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Cited by 285

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy

Petroff, Ognen A. C., Rothman, Douglas L., Behar, Kevin L., Lamoureux, D., Mattson, Richard H.·1996·Annals of Neurology
DOI 10.1002/ana.410390114
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Abstract

Gabapentin has come into clinical use as adjunctive therapy in the treatment of epilepsy. Designed to mimic gammaaminobutyric acid (GABA), its mechanism of action remains elusive. In vivo measurements of GABA in human brain were made using 1 H magnetic resonance spectroscopy. We used a 2.1‐T magnetic resonance imager‐spectrometer and an 8‐cm surface coil to measure a 13.5‐cm 3 volume in the occipital cortex. GABA levels were measured in 14 patients enrolled in an open‐label trial of gabapentin. GABA was elevated in patients taking gabapentin compared with 14 complex partial epilepsy patients, matched for antiepileptic drug treatment. Brain GABA levels appeared to be higher in patients taking high‐dose gabapentin (3,300–3,600 mg/day) than in those taking standard doses (1,200–2,400 mg/ day). Gabapentin appears to increase human brain GABA levels.

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Research works printed but not linked: 39

  1. 10.1111/j.1365-2125.1989.tb03454.x · DOI
  2. 10.1007/BF00966088 · DOI
  3. 10.1038/376174a0 · DOI · Paper page
  4. 10.1212/WNL.29.9_Part_1.1203 · DOI
  5. 10.1016/0920-1211(94)90012-4 · DOI
  6. Ramsay RE, 1994, Clinical efficacy and safety of gabapentin, Neurolology, 44, S23
  7. Chadwick D, 1995, Anticpileptic drugs, 851
  8. Taylor CP, 1995, Emerging perspetives on the mechanism of action of gabapentin, Neurology, 44, S10
  9. Görz F, 1993, Effects of gahapentin on release of gamma‐aminobutyric acid from slices of rar neostriatum, Arzneimittelforschung, 43, 636
  10. 10.1016/0304-3940(94)90386-7 · DOI
  11. 10.1016/0920-1211(94)00076-9 · DOI
  12. 10.1016/0140-6736(93)90754-5 · DOI · Paper page
  13. During MJ, 1994, Dynamic neurochcmical alterations in human temporal lobe epilepsy, Clin Neurosci, 2, 53
  14. 10.1073/pnas.81.20.6330 · DOI
  15. 10.1073/pnas.90.12.5662 · DOI
  16. 10.1002/mrm.1910310612 · DOI
  17. 10.1111/j.1528-1157.1995.tb00486.x · DOI
  18. 10.1111/j.1528-1157.1994.tb05963.x · DOI
  19. 10.1056/NEJM199209103271104 · DOI · Paper page
  20. 10.1002/mrm.1910320304 · DOI
  21. 10.1016/S0021-9258(18)85209-7 · DOI
  22. 10.1212/WNL.39.9.1197 · DOI
  23. Gardner MJ, 1989, Statistics with confidence
  24. 10.1016/0304-3940(91)90249-S · DOI
  25. 10.1016/0920-1211(92)90044-T · DOI
  26. Taylor CP, 1995, Antiepileptic drugs, 829
  27. Vollmer KO, 1986, Pharmacokinetics and metabolism of gabapentin in rat, dog, and man, Arzneimit‐ telforschung, 36, 830
  28. Ojemann LM, 1988, Gabapenrin concentrations in human brain, Epilepsia, 23, 694
  29. McLean MJ, 1994, Clinical pharmacokinetics of gabapenrin, Neurology, 44, S17
  30. 10.1016/0028-3908(84)90261-2 · DOI
  31. 10.1007/BF00711302 · DOI
  32. 10.1111/j.1471-4159.1993.tb03165.x · DOI · Paper page
  33. 10.1007/BF00966084 · DOI · Paper page
  34. 10.1111/j.1471-4159.1979.tb05185.x · DOI
  35. 10.1073/pnas.82.6.1633 · DOI
  36. 10.1038/jcbfm.1992.61 · DOI
  37. 10.1046/j.1471-4159.1994.63041377.x · DOI
  38. 10.1038/jcbfm.1995.2 · DOI · Paper page
  39. Manor D, 1995, Proceedings of the Society of Magnetic Resonance, 270

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Metadata

Authors
Petroff, O. A. C., Rothman, D. L., Behar, K. L., Lamoureux, D., & Mattson, R. H.
Venue
Annals of Neurology
Publisher
Wiley
Published
1996-01
Volume
39
Issue
1
Pages
95-99
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.410390114
OpenAlex
W2116471965
Cited by
285
References
1
FWCI
23.73
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3203 d)

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