Decreased striatal monoaminergic terminals in severe chronic alcoholism demonstrated with (+)[11C]Dihydrotetrabenazine and positron emission tomography
Open accessAbstract
We used (+)[11C]dihydrotetrabenazine, a new ligand for the type 2 vesicular monoamine transporter, with positron emission tomography to study striatal monoaminergic presynaptic terminals in 7 male severe chronic alcoholic subjects without Wernicke-Korsakoff disease compared with 7 male normal controls of similar ages. We found reduced specific binding in the caudate nucleus and putamen in the alcoholic group, and the difference reached significance in the putamen. Specific binding was not decreased in the thalamus, which was examined as a reference structure. We also detected deficits in blood-to-brain transfer rate, K1, in the same regions of the alcoholic group, with a significant difference in the putamen. K1 was unchanged in the thalamus. The finding of reduced striatal VMAT2 in severe chronic alcoholic patients suggests that nigrostriatal monoaminergic terminals are reduced, with or without loss of neurons from the substantia nigra. The findings suggest that the damaging effects of severe chronic alcoholism on the central nervous system are more extensive than previously considered.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alcohol dependence is associated with reduced VMAT2 compared with controls, but not reduced [18F]DOPA uptake.
“In alcohol dependence, imaging studies show a reduction in VMAT2 compared to controls (Gilman et al., 1998) although not of [18F]DOPA uptake (Heinz et al., 2005; Tiihonen et al., 1998).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Gilman et al., 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603 · see citing works
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Drake, M. M. (1988) · American Journal of Occupational Therapy · doi:10.5014/ajot.42.10.683b · Cited by 5,303 · see citing works
The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation
Reitan, R. M., & Wolfson, D. E. (1993) · Medical Entomology and Zoology · Cited by 3,413 · see citing works
Basic Neurochemistry???Molecular, Cellular, and Medical Aspects
Long, D. M. (2006) · Neurosurgery Quarterly · doi:10.1097/01.wnq.0000203279.82150.41 · Cited by 1,288 · see citing works
Decreases in dopamine receptors but not in dopamine transporters in alcoholics
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Hitzemann, R., Ding, Y., Pappas, N., Shea, C., & Piscani, K. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb05936.x · Cited by 612 · see citing works
Cerebral circulation and metabolism
Siesjö, B. K. (1984) · Journal of neurosurgery · doi:10.3171/jns.1984.60.5.0883 · Cited by 583 · see citing works
Frontal Lobe Volume Loss Observed with Magnetic Resonance Imaging in Older Chronic Alcoholics
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., & Lim, K. O. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03798.x · Cited by 492 · see citing works
Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging
Frey, K. A., Koeppe, R. A., Kilbourn, M. R., Borght, T. M. V., Albin, R. L., Gilman, S., & Kuhl, D. E. (1996) · Annals of Neurology · doi:10.1002/ana.410400609 · Cited by 314 · see citing works
Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90134-1 · Cited by 280 · see citing works
Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence
Hietala, J., West, C., Syvälahti, E., Någren, K., Lehikoinen, P., Sonninen, P., & Ruotsalainen, U. (1994) · Psychopharmacology · doi:10.1007/bf02245330 · Cited by 269 · see citing works
Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats
Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90026-0 · Cited by 257 · see citing works
Grundlegung der Soziologie des Rechts.
