Identification of normal and pathological aging in prospectively studied nondemented elderly humans

Dickson, Dennis W.; Crystal, Howard A.; Mattiace, Linda A.; Masur, David M.; Blau, Alan D.; Davies, Peter; Yen, Shu-Hui; Aronson, Miriam K.

doi:10.1016/0197-4580(92)90027-u

Cited by 643Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

Dickson, Dennis W., Crystal, Howard A., Mattiace, Linda A., Masur, David M., Blau, Alan D., Davies, Peter, Yen, Shu-Hui, Aronson, Miriam K.·1992·Neurobiology of Aging

DOI 10.1016/0197-4580(92)90027-u

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Abstract

Results of a standardized histochemical and immunocytochemical analysis of the brains of 14 nondemented elderly humans for whom prospective neurological and neuropsychological data had been collected for 3 to 8 years before death suggested that nondemented elderly humans fall into two pathological subgroups that are not clinically distinguishable. One was associated with moderate to marked cerebral amyloid deposition ("pathological aging"), while the other had either minimal or no amyloid deposition ("normal aging"). Neocortical and hippocampal neurofibrillary degeneration was either completely absent or of very limited degree in both subgroups. Both subgroups had ubiquitin-immunoreactive dystrophic neurites in the cerebral cortex and granular degeneration of myelin in white matter. These ubiquitin-immunoreactive structures seem to be a universal and invariant manifestation of brain aging, but the same cannot be said for amyloid deposition and neurofibrillary degeneration. Pathological aging might be preclinical Alzheimer's disease, but it currently cannot be distinguished from normal aging by even sensitive neuropsychological measures. These findings provide strong support for the hypothesis that cerebral amyloid deposition is not necessarily associated with clinically apparent cognitive dysfunction and that additional factors, such as neuronal or synaptic loss or widespread cytoskeletal aberrations, are necessary for dementia in AD.

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Aβ alone is not predictive of AD.
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In contrast to previous qualitative observations, the type and number of A␤ deposits were similar in HPC and AD groups.
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From Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease (1999) · cites this paper as [3]

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Manual for the Wechsler Adult Intelligence Scale.
Wechsler, D. (1955) · Psychological Corp. eBooks · Cited by 4,941 · see citing works
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works
Human Aging: Usual and Successful
Rowe, J. W., & Kahn, R. L. (1987) · Science · doi:10.1126/science.3299702 · Cited by 3,384 · see citing works
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499 · see citing works
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Self-citation
Selective reminding for analysis of memory and learning
Buschke, H. (1973) · Journal of Verbal Learning and Verbal Behavior · doi:10.1016/s0022-5371(73)80034-9 · Cited by 1,063 · see citing works
共やくエクイン・エストロゲン(Premarin)服用閉経婦人の血清エクイリン,エストロン,エストラジオール値
Whittaker, P. G., Morgan, M. R., Dean, P., Cameron, E., & Lind, T. (1980) · The Lancet · Cited by 724 · see citing works
Observations on the brains of non-demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1968) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(68)90154-8 · Cited by 681 · see citing works
Perforant pathway changes and the memory impairment of Alzheimer's disease
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672 · see citing works
Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 652 · see citing works
Plaques, tangles and dementia
Wilcock, G. K., & Esiri, M. M. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90155-1 · Cited by 608 · see citing works
Clinico‐pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease
Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586 · see citing works
Self-citation
A Neuronal Antigen in the Brains of Alzheimer Patients
Wolozin, B. L., Pruchnicki, A., Dickson, D. W., & Davies, P. (1986) · Science · doi:10.1126/science.3083509 · Cited by 585 · see citing works
Self-citation
Alzheimer's disease
Wilcock, G. K., Esiri, M. M., Bowen, D. M., & Smith, C. C. T. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90045-4 · Cited by 553 · see citing works
The occult aftermath of boxing.
