The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging
Open accessAbstract
We present development and human application of a method for determining the regional cerebral density of the type 2 vesicular monoamine transporter (VMAT2) using positron emission tomography (PET) and [11 C]dihydrotetrabenazine (DTBZ). Previous animal studies indicate striatal VMAT2 density is linearly related to the integrity of substantia nigra dopamine neurons and is not subject to drug‐or lesion‐compensatory regulation. In the present studies, kinetic compartmental modeling was employed to estimate blood‐brain [11 C]DTBZ transport (K1,) and VMAT2 binding site density (tissue‐to‐plasma DTBZ distribution volume, DV)from the cerebral and plasma DTBZ time courses her intravenous tracer injection. In controls, we found reductions of putamen DTBZ DV with advancing age, corresponding to losses of 0.77% per year in specific VMAT2 binding. Parkinson's disease (PD) patients had reduction in specific DTBZ DV in the putamen (−61%) and in the caudate nucleus (−43%). There was no overlap of lowest specific putamen DTBZ DV between individual elderly controls and PD patients. The present results indicate the suitability of [11 C]DTBZ PET for objective quantification of nigrostriatal integrity, including evaluation of PD progression and its possible therapeutic modification.
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Cites
An Algorithm for Least-Squares Estimation of Nonlinear Parameters
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The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
Fahn, S., & Cohen, G. (1992) · Annals of Neurology · doi:10.1002/ana.410320616 · Cited by 927
Cited by
McCann, U. D., Wong, D. F., Yokoi, F., Villemagne, V., Dannals, R. F., & Ricaurte, G. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08417.1998 · Cited by 602
“Although agerelated reductions in the DAT are known to occur (Evans et al., 1991; Volkow et al., 1994; van Dyck et al., 1995; Frey et al., 1996), the reported age-related decreases are not of the degree observed in the present study nor do they occur from ages 30 to 37, the mean ages of…”
BackgroundInfluentialPET/SPECT imaging agents for neurodegenerative diseases
Zhu, L., Ploessl, K., & Kung, H. F. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60430f · Cited by 185
Shi, J., Zhao, L.-Y., Copersino, M. L., Fang, Y.-X., Chen, Y., Tian, J., Deng, Y., Shuai, Y., Jin, J., & Lu, L. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.042 · Cited by 108
Boileau, I., Rusjan, P., Houle, S., Wilkins, D., Tong, J., Selby, P., Guttman, M., Saint-Cyr, J. A., Wilson, A. A., & Kish, S. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3008-08.2008 · Cited by 100
Gilman, S., Koeppe, R. A., Adams, K. M., Junck, L., Kluin, K. J., Johnson‐Greene, D., Martorello, S., Heumann, M., & Bandekar, R. (1998) · Annals of Neurology · doi:10.1002/ana.410440307 · Cited by 67
Metadata
- Authors
- Frey, K. A., Koeppe, R. A., Kilbourn, M. R., Vander Borght, T. M., Albin, R. L., Gilman, S., & Kuhl, D. E.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1996-12
- Volume
- 40
- Issue
- 6
- Pages
- 873-884
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2115524468
- Cited by
- 314
- References
- 3
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Frey, K. A., Koeppe, R. A., Kilbourn, M. R., Vander Borght, T. M., Albin, R. L., Gilman, S., & Kuhl, D. E. (1996). Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging. Annals of Neurology. https://doi.org/10.1002/ana.410400609
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
