The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Pathological markers associated with normal aging and dementia in the elderly
Abstract
We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median age of both groups, 88 years) who had been studied prospectively for 4.0 ± 2.1 years. Very old demented subjects almost always had nonneuritic senile plaques, but over half had no neuritic senile plaques and little other AD pathology. Five subjects had cortical Lewy bodies; all were demented. We propose that hippocampal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia. When grouped together, these markers were significantly associated with dementia and occurred in 40% of demented subjects. As the relative frequency of neuritic markers of AD (and possibly AD itself) declines in the tenth decade, vascular dementia may become an increasingly important type of dementia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast to the increased prevalence of clinical dementia with advanced age, the prevalence of cases with high NP and high NFT pathologic diagnosis at autopsy seems to level off in the oldest old according to multiple autopsy series (154, 168-172).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [154]
In the citing paper
“Thus, in the oldest old, the prevalence of concomitant non-AD brain diseases, including CVD and hippocampal sclerosis, begins to mimic the effects of AD pathologic diagnosis (154, 221, 222).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [154]
In the citing paper
“Numerous CPC studies have assessed the association between NFTs and cognitive status (38, 98, 154, 158, 162, 185, 188, 189, 191, 223-232, 235-240, 244, 250-252, 258, 261, 264, 287-296).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [154]
Citations
Cites
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818
Observations on the brains of non-demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1968) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(68)90154-8 · Cited by 681
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643
Self-citationCrystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586
Self-citationSenile dementia of Lewy body type
Perry, R. H., Irving, D., Blessed, G., FAIRBAIRN, A. F., & Perry, E. K. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90236-g · Cited by 575
Morris, J. C., McKeel, D. W., Storandt, M., Rubin, E. H., Price, J. L., Grant, E. A., Ball, M. J., & Berg, L. (1991) · Neurology · doi:10.1212/wnl.41.4.469 · Cited by 473
Development of dementing illnesses in an 80‐year‐old volunteer cohort
Katzman, R., Aronson, M., Fuld, P. A., Kawas, C. H., Brown, T., Morgenstern, H., Frishman, W. H., Gidez, L. I., Eder, H., & Ooi, W. L. (1989) · Annals of Neurology · doi:10.1002/ana.410250402 · Cited by 453
βA4 amyloid protein deposition in brain after head trauma
Roberts, G., Gentleman, S., Lynch, A., & Graham, D. I. (1991) · The Lancet · doi:10.1016/0140-6736(91)92724-g · Cited by 440
Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.
Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P. A., & Yen, S. H. (1988) · PubMed Central · Cited by 383
Self-citationA4 amyloid protein deposition and the diagnosis of Alzheimer's disease
Davies, L., Wolska, B., Hilbich, C., Multhaup, G., Martins, R. N., Simms, G., Beyreuther, K. T., & Masters, C. L. (1988) · Neurology · doi:10.1212/wnl.38.11.1688 · Cited by 369
Neuritic pathology and dementia in alzheimer's disease
McKee, A. C., Kosik, K. S., & Kowall, N. W. (1991) · Annals of Neurology · doi:10.1002/ana.410300206 · Cited by 358
Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease
Sparks, D. L., Hunsaker, J. C., Scheff, S. W., Kryscio, R. J., Henson, J. L., & Markesbery, W. R. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90024-t · Cited by 271
Senile Dementia of the Alzheimer Type Without Neocortical Neurofibrillary Tangles
Terry, R. D., Hansen, L. A., DeTeresa, R. M., Davies, P., Tobias, H., & Katzman, R. (1987) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198705000-00003 · Cited by 268
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90129-7 · Cited by 240
WHITE MATTER CHANGES IN DEMENTIA OF ALZHEIMER'S TYPE: BIOCHEMICAL AND NEUROPATHOLOGICAL CORRELATES
ENGLUND, E., BRUN, A., & ALLING, C. (1988) · Brain · doi:10.1093/brain/111.6.1425 · Cited by 228
Dickson, D. W., Davies, P., Mayeux, R. P., Crystal, H., Horoupian, D. S., Thompson, A. J., & Goldman, J. E. (1987) · Acta Neuropathologica · doi:10.1007/bf00686786 · Cited by 204
Self-citationDiffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques
Dickson, D. W., Crystal, H., Mattiace, L. A., Kress, Y., Schwagerl, A. L., Ksiȩżak-Reding, H., Davies, P., & Yen, S. H. (1989) · Acta Neuropathologica · doi:10.1007/bf00691284 · Cited by 203