Roberts, G. W., Allsop, D., & Bruton, C. (1990) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.5.373 · Cited by 518 · see citing works
Very mild Alzheimer's disease: Informant‐based clinical, psychometric, and pathologic distinction from normal aging
Morris, J. C., McKeel, D. W., Storandt, M., Rubin, E. H., Price, J. L., Grant, E. A., Ball, M. J., & Berg, L. (1991) · Neurology · doi:10.1212/wnl.41.4.469 · Cited by 473 · see citing works
The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
Mann, D. M. A., & Esiri, M. M. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90019-1 · Cited by 471 · see citing works
Development of dementing illnesses in an 80‐year‐old volunteer cohort
Katzman, R., Aronson, M., Fuld, P. A., Kawas, C. H., Brown, T., Morgenstern, H., Frishman, W. H., Gidez, L. I., Eder, H., & Ooi, W. L. (1989) · Annals of Neurology · doi:10.1002/ana.410250402 · Cited by 453 · see citing works
Self-citation
Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90288-0 · Cited by 432 · see citing works
A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA
Ball, M. J., Hachinski, V., Fox, A. J., Kirshen, A. J., Fisman, M., Blume, W. T., Kral, V. A., Fox, H., & Merskey, H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90965-1 · Cited by 427 · see citing works
Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.
Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P. A., & Yen, S. H. (1988) · PubMed Central · Cited by 383 · see citing works
Self-citation
Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
Masliah, E., Terry, R. D., DeTeresa, R. M., & Hansen, L. A. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90582-x · Cited by 363 · see citing works
Neuritic pathology and dementia in alzheimer's disease
McKee, A. C., Kosik, K. S., & Kowall, N. W. (1991) · Annals of Neurology · doi:10.1002/ana.410300206 · Cited by 358 · see citing works
A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining
YAMAGUCHI, H., Hirai, S., Morimatsu, M., Shoji, M., & Ihara, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00689591 · Cited by 283 · see citing works
Senile Dementia of the Alzheimer Type Without Neocortical Neurofibrillary Tangles
Terry, R. D., Hansen, L. A., DeTeresa, R. M., Davies, P., Tobias, H., & Katzman, R. (1987) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198705000-00003 · Cited by 268 · see citing works
Self-citation
Women, myocardial infarction, and dementia in the very old
Aronson, M. K., Ooi, W. L., Morgenstern, H., Hafner, A. R., Masur, D., Crystal, H., Frishman, W. H., Fisher, D., & Katzman, R. (1990) · Neurology · doi:10.1212/wnl.40.7.1102 · Cited by 257 · see citing works
Self-citation
Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques
Dickson, D. W., Crystal, H., Mattiace, L. A., Kress, Y., Schwagerl, A. L., Ksiȩżak-Reding, H., Davies, P., & Yen, S. H. (1989) · Acta Neuropathologica · doi:10.1007/bf00691284 · Cited by 203 · see citing works
Self-citation
Large amounts of neocortical βA4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person
Delaère, P., Duyckaerts, C., Masters, C., Beyreuther, K., Piette, F., & Hauw, J.-J. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90391-l · Cited by 186 · see citing works
Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects.
Dickson, D. W., Wertkin, A. M., Kress, Y., Ksiȩżak-Reding, H., & Yen, S.-H. (1990) · PubMed · Cited by 169 · see citing works
Self-citation
Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia
Braak, H., & Braak, E. (1990) · Acta Neuropathologica · doi:10.1007/bf00294607 · Cited by 135 · see citing works
PATHOLOGIC CHANGES IN SENILE PSYCHOSES AND THEIR PSYCHOBIOLOGIC SIGNIFICANCE
Rothschild, D., & Trainor, M. A. (1937) · American Journal of Psychiatry · doi:10.1176/ajp.93.4.757 · Cited by 126 · see citing works
Distinguishing normal and demented elderly with the selective reminding test
Masur, D. M., Fuld, P. A., Blau, A. D., Thal, L. J., Levin, H. S., & Aronson, M. K. (1989) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688638908400920 · Cited by 110 · see citing works
Self-citation
Alz 50, a monoclonal antibody to Alzheimer's disease antigen, cross-reacts with tau proteins from bovine and normal human brain.
Ksiȩżak-Reding, H., Davies, P., & Yen, S. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68425-x · Cited by 109 · see citing works
Self-citation
Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.