Ehrlich, E. (1989) · Schriftenreihe zur Rechtssoziologie und Rechtstatsachenforschung · doi:10.3790/978-3-428-06689-6 · Cited by 255 · see citing works
Adams, K. M., Gilman, S., Koeppe, R. A., Kluin, K. J., Brunberg, J. A., Dede, D. E., Berent, S., & Kroll, P. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00750.x · Cited by 209 · see citing works
Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics
Tiihonen, J., Kuikka, J. T., Bergström, K., Hakola, P., Karhu, J., Ryynänen, O., & Föhr, J. (1995) · Nature Medicine · doi:10.1038/nm0795-654 · Cited by 208 · see citing works
The vesicular monoamine transporter is not regulated by dopaminergic drug treatments
Borght, T. V., Kilbourn, M. R., Desmond, T. J., Kuhl, D. E., & Frey, K. A. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00594-3 · Cited by 205 · see citing works
Effects of Alcohol on the Nervous System of Man
Linell, E. A. (1956) · American Journal of Psychiatry · doi:10.1176/ajp.113.6.574-a · Cited by 203 · see citing works
Recovery of brain glucose metabolism in detoxified alcoholics
Volkow, N. D., Wang, G., Hitzemann, R., Fowler, J. S., Overall, J. E., Burr, G., & Wolf, A. P. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.2.178 · Cited by 197 · see citing works
Gilman, S., Adams, K. M., Koeppe, R. A., Berent, S., Kluin, K. J., Modell, J. G., Kroll, P., & Brunberg, J. A. (1990) · Annals of Neurology · doi:10.1002/ana.410280608 · Cited by 190 · see citing works
Gongwer, M. A., Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T.-K. (1989) · Alcohol · doi:10.1016/0741-8329(89)90089-x · Cited by 179 · see citing works
Samson, H. H., Hodge, C. W., Tolliver, G. A., & Haraguchi, M. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90049-h · Cited by 176 · see citing works
A QUANTITATIVE HISTOLOGICAL STUDY OF THE CEREBELLAR VERMIS IN ALCOHOLIC PATIENTS
PHILLIPS, S. C., Harper, C. G., & Kril, J. J. (1987) · Brain · doi:10.1093/brain/110.2.301 · Cited by 170 · see citing works
Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats
McBride, W. J., Chernet, E., Dyr, W., Lumeng, L., & Li, T.-K. (1993) · Alcohol · doi:10.1016/0741-8329(93)90025-j · Cited by 160 · see citing works
Neurochemical Correlates of Cocaine and Ethanol Self‐Administrationa
Weiss, F., Hurd, Y. L., Ungerstedt, U., Markou, A., Plotsky, P. M., & Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25970.x · Cited by 151 · see citing works
Patterns of neuronal loss in the cerebral cortex in chronic alcoholic patients
Harper, C. G., & Kril, J. J. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90177-9 · Cited by 149 · see citing works
The prevalence of alcoholic cerebellar atrophy
TORVIK, A., & TORP, S. H. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90049-3 · Cited by 148 · see citing works
Neuronal counts from four cortical regions of alcoholic brains
Kril, J. J., & Harper, C. (1989) · Acta Neuropathologica · doi:10.1007/bf00294379 · Cited by 146 · see citing works
Decreased cerebral response to inhibitory neurotransmission in alcoholics
Volkow, N. D., Wang, G., Hitzemann, R., Fowler, J. S., Wolf, A. P., Pappas, N. R., Biegon, A. R., & Dewey, S. L. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.3.417 · Cited by 123 · see citing works
Harper, C., & Corbett, D. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.10.856 · Cited by 116 · see citing works
Local cerebral glucose utilisation in chronic alcoholics: a positron tomographic study.
Samson, Y., Baron, J., Féline, A., Bories, J., & Crouzel, C. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.10.1165 · Cited by 106 · see citing works
George, S. R., Fan, T., Ng, G., Jung, S., O’Dowd, B. F., & Naranjo, C. A. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09574-6 · Cited by 103 · see citing works
Gilman, S., Junck, L., Martorello, S., Lohman, M., Koeppe, R. A., Adams, K. M., Johnson-Greene, D. E., Kluin, K. J., & Brunberg, J. A. (1996) · Annals of Neurology · doi:10.1002/ana.410400207 · Cited by 103 · see citing works
Mesolimbic dopamine system in alcohol-preferring rats
Zhou, F. C., Zhang, J. K., Lumeng, L., & Li, T. (1995) · Alcohol · doi:10.1016/0741-8329(95)00010-o · Cited by 102 · see citing works
Borght, T. M. V., Sima, A. A. F., Kilbourn, M. R., Desmond, T. J., Kuhl, D. E., & Frey, K. A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00167-h · Cited by 99 · see citing works
Koeppe, R. A., Frey, K. A., Borght, T. M. V., Karlamangla, A. S., Jewett, D. M., Lee, L. C., Kilbourn, M. R., & Kuhl, D. E. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199611000-00025 · Cited by 97 · see citing works
CNS mechanisms of alcohol self-administration.