Self-citationAntemortem diagnosis of diffuse Lewy body disease
Crystal, H., Dickson, D. W., Lizardi, J. E., Davies, P., & WOLFSON, L. I. (1990) · Neurology · doi:10.1212/wnl.40.10.1523 · Cited by 169
Self-citationMemantine prevents HIV coat protein‐induced neuronal injury in vitro
Lipton, S. A. (1992) · Neurology · doi:10.1212/wnl.42.7.1403 · Cited by 157
Dementia. Age-dependent incidence, prevalence, and mortality in the old old
Aronson, M. K. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.5.989 · Cited by 154
Dementia with bilateral medial tempora1 lobe ischemia
Volpe, B. T., & Petito, C. K. (1985) · Neurology · doi:10.1212/wnl.35.12.1793 · Cited by 139
How acute brain failure becomes chronic
Tatemichi, T. K. (1990) · Neurology · doi:10.1212/wnl.40.11.1652 · Cited by 133
del Ser, T., Bermejo, F., Portera, A., Arredondo, J., Bouras, C., & Constantinidis, J. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90052-o · Cited by 129
Chui, H. C. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520430102025 · Cited by 127
Fuld, P. A. (1977) · PsycTESTS Dataset · doi:10.1037/t06066-000 · Cited by 124
Specificity of the clinical diagnosis of dementia
Todorov, A. B., Go, R. C. P., Constantinidis, J., & Elston, R. C. (1975) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(75)90116-1 · Cited by 104
Aronson, M. K. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400050129024 · Cited by 80
Primary Degenerative Dementia Without Alzheimer Pathology
Clark, A. W., White, C. L., Manz, H. J., Parhad, I. M., Curry, B., Whitehouse, P. J., Lehmann, J. C., & Coyle, J. T. (1986) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100037136 · Cited by 71
Vascular dementia: neuropathologic alterations and metabolic brain changes
García, J. H., & Brown, G. G. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90158-h · Cited by 50
Mann, D. M. A., Jones, D., South, P. W., Snowden, J. S., & Neary, D. (1992) · Acta Neuropathologica · doi:10.1007/bf00713534 · Cited by 44
Masur, H., & Oberwittler, C. (1992) · Neurology · doi:10.1212/wnl.42.2.464 · Cited by 6
Neuropsychological characteristics of subjects with and without neocortical Alz-50 immunoreactivity.
Crystal, H., Davies, P., Dickson, D. W., Scicutella, A., Blau, A. D., & Masur, D. (1989) · PubMed · Cited by 2
Self-citationCrystal, H. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90262-v · Cited by 2
Self-citation
Research works printed but not linked: 4
- Crystal H, 1992, Does Alzheimer's disease cause most cases of dementia in the oldest‐old?, Neurology, 42, 358
- Lipton R, 1992, Clinical and pathologic diagnosis of Alzheimer's disease in the oldest‐old, Neurology, 42, 358
- Masur D, 1992, Association of neuropathology with patterns of neuropsychological decline in elderly subjects, Neurology, 42, 359
- Knopman DS, 1988, Dementia lacking distinctive histologic features: a common non‐Alzheimer degenerative dementia, Neurology, 47, 536
Cited by
Sorted by citations
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092
Self-citationNelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050
“Thus, in the oldest old, the prevalence of concomitant non-AD brain diseases, including CVD and hippocampal sclerosis, begins to mimic the effects of AD pathologic diagnosis (154, 221, 222).”
BackgroundInfluentialLimbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., et al. (2019) · Brain · doi:10.1093/brain/awz099 · Cited by 1,547
Self-citationNeuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336
Jack, C. R., Lowe, V. J., Senjem, M. L., Weigand, S. D., Kemp, B. J., Shiung, M. M., Knopman, D. S., Boeve, B. F., Klunk, W. E., Mathis, C. A., et al. (2008) · Brain · doi:10.1093/brain/awm336 · Cited by 958
Metadata
- Authors
- Crystal, H. A., Dickson, D. W., Sliwinski, M. J., Lipton, R. B., Grober, E., Marks‐Nelson, H., & Antis, P.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Crystal, Howard A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1993-10
- Volume
- 34
- Issue
- 4
- Pages
- 566-573
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2163665026
- Cited by
- 161
- References
- 37
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 9
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-O3949)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, dementia with Lewy bodies, vascular dementia, normal aging, dementia, cortical Lewy bodies, hippocampal sclerosis, leukoencephalopathy, cognitive function, older adults, pathological markers
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Cerebral Infarction, Dementia, Female, Hippocampus, Humans, Male, Dementia, Vascular, Lewy Bodies, Neurofibrillary Tangles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