Wolozin, B. L., Scicutella, A., & Davies, P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.16.6202 · Cited by 104 · see citing works
Self-citation
About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation
Barcikowska, M., Wisniewski, H. M., Bancher, C., & Grundke, I. (1989) · Acta Neuropathologica · doi:10.1007/bf00687751 · Cited by 103 · see citing works
A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease.
Esiri, M. M., Pearson, R. C. A., Steele, J. E., et al. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.2.161 · Cited by 93 · see citing works
Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease
Selkoe, D. J. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90072-9 · Cited by 90 · see citing works
Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy.
Dickson, D. W., Kress, Y., Crowe, A., & Yen, S. H. (1985) · PubMed Central · Cited by 71 · see citing works
Self-citation
Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease
Duyckaerts, C., Delaère, P., Poulain, V., Brion, J.-P., & Hauw, J.-J. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90706-9 · Cited by 65 · see citing works
A Study of Infantile Motor Neuron Disease with Neurofilament and Ubiquitin Immunocytochemistry*
Lee, S., Park, Y., Yen, S. H., Ksiȩżak-Reding, H., Goldman, J. E., & Dickson, D. W. (1989) · Neuropediatrics · doi:10.1055/s-2008-1071275 · Cited by 61 · see citing works
Self-citation
A Progressive Deposition of Paired Helical Filaments (PHF) in the Brain Characterizes the Evolution of Dementia in Alzheimerʼs Disease.
Mena, R., Wischik, C. M., Novák, M., Milstein, C., & Cuello, A. C. (1991) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199107000-00008 · Cited by 59 · see citing works
Increased tau accumulation in senile plaques as a hallmark in Alzheimer's disease.
Shin, R., Ogomori, K., Kitamoto, T., & Tateishi, J. (1989) · Europe PMC (PubMed Central) · Cited by 58 · see citing works
Correlation between microscopical changes and Tau 64 and 69 biochemical detection in senile dementia of the Alzheimer type
Flament, S., Delacourte, A., Delaère, P., Duyckaerts, C. J., & Hauw, J. (1990) · Acta Neuropathologica · doi:10.1007/bf00308927 · Cited by 51 · see citing works
Recall and recognition as diagnostic indices of Malignant Memory loss in senile dementia: A bayesian analysis
Branconnier, R. J., Cole, J. O., Spera, K. F., et al. (1982) · Experimental Aging Research · doi:10.1080/03610738208260364 · Cited by 50 · see citing works
Astrocytes and microglia in human brain share an epitope recognized by a B-lymphocyte-specific monoclonal antibody (LN-1).
Dickson, D. W., & Mattiace, L. A. (1989) · PubMed Central · Cited by 38 · see citing works
Self-citation
Ubiquitin-immunoreactive Dystrophic Neurites in Downʼs Syndrome Brains
Mattiace, L. A., Kress, Y., Davies, P., Ksiȩżak-Reding, H., Yen, S. H., & Dickson, D. W. (1991) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199109000-00003 · Cited by 28 · see citing works
Self-citation
UBIQUITIN IMMUNOREACTIVE STRUCTURES IN NORMAL BRAINS
Dickson, D. W., Wertkin, A. M., Kress, Y., Ksiszek-Reding, H., & Yen, S. H. (1990) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199005000-00135 · Cited by 11 · see citing works
Self-citation
Increased tau accumulation in senile plaques as a hallmark in Alzheimer's disease
辛, 龍. (1991) · Medical Entomology and Zoology · doi:10.11501/3054141 · Cited by 3 · see citing works
NEUROPSYCHOLOGICAL CHARACTERISTICS OF SUBJECTS WITH AND WITHOUT CORTICAL ALZ50 IMMUNOREACTIVITY
Crystal, H., Davies, P. J., & Dickson, D. W. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802030-00020 · Cited by 2 · see citing works
Self-citation

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The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
“There is evidence to suggest that the latter lesions correlate better with cognitive impairment than amyloid deposits [55].”
