The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Acute multiple sclerosis (marburg type) is associated with developmentally immature myelin basic protein
Abstract
We have studied a case of acute, fulminating multiple sclerosis (MS) (Marburg type) at the pathological and biochemical levels. Postmortem examination of the brain revealed extensive areas of gross rarefaction in the hemispheric white matter. Histologically, well‐demarcated areas of demyelination with a large influx of macrophages and a subtle perivascular infiltration of lymphocytes were seen with relative preservation of the axis cylinders. Myelin basic protein (MBP) was isolated and purifed from noninvolved white matter. It was slightly larger in molecular weight than MBP from normal brain or from chronic MS brain. The increase in mass was accounted for, in part, by the deimination of 18 of 19 arginyl residues to citrulline, making the patient's MBP much less cationic than MBP from normal white matter. When expressed as the ratio of least cationic form of MBP to the most cationic (C‐8/C‐1), the normal ratio was 0.82, chronic MS 2.5, and the patient in this study 6.7. Because the ratio of 6.7 was similar to 7.5 found for a 15‐month‐old infant, MBP was considered to be of the immature form. The data are consistent with a genetic factor influencing the charge microheterogeneity of MBP. The resulting less cationic MBP cannot carry out its normal function of compacting multilayers.
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Myelin in multiple sclerosis is developmentally immature.
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Immunology of multiple sclerosis
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PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease
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Myelin basic protein: a multifunctional protein
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Will the real multiple sclerosis please stand up?
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Retracted
Metadata
- Authors
- Wood, D. D., Moscarello, M. A., Bilbao, J. M., & O'Connors, P.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 40
- Issue
- 1
- Pages
- 18-24
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2023300261
- Cited by
- 268
- References
- 15
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acute multiple sclerosis (marburg type) is associated with developmentally immature myelin basic protein. https://app.cochat.ai/papers/10.1002/ana.410400106
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- Wood, D. D., Moscarello, M. A., Bilbao, J. M., & O'Connors, P. (1996). Acute multiple sclerosis (marburg type) is associated with developmentally immature myelin basic protein. Annals of Neurology. https://doi.org/10.1002/ana.410400106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