McBride, W. J., Murphy, J. M., Gj, G., Ad, L., Yoshimoto, K., Lumeng, L., & Li, T. (1993) · PubMed · Cited by 97 · see citing works
McBride, W. J., Bodart, B., Lumeng, L., & Li, T. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01001.x · Cited by 89 · see citing works
Bowden, S. (1990) · PsycEXTRA Dataset · doi:10.1037/e334482004-008 · Cited by 87 · see citing works
PAULA‐BARBOSA, M. M., BRANDÃO, F., Madeira, M. D., & Cadete-Leite, A. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb00807.x · Cited by 84 · see citing works
Halliday, G. M., ELLIS, J., HEARD, R., Caine, D., & Harper, C. G. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199311000-00003 · Cited by 75 · see citing works
Wong, D. T., Threlkeld, P. G., Lumeng, L., & Li, T. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90109-5 · Cited by 74 · see citing works
Wik, G., Borg, S., Sjögren, I., Wiesel, F. ‐., Blomqvist, G., Borg, J., Greitz, T. V. B., Nybäck, H., Sedvall, G., Stone‐Elander, S., et al. (1988) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1988.tb06330.x · Cited by 74 · see citing works
Alteration of Regional Cerebral Glucose Metabolic Rate in Non-Korsakoff Chronic Alcoholism
Sachs, H., Russell, J. A. G., Christman, D. R., & Cook, B. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520240024007 · Cited by 72 · see citing works
Decreased numbers of dendritic spines on cortical pyramidal neurons in human chronic alcoholism
Ferrer, I., Fábregues, I., Rairiz, J., & Galofré, E. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90425-8 · Cited by 69 · see citing works
Parkinsonism provoked by alcoholism
Carlen, P. L., Lee, M. A., Jacob, M., & Livshits, O. (1981) · Annals of Neurology · doi:10.1002/ana.410090117 · Cited by 59 · see citing works
Tavares, M. A., Paula‐Barbosa, M. M., & Cadete‐Leite, A. (1987) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1987.tb01315.x · Cited by 57 · see citing works
Serotonin-2 receptors in the CNS of alcohol-preferring and -nonpreferring rats
McBride, W. J., Chernet, E., Rabold, J. A., Lumeng, L., & Li, T. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90554-7 · Cited by 55 · see citing works
Computerized Tomographic Scan Assessment of Alcoholic Brain Damage and Its Potential Reversibility
Carten, P. L., Penn, R. D., Fomazzari, L., Bennett, J., Wilkinson, D. A., & Wortzman, G. (1986) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1986.tb05080.x · Cited by 55 · see citing works
Naudon, L., Leroux‐Nicollet, I., & Costentin, J. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90136-8 · Cited by 54 · see citing works
Fewer pigmented neurons in the locus coeruleus of uncomplicated alcoholics
Arango, V., Underwood, M. D., & Mann, J. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)90199-6 · Cited by 54 · see citing works
Altered dopamine transporter densities in alcohol-preferring vervet monkeys
Mash, D. C., Staley, J. K., Fm, D., Young, S. N., Ervin, F. R., & Palmour, R. M. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00020 · Cited by 53 · see citing works
If you drink your brain will shrink. Neuropathological considerations.
