The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Transplantation of fetal dopamine neurons in Parkinson's disease: One‐year clinical and neurophysiological observations in two patients with putaminal implants
Abstract
Ventral mesencephalic tissue from aborted human fetuses (age, 6–7 weeks' postconception) was implanted unilaterally into the putamen using stereotaxic surgery in 2 immunosuppressed patients (Patients 3 and 4 in our series) with advanced idiopathic Parkinson's disease. Tissue from 4 fetuses was grafted to each patient. Compared with our previous 2 patients, the following changes in the grafting procedure were introduced: the implantation instrument was thinner, more tissue was placed in the operated structure, and the time between abortion and grafting was shorter. There were no postoperative complications. Both patients showed a gradual and significant amelioration of parkinsonian symptoms (most marked in Patient 3) starting at 6 and 12 weeks after grafting, respectively, reaching maximum stability at approximately 4 to 5 months; patients remained relatively stable thereafter during the 1‐year follow‐up period. Clinical improvement was observed as a reduction of the time spent in the “off” phase and the number of daily “off” periods; a lessening of bradykinesia and rigidity during the “off” phase, mainly but not solely on the side contralateral to the graft; and a prolongation and change in the pattern of the effect of a single dose of L‐dopa. Neurophysiological measurements revealed a more rapid performance of simple and complex arm and hand movements bilaterally, but primarily contralateral to the graft. The results indicate that patients with Parkinson's disease can show significant and sustained improvement of motor function after intrastriatal implantation of fetal dopamine‐rich mesencephalic tissue. The accompanying paper by Sawle and colleagues describes the results of repeated positron emission tomography scans in these patients.
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Citations
Cites
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Supplementary motor area structure and function: Review and hypotheses
Goldberg, G. (1985) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00045167 · Cited by 1,233
Grafts of Fetal Dopamine Neurons Survive and Improve Motor Function in Parkinson's Disease
Lindvall, O., Brundin, P., Widner, H., Rehncrona, S., Gustavii, B., Frackowiak, R., Leenders, K. L., Sawle, G., Rothwell, J. C., Marsden, C. D., et al. (1990) · Science · doi:10.1126/science.2105529 · Cited by 1,207
Self-citationBrain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System
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Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants
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The Prevention of Acute Gastric Ulcer in the Rat by α-Methyldopa
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Self-citationDISTURBANCE OF SEQUENTIAL MOVEMENTS IN PATIENTS WITH PARKINSON'S DISEASE
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Cited by
Lindvall, O., Sawle, G., Widner, H., Rothwell, J. C., Björklund, A., Brooks, D., Brundin, P., Frackowiak, R., Marsden, C. D., Odin, P., et al. (1994) · Annals of Neurology · doi:10.1002/ana.410350208 · Cited by 451
Self-citationLong-term Evaluation of Bilateral Fetal Nigral Transplantation in Parkinson Disease
Hauser, R. A., Freeman, T. B., Snow, B. J., Nauert, M., Gauger, L., Kordower, J. H., & Olanow, C. W. (1999) · Archives of Neurology · doi:10.1001/archneur.56.2.179 · Cited by 353
Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson’s Patients with Neural Transplants
Politis, M., Wu, K., Loane, C., Quinn, N. P., Brooks, D. J., Rehncrona, S., Bjorklund, A., Lindvall, O., & Piccini, P. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000976 · Cited by 316
Self-citationLi, W., Englund, E., Widner, H., Mattsson, B., van Westen, D., Lätt, J., Rehncrona, S., Brundin, P., Björklund, A., Lindvall, O., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605245113 · Cited by 313
Self-citationKordower, J. H., Rosenstein, J. M., Collier, T. J., Burke, M. A., Chen, E.-Y., Li, J. M., Martel, L., Levey, A. E., Mufson, E. J., Freeman, T. B., et al. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960624)370:2<203::aid-cne6>3.0.co;2-6 · Cited by 313
Metadata
- Authors
- Lindvall, O., Widner, H., Rehncrona, S., Brundin, P., Odin, P., Gustavii, B., Frackowiak, R., Leenders, K. L., Sawle, G., Rothwell, J. C., Ourklund, A. B., & Marsden, C. D.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1992-02
- Volume
- 31
- Issue
- 2
- Pages
- 155-165
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2008001474
- Cited by
- 358
- References
- 30
- FWCI
- 35.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transplantation of fetal dopamine neurons in Parkinson's disease: One‐year clinical and neurophysiological observations in two patients with putaminal implants. https://app.cochat.ai/papers/10.1002/ana.410310206
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- Lindvall, O., Widner, H., Rehncrona, S., Brundin, P., Odin, P., Gustavii, B., Frackowiak, R., Leenders, K. L., Sawle, G., Rothwell, J. C., Ourklund, A. B., & Marsden, C. D. (1992). Transplantation of fetal dopamine neurons in Parkinson's disease: One‐year clinical and neurophysiological observations in two patients with putaminal implants. Annals of Neurology. https://doi.org/10.1002/ana.410310206
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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