BackgroundSelf-citation
National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Self-citation
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Self-citation
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
Lue, L.-F., Kuo, Y.-M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., & Rogers, J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65184-x · Cited by 1,530 · see citing works
Neuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336 · see citing works
Life and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344 · see citing works
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · see citing works
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works
Frequent amyloid deposition without significant cognitive impairment among the elderly
Aizenstein, H. J., Nebes, R. D., Saxton, J. A., Price, J. C., Mathis, C. A., Tsopelas, N. D., Ziolko, S. K., James, J. A., Snitz, B. E., Houck, P. R., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1509 · Cited by 1,059 · see citing works
Classification and basic pathology of Alzheimer disease
Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031 · see citing works
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works
Microglia as neuroprotective, immunocompetent cells of the CNS
Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919 · see citing works
The pathological process underlying Alzheimer’s disease in individuals under thirty
Braak, H., & Del Tredici, K. (2011) · Acta Neuropathologica · doi:10.1007/s00401-010-0789-4 · Cited by 812 · see citing works
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
Reiman, E. M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Keppler, J., Reeder, S. A., Langbaum, J. B. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900345106 · Cited by 785 · see citing works
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease
Streit, W. J., Braak, H., Xue, Q.-S., & Bechmann, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0556-6 · Cited by 727 · see citing works
Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry
Hamilton, R. L. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00269.x · Cited by 754 · see citing works
Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
Readhead, B., Haure-Mirande, J.-V., Funk, C. C., Richards, M. A., Shannon, P., Haroutunian, V., Sano, M., Liang, W. S., Beckmann, N. D., Price, N. D., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.023 · Cited by 708 · see citing works
Neuropathology of Cognitively Normal Elderly
Knopman, D. S., Parisi, J. E., Salviati, A., Floriach-Robert, M., Boeve, B. F., Ivnik, R. J., Smith, G. E., Dickson, D. W., Johnson, K. A., Petersen, L. E., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.11.1087 · Cited by 674 · see citing works
Self-citation
Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease
Price, J. L., McKeel, D. W., Buckles, V. D., Roe, C. M., Xiong, C., Grundman, M., Hansen, L. A., Petersen, R. C., Parisi, J. E., Dickson, D. W., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.002 · Cited by 661 · see citing works
Self-citation
Clinicopathologic Studies in Cognitively Healthy Aging and Alzheimer Disease: Relation of Histologic Markers to Dementia Severity, Age, Sex, and Apolipoprotein E Genotype
Berg, L., McKeel, D. W., Miller, J. P., Storandt, M., Rubin, E. H., Morris, J. C., Baty, J., Coats, M., Norton, J., Goate, A. M., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.3.326 · Cited by 657 · see citing works
Mechanisms of tau-induced neurodegeneration
Iqbal, K., Liu, F., Gong, C.-X., Alonso, A. D. C., & Grundke-Iqbal, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0486-3 · Cited by 628 · see citing works
Stanley Fahn Lecture 2005: the staging procedure for the inclusion body pathology associated with sporadic Parkinson’s disease reconsidered
Braak, H., Bohl, J. R., Müller, C. M., Rüb, U., de Vos, R. A. I., & Del Tredici, K. (2006) · Movement Disorders · doi:10.1002/mds.21065 · Cited by 630 · see citing works
Neuropathologic Features of Amnestic Mild Cognitive Impairment
Petersen, R. C., Parisi, J. E., Dickson, D. W., Johnson, K. A., Knopman, D. S., Boeve, B. F., Jicha, G. A., Ivnik, R. J., Smith, G. E., Tangalos, E. G., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.665 · Cited by 616 · see citing works
Self-citation
Cerebral amyloid deposition and diffuse plaques in ``normal'' aging: Evidence for presymptomatic and very mild Alzheimer's disease
Morris, J. C., Storandt, M., McKeel, D. W., Rubin, E. H., Price, J. L., Grant, E. A., & Berg, L. (1996) · Neurology · doi:10.1212/wnl.46.3.707 · Cited by 603 · see citing works
The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging
Wang, J., Dickson, D. W., Trojanowski, J. Q., & Lee, V. M.-Y. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7085 · Cited by 567 · see citing works
Self-citation
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease
Bierer, L. M., Hof, P. R., Purohit, D. P., Carlin, L., Schmeidler, J., Davis, K. L., & Perl, D. P. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540250089017 · Cited by 514 · see citing works
Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R., & Savonenko, A. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5080-04.2005 · Cited by 517 · see citing works
Pathologic Correlates of Nondemented Aging, Mild Cognitive Impairment, and Early-Stage Alzheimer's Disease
Morris, J. C., & Price, J. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:101 · Cited by 513 · see citing works
Invited review: Neuropathology of tauopathies: principles and practice
Kovacs, G. G. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12208 · Cited by 492 · see citing works
The importance of neuritic plaques and tangles to the development and evolution of AD
Tiraboschi, P., Hansen, L. A., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000129697.01779.0a · Cited by 477 · see citing works
Diagnostic Criteria for Neuropathologic Assessment of Alzheimer’s Disease
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00062-6 · Cited by 410 · see citing works
Correlations of synaptic and pathological markers with cognition of the elderly
Dickson, D. W., Crystal, H. A., Bevona, C., Honer, W., Vincent, I., & Davies, P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00013-5 · Cited by 410 · see citing works
Self-citation
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
Ikonomovic, M. D., Uryu, K., Abrahamson, E. E., Ciallella, J. R., Trojanowski, J. Q., Lee, V. M.-Y., Clark, R. S., Marion, D. W., Wisniewski, S. R., & DeKosky, S. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.011 · Cited by 399 · see citing works
The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind
Ricciarelli, R., & Fedele, E. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170116143743 · Cited by 380 · see citing works
“Preclinical” AD revisited: Neuropathology of cognitively normal older adults
Schmitt, F. A., Davis, D. G., Wekstein, D. R., Smith, C. D., Ashford, J. W., & Markesbery, W. R. (2000) · Neurology · doi:10.1212/wnl.55.3.370 · Cited by 369 · see citing works
Synaptic and neuritic alterations during the progression of Alzheimer's disease
Masliah, E., Mallory, M., Hansen, L., Richard, D., Alford, M., & Terry, R. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90121-x · Cited by 370 · see citing works
Cerebral amyloid angiopathy and cognitive function: The HAAS autopsy study
Pfeifer, L. A., White, L. R., Ross, G. W., Petrovitch, H., & Launer, L. J. (2002) · Neurology · doi:10.1212/wnl.58.11.1629 · Cited by 338 · see citing works
Clinicopathologic and<sup>11</sup>C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum
Murray, M. E., Lowe, V. J., Graff-Radford, N. R., Liesinger, A. M., Cannon, A., Przybelski, S. A., Rawal, B., Parisi, J. E., Petersen, R. C., Kantarci, K., et al. (2015) · Brain · doi:10.1093/brain/awv050 · Cited by 324 · see citing works
Self-citation
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
Tomic, J. L., Pensalfini, A., Head, E., & Glabe, C. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.024 · Cited by 336 · see citing works
Microglia and Alzheimer's disease pathogenesis
Streit, W. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20093 · Cited by 335 · see citing works
Microglial pathology
Streit, W. J., Xue, Q.-S., Tischer, J., & Bechmann, I. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0142-6 · Cited by 317 · see citing works
β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
Cummings, B. J., Pike, C. J., Shankle, R., & Cotman, C. W. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00170-4 · Cited by 305 · see citing works
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
Julien, C., Tremblay, C., Phivilay, A., Berthiaume, L., Émond, V., Julien, P., & Calon, F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.022 · Cited by 288 · see citing works
Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies
Shinohara, M., Tachibana, M., Kanekiyo, T., & Bu, G. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075796 · Cited by 297 · see citing works
Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Elderly Patients: A Quantitative Evaluation of a One-Year Autopsy Population from a Geriatric Hospital
Bouras, C., Hof, P. R., Giannakopoulos, P., Michel, J.-P., & Morrison, J. H. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.2.138 · Cited by 280 · see citing works
Argyrophilic Grain Disease Is a Sporadic 4-Repeat Tauopathy
Togo, T., Sahara, N., Yen, S.-H., Cookson, N., Ishizawa, T., Hutton, M., de Silva, R., Lees, A., & Dickson, D. W. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.6.547 · Cited by 273 · see citing works
Self-citation
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer’s disease
Pei, J.-J., Braak, H., An, W.-L., Winblad, B., Cowburn, R. F., Iqbal, K., & Grundke-Iqbal, I. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00488-6 · Cited by 247 · see citing works
Microglia in the aging brain: relevance to neurodegeneration
Luo, X.-G., Ding, J.-Q., & Chen, S.-D. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-12 · Cited by 236 · see citing works
“It is still uncertain what triggers the microglial activation in the healthy aged brain; whether it is caused by degenerating neurons or by abnormal protein aggregation found in clinically normal elders is still unknown[22].”
