The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Evidence for long‐term survival and function of dopaminergic grafts in progressive Parkinson's disease
Abstract
Two patients with idiopathic Parkinson's disease (Patients 3 and 4 in our series) were followed up to 3 years after grafting of human embryonic dopamine‐rich mesencephalic tissue unilaterally into the putamen. During the first postoperative year both patients showed significant amelioration of parkinsonian symptoms and increased 6‐L‐[18 F]‐fluorodopa uptake in the grafted putamen, as assessed with positron emission tomography. Three years after grafting the patients still exhibited increased fluorodopa uptake in the grafted putamen and significant clinical improvements, evidenced by a reduction of the severity of symptoms and of the time spent in the “off” phase, and by a prolongation of the effect of a single dose of L‐dopa. Between 1 and 3 years after surgery, Patient 3 showed only minor changes of parkinsonian symptoms on the side contralateral to the graft, whereas there was a worsening on the ipsilateral side. Fluorodopa uptake decreased in the nongrafted putamen but was unchanged in the grafted putamen. Patient 4 continued to improve after the first postoperative year and L‐dopa was withdrawn after 32 months. The reduction of parkinsonian symptoms on the side contralateral to the graft became more pronounced between 1 and 3 years after surgery. Fluorodopa uptake further increased in the grafted putamen, whereas no change was detected on the non‐grafted side. These results indicate that grafts of embryonic dopamine neurons can survive, grow, and exert functional effects up to at least 3 years after surgery in the parkinsonian brain, despite an ongoing disease process leading to degeneration of the intrinsic dopamine system.
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Cites
Grafts of Fetal Dopamine Neurons Survive and Improve Motor Function in Parkinson's Disease
Lindvall, O., Brundin, P., Widner, H., Rehncrona, S., Gustavii, B., Frackowiak, R., Leenders, K. L., Sawle, G., Rothwell, J. C., Marsden, C. D., et al. (1990) · Science · doi:10.1126/science.2105529 · Cited by 1,207
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Self-citationThe Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease
Tetrud, J. W., & Langston, J. W. (1989) · Science · doi:10.1126/science.2502843 · Cited by 638
Lindvall, O. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520420033021 · Cited by 535
Self-citationDISTURBANCE OF SEQUENTIAL MOVEMENTS IN PATIENTS WITH PARKINSON'S DISEASE
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Self-citationTransplantation of Human Fetal Dopamine Cells for Parkinson's Disease: Results at 1 Year
Freed, C. R. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530050021007 · Cited by 242
Sawle, G. V., Bloomfield, P. M., Ourklund, A. B., Brooks, D. J., Brundin, P., Leenders, K. L., Lindvall, O., Marsden, C. D., Rehncrona, S., Widner, H., et al. (1992) · Annals of Neurology · doi:10.1002/ana.410310207 · Cited by 201
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Cited by
Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease
Freed, C. R., Greene, P. E., Breeze, R. E., Tsai, W.-Y., DuMouchel, W., Kao, R., Dillon, S., Winfield, H., Culver, S., Trojanowski, J. Q., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441002 · Cited by 2,366
A double‐blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
Olanow, C. W., Goetz, C. G., Kordower, J. H., Stoessl, A. J., Sossi, V., Brin, M. F., Shannon, K. M., Nauert, G. M., Perl, D. P., Godbold, J., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10720 · Cited by 1,307
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Long-term Evaluation of Bilateral Fetal Nigral Transplantation in Parkinson Disease
Hauser, R. A., Freeman, T. B., Snow, B. J., Nauert, M., Gauger, L., Kordower, J. H., & Olanow, C. W. (1999) · Archives of Neurology · doi:10.1001/archneur.56.2.179 · Cited by 353
Li, W., Englund, E., Widner, H., Mattsson, B., van Westen, D., Lätt, J., Rehncrona, S., Brundin, P., Björklund, A., Lindvall, O., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605245113 · Cited by 313
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Metadata
- Authors
- Lindvall, O., Sawle, G., Widner, H., Rothwell, J. C., Björklund, A., Brooks, D., Brundin, P., Frackowiak, R., Marsden, C. D., Odin, P., & Rehncrona, S.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1994-02
- Volume
- 35
- Issue
- 2
- Pages
- 172-180
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2084543881
- Cited by
- 451
- References
- 15
- FWCI
- 20.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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