Harper, C., & Kril, J. J. (1991) · PubMed · Cited by 52 · see citing works
McBride, W. J., Chernet, E., Russell, R., Wong, D. T., Guan, X.-M., Lumeng, L., & Li, T. (1997) · Alcohol · doi:10.1016/s0741-8329(96)00117-6 · Cited by 52 · see citing works
Effects of chronic alcohol intake and withdrawal on the prefrontal neurons and synapses
Cadete-Leite, A., Alves, M. C. D. Q., Tavares, M. A., & Paula-Barbosa, M. M. (1990) · Alcohol · doi:10.1016/0741-8329(90)90076-o · Cited by 46 · see citing works
Adams, K. M., Gilman, S., Koeppe, R. A., Kluin, K. J., Junck, L., Lohman, M., Johnson-Greene, D. E., Berent, S., Dede, D. E., & Kroll, P. (1995) · Neuropsychology · doi:10.1037/0894-4105.9.3.275 · Cited by 44 · see citing works
Neuroendocrine Evidence for Reduced Serotonergic Neurotransmission During Heavy Drinking
Balldin, J., Berggren, U., Engel, J. A., & Eriksson, M. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00045.x · Cited by 42 · see citing works
Halliday, G. M., Ellis, J., & Harper, C. G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90164-5 · Cited by 39 · see citing works
Kish, S. J., Robitaille, Y., El‐Awar, M., Clark, B., Schut, L. J., Ball, M. J., Young, L. T., Currier, R. D., & Shannak, K. S. (1992) · Neurology · doi:10.1212/wnl.42.8.1573 · Cited by 38 · see citing works
Serotonin and alcohol-related brain damage
Halliday, G. M., Baker, K. G., & Harper, C. G. (1995) · Metabolic Brain Disease · doi:10.1007/bf01991780 · Cited by 37 · see citing works
Baker, K. G., Halliday, G. M., Kril, J. J., & Harper, C. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01045.x · Cited by 33 · see citing works
Andrade, J. P., Fernando, P. M., Madeira, M. D., Paula‐Barbosa, M. M., Cadete-Leite, A., & Zimmer, J. (1992) · Hippocampus · doi:10.1002/hipo.450020109 · Cited by 30 · see citing works
Cadete-Leite, A., Alves, M. C. D. Q., PAULA-BARBOSA, M. M., Uylings, H. B. M., & TAVARES, M. A. (1990) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045039 · Cited by 29 · see citing works
ALTERATIONS IN SEROTONIN RECEPTOR SUBTYPES IN ETHANOL-DEPENDENT RATS
Ulrichsen, J. (1991) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045160 · Cited by 29 · see citing works
Effect of Chronic Alcohol Consumption on the Human Locus Coeruleus
Baker, K. G., Halliday, G. M., & Harper, C. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb01455.x · Cited by 28 · see citing works
Effects of phencyclidine and ketamine on punished and unpunished responding by pigeons
Chait, L. D., Wenger, G. R., & McMillan, D. E. (1981) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(81)90354-3 · Cited by 23 · see citing works
Cross-study comparisons of self-reported alcohol consumption in four clinical groups
Adams, K. M., Grant, I., Carlin, A. S., & Reed, R. J. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.4.445 · Cited by 23 · see citing works
Dangerousness of the Mentally Ill?
ADAMS, J. J. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.6.857-b · Cited by 11 · see citing works
NORADRENERGIC LOCUS COERULEUS NEURONS
Halliday, G. M., & Baker, K. G. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01064.x · Cited by 5 · see citing works
Gilman, S., Arbor, A., & Quinn, N. P. (1997) · Neurology · doi:10.1212/wnl.48.3.791 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 9
- Weiss F, Hurd E, Ungerstedt U, et al. Neurochemical corre- lates of cocaine and ethanol self-administration. Ann NY Acad Sci 1992;654:220-24 1
- McBride WJ, Chernet E, Dyr W, er al. Densities of D, recep- tors are reduced in CNS regions of alcohol-preferring P rats. Alcohol 1993; 10:387-390
- Naudon L, Leroux-Nicollet I, Costentin J. Short-term treat- ments with haloperidol or bromocriptine do not alter the den- sity of the monoamine vesicular transporter. Neurosci Lett 1994; 173: 1-4 598~33-37
- Gilman S, Koeppe RA, Junck L, et al. Decreased striatal mono- aminergic terminals in severe chronic alcoholism detected with (+)[I 'Cldihydrotetrabenazine and positron emission tomogra- phy. Neurology 1997;48:A275 (Abstract)
- Wesson D, Carlin A, A d a m KM, Beschner G. Polydrug abuse. New York: Academic Press, 1978
- Koeppe RA, Frey KA, Vander Borght TM, et al. Kinetic eval- uarion of ["C]dihydrotecrabenazine by dynamic PET: measure- ment of vesicular monoamine transporter. J Cereb Blood Flow Metab 1996; 16: 1288-1299
- Tiihonen J, Kuikka J, Bergstrom K, et al. Altered sttiatal do- pamine re-uptake site densities in habitual violent and non- violent alcoholics. Nat Med 1995;1:654-657
- Siesjo BK. Cerebral circulation and merabolism. J Neurosurg 1984;60:883-908
- Carlen PL, Lee MA, Jacob M, Livshits 0. Parkinsonism pro- voked by alcoholism. Ann Neurol 1981;9:84-86 1995;68:955-962
Cited by
Sorted by citations
Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
Martinez, D., Gil, R., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Kegeles, L., Talbot, P., Evans, S., Krystal, J., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.044 · Cited by 445 · see citing works
Dopamine and alcoholism: neurobiological basis of ethanol abuse.