Background
Beta‐amyloid deposition and the aging brain
Rodrigue, K. M., Kennedy, K. M., & Park, D. C. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9118-x · Cited by 230 · see citing works
AD lesions and infarcts in demented and non‐demented Japanese‐American men
Petrovitch, H., Ross, G. W., Steinhorn, S. C., Abbott, R. D., Markesbery, W., Davis, D., Nelson, J., Hardman, J., Masaki, K., Vogt, M. R., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20318 · Cited by 230 · see citing works
Immune reactive cells in senile plaques and cognitive decline in Alzheimer’s disease
Vehmas, A. K., Kawas, C. H., Stewart, W. F., & Troncoso, J. C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00090-8 · Cited by 230 · see citing works
Clinical subtypes of Alzheimer’s disease
Petersen, R. C. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051199 · Cited by 223 · see citing works
Lewy Body Pathology in Normal Elderly Subjects
Markesbery, W. R., Jicha, G. A., Liu, H., & Schmitt, F. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181ac10a7 · Cited by 210 · see citing works
Does Alzheimer's disease begin in the brainstem?
Simic, G., Stanic, G., Mladinov, M., Jovanov‐Milosevic, N., Kostovic, I., & Hof, P. R. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01038.x · Cited by 204 · see citing works
Alzheimer disease pathology as a host response
Castellani, R. J., Lee, H.-G., Zhu, X., Perry, G., & Smith, M. A. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318177eaf4 · Cited by 171 · see citing works
Neuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies
Dickson, D. W. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00065-1 · Cited by 168 · see citing works
Self-citation
Pathological markers associated with normal aging and dementia in the elderly
Crystal, H. A., Dickson, D. W., Sliwinski, M. J., Lipton, R. B., Grober, E., Marks‐Nelson, H., & Antis, P. (1993) · Annals of Neurology · doi:10.1002/ana.410340410 · Cited by 161 · see citing works
Self-citation
The Relative Frequency of "Dementia of Unknown Etiology" Increases With Age and Is Nearly 50% in Nonagenarians
Crystal, H. A., Dickson, D., Davies, P., Masur, D., Grober, E., & Lipton, R. B. (2000) · Archives of Neurology · doi:10.1001/archneur.57.5.713 · Cited by 152 · see citing works
Self-citation
βA4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 french centenarians
Delaère, P., He, Y., Fayet, G., Duyckaerts, C., & Hauw, J.-J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90096-t · Cited by 149 · see citing works
Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging
Troncoso, J. C., Martin, L. J., Dal Forno, G., & Kawas, C. H. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00028-0 · Cited by 138 · see citing works
Parenchymal and vascular Aβ‐deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease
Thal, D. R., Griffin, W. S. T., & Braak, H. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00411.x · Cited by 134 · see citing works
Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal Study on Dementia
Bancher, C., Jellinger, K., Lassmann, H., Fischer, P., & Leblhuber, F. (1996) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02189115 · Cited by 130 · see citing works
The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease
Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128 · see citing works
Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer’s disease
Arnold, S. E., Louneva, N., Cao, K., Wang, L.-S., Han, L.-Y., Wolk, D. A., Negash, S., Leurgans, S. E., Schneider, J. A., Buchman, A. S., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.03.004 · Cited by 123 · see citing works
Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer’s disease
Bussire, T., Gold, G., Kvari, E., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00942-9 · Cited by 122 · see citing works
Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer’s disease
Shinohara, M., Fujioka, S., Murray, M. E., Wojtas, A., Baker, M., Rovelet-Lecrux, A., Rademakers, R., Das, P., Parisi, J. E., Graff-Radford, N. R., et al. (2014) · Brain · doi:10.1093/brain/awu046 · Cited by 115 · see citing works
Self-citation
Prevalence, incidence and duration of Braak's stages in the general population: can we know?
