 257
Metadata
- Authors
- German, D. C., Manaye, K., Smith, W. K., Woodward, D. J., & Saper, C. B.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1989-10
- Volume
- 26
- Issue
- 4
- Pages
- 507-514
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2030187260
- Cited by
- 396
- References
- 4
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- German, D. C., Manaye, K., Smith, W. K., Woodward, D. J., & Saper, C. B. (1989). Midbrain dopaminergic cell loss in parkinson's disease: Computer visualization. Annals of Neurology. https://doi.org/10.1002/ana.410260403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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