Tupala, E., & Tiihonen, J. (2004) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.06.022 · Cited by 209 · see citing works
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
Kamal, H., Tan, G. C., Ibrahim, S. F., Shaikh, M. F., Mohamed, I. N., Mohamed, R. M. P., Hamid, A. A., Ugusman, A., & Kumar, J. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00282 · Cited by 164 · see citing works
Alcohol Misuse and Mood Disorders Following Traumatic Brain Injury
Jorge, R. E., STARKSTEIN, S. E., Arndt, S. V., Moser, D. J., Crespo‐Facorro, B., & Robinson, R. G. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.742 · Cited by 165 · see citing works
Pathophysiologic Aspects of Major Depression Following Traumatic Brain Injury
Jorge, R. E., & STARKSTEIN, S. E. (2005) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200511000-00001 · Cited by 142 · see citing works
Correlation of Parkinson Disease Severity and18F-DTBZ Positron Emission Tomography
Hsiao, I., Weng, Y.-H., Hsieh, C., Lin, W., Wey, S., Kung, M., Yen, T., Lu, C., & Lin, K. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.290 · Cited by 118 · see citing works
Volkow, N. D., Wiers, C. E., Kojori, E. S., Tomasi, D. G., Wang, G., & Baler, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.012 · Cited by 105 · see citing works
Dopamine transporter and D 2 -receptor density in late-onset alcoholism
Repo, E., Kuikka, J. T., Bergström, K. A., Karhu, J., Hiltunen, J., Tiihonen, J., & Kuikka, J. T. (1999) · Psychopharmacology · doi:10.1007/s002130051173 · Cited by 96 · see citing works
Volkow, N., Fowler, J., & Wang, G.-J. (2003) · Seminars in nuclear medicine · doi:10.1053/snuc.2003.127300 · Cited by 89 · see citing works
Gorwood, P. A. P. M., Limosin, F., Batel, P., Hamon, M., Adès, J., & Boni, C. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01440-3 · Cited by 89 · see citing works
O’Keeffe, G. W., & Sullivan, A. M. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2018.06.025 · Cited by 84 · see citing works
Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders
Verhoeff, N. (1999) · Psychopharmacology · doi:10.1007/s002130051163 · Cited by 79 · see citing works
Brain Dopamine Transporter Messenger RNA and Binding Sites in Cocaine Users
Little, K. Y., McLaughlin, D. P., Zhang, L., McFinton, P. R., Dalack, G. W., Cook, E. H., Cassin, B. J., & Watson, S. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.9.793 · Cited by 76 · see citing works
Prefrontal cortical dopamine transmission is decreased in alcoholism
Narendran, R., Mason, N., Paris, J., Himes, M. L., Douaihy, A., & Frankle, W. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13121581 · Cited by 69 · see citing works
Eriksson, A.-K., Löfving, S., Callaghan, R. C., & Allebeck, P. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-