Duyckaerts, C., & Hauw, J.-J. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00047-x · Cited by 109 · see citing works
Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis
Li, H., Liu, C.-C., Zheng, H., & Huang, T. Y. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0139-3 · Cited by 103 · see citing works
Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer’s disease
Potter, P. E., Rauschkolb, P. K., Pandya, Y., Sue, L. I., Sabbagh, M. N., Walker, D. G., & Beach, T. G. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0831-1 · Cited by 94 · see citing works
Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer’s disease pathology
Scheff, S. W., Ansari, M. A., & Mufson, E. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.030 · Cited by 100 · see citing works
Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
Lowe, V. J., Lundt, E. S., Albertson, S. M., Przybelski, S. A., Senjem, M. L., Parisi, J. E., Kantarci, K., Boeve, B., Jones, D. T., Knopman, D., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.03.016 · Cited by 90 · see citing works
Self-citation
Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome
Head, E., Garzon-Rodriguez, W., Johnson, J. K., Lott, I. T., Cotman, C. W., & Glabe, C. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0431 · Cited by 75 · see citing works
Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease
von Gunten, A., Bouras, C., Kövari, E., Giannakopoulos, P., & Hof, P. R. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.003 · Cited by 75 · see citing works
Striatal amyloid plaque density predicts braak neurofibrillary stage and clinicopathological Alzheimer's disease: Implications for amyloid imaging
Beach, T. G., Sue, L. I., Walker, D. G., Sabbagh, M. N., Serrano, G., Dugger, B. N., Mariner, M., Yantos, K., Henry-Watson, J., Chiarolanza, G., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111340 · Cited by 74 · see citing works
The prevalence of the neuropathological lesions of Alzheimer’s disease is independent of race and gender
Sandberg, G., Stewart, W., Smialek, J., & Troncoso, J. C. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00236-0 · Cited by 68 · see citing works
Untangling senescent and damage‐associated microglia in the aging and diseased brain
Ng, P. Y., McNeely, T. L., & Baker, D. J. (2023) · The FEBS Journal · doi:10.1111/febs.16315 · Cited by 68 · see citing works
Pathological changes in frontal cortex from biopsy to autopsy in Alzheimer's disease
Bennett, D. A., Cochran, E. J., Saper, C. B., Leverenz, J. B., Gilley, D. W., & Wilson, R. S. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90043-b · Cited by 67 · see citing works
<sup>11</sup> C-PIB-PET for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI)
Zhang, S., Smailagic, N., Hyde, C., Noel-Storr, A. H., Takwoingi, Y., McShane, R., & Feng, J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010386.pub2 · Cited by 66 · see citing works
Brain Aging in the Oldest-Old
von Gunten, A., Ebbing, K., Imhof, A., Giannakopoulos, P., & Kövari, E. (2010) · Current Gerontology and Geriatrics Research · doi:10.1155/2010/358531 · Cited by 62 · see citing works
Lexical and Acoustic Speech Features Relating to Alzheimer Disease Pathology
Cho, S., Cousins, K. A. Q., Shellikeri, S., Ash, S., Irwin, D. J., Liberman, M. Y., Grossman, M., & Nevler, N. (2022) · Neurology · doi:10.1212/wnl.0000000000200581 · Cited by 51 · see citing works
Mechanisms of cell death in Alzheimer’s disease
Bancher, C., Lassmann, H., Breitschopf, H., & Jellinger, K. A. (1997) · Journal of Neural Transmission. Supplementa · doi:10.1007/978-3-7091-6842-4_14 · Cited by 50 · see citing works
Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells
Wang, L., Jiang, Q., Chu, J., Lin, L., Li, X.-G., Chai, G.-S., Wang, Q., Wang, J.-Z., & Tian, Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076057 · Cited by 47 · see citing works
Evidence that transmitter‐containing dystrophic neurites precede paired helical filament and Alz‐50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease
Benzing, W. C., Ikonomovic, M. D., Brady, D. R., Mufson, E. J., & Armstrong, D. M. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903340203 · Cited by 46 · see citing works
An immunohistochemical study of centenarian brains: a comparison
Itoh, Y., Yamada, M., Suematsu, N., Matsushita, M., & Otomo, E. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00050-1 · Cited by 45 · see citing works
The Role of Microglial Cellular Senescence in the Aging and Alzheimer Diseased Brain
Flanary, B. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.82 · Cited by 40 · see citing works
A third of community-dwelling elderly with intermediate and high level of Alzheimer’s neuropathologic changes are not demented: A meta-analysis
Azarpazhooh, M. R., Avan, A., Cipriano, L. E., Munoz, D. G., Erfanian, M., Amiri, A., Stranges, S., & Hachinski, V. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.101002 · Cited by 32 · see citing works
Genes, pathways and risk prediction in Alzheimer’s disease
Hardy, J., & Escott-Price, V. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz163 · Cited by 27 · see citing works
Initial assessment of the spatial learning, reversal, and sequencing task capabilities of knock-in rats with humanizing mutations in the Aβ-coding region of App
Pham, H., Yin, T., & D’Adamio, L. (2022) · PLOS ONE · doi:10.1371/journal.pone.0263546 · Cited by 6 · see citing works
Mismatch between plaques and tangles in staging Alzheimer pathology
Dickson, D. W. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)97325-b · Cited by 2 · see citing works
Self-citation
Frontotemporal dementia: does structural MRI-based clustering match clinical syndromes?
Singh-Reilly, N., Sintini, I., Ali, F., Duffy, J. R., Clark, H. M., Utianski, R. L., Meade, G., Machulda, M. M., Satoh, R., Lowe, V. J., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1771092

P3‐312: Brain Iron Levels Associated With Increased Alzheimer's Disease Neuropathology
Morris, M. C., Bush, A. I., Ayton, S., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.1976 · Cited by 1 · see citing works
P2–206: Cerebral amyloid angiopathy and its co‐occurrence with Alzheimer's disease in the National Alzheimer's Coordinating Center Neuropathology data set
Brenowitz, W. D., Nelson, P. T., Besser, L. M., Bristow, K., & Kukull, W. A. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.852
Interaction of Neuritic Plaques and Education Predicts Dementia
Roe, C. M., Xiong, C., Miller, J. P., Cairns, N. J., & Morris, J. C. (2008) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181610fff · Cited by 32 · see citing works
Alzheimer’s disease and Down syndrome
Pelt, K. L. V., Head, E., Schmitt, F. A., & Koehl, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813955-4.00020-9 · Cited by 5 · see citing works
Plasma Biomarkers of Amyloid and Neurodegeneration predictive of Neuropathologic Scales of Cerebrovascular Disease
Graff‐Radford, J., Mielke, M. M., Hofrenning, E. I., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.067350 · Cited by 1 · see citing works

Authors: Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Dickson, Dennis W.
ORCID: Dickson, Dennis W.
Davies, Peter
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1992-01
Volume: 13
Issue: 1
Pages: 179-189
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/0197-4580(92)90027-u
OpenAlex: W2070137740
Cited by: 643
References: 53
Citations by year: 2026: 5 · 2025: 14 · 2024: 19 · 2023: 14 · 2022: 19 · 2021: 21 · 2020: 17 · 2019: 22 · 2018: 14 · 2017: 13 · 2016: 19 · 2015: 28 · 2014: 22 · 2013: 16 · 2012: 19
FWCI: 22.95
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ns019234-05, 5p01ag006803-11)
National Institute on Aging (AG-06803, AG03949, P01AG003949)
National Institute of Neurological Disorders and Stroke (NS-19234)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: normal aging, pathological aging, cerebral amyloid deposition, preclinical Alzheimer's disease, neurofibrillary degeneration, hippocampus, cerebral cortex, dementia, cognitive impairment
MeSH terms: Aged, Aged, 80 and over, Aging, Alzheimer Disease, Cerebral Cortex, Female, Frontal Lobe, Hippocampus, Humans, Immunohistochemistry, Male, Memory Disorders, Nerve Degeneration, Prospective Studies, Reference Values, Thiazoles, Ubiquitins, Visual Cortex, Wechsler Scales, Cerebral Amyloid Angiopathy, Neurofibrillary Tangles, Benzothiazoles

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Identification of normal and pathological aging in prospectively studied nondemented elderly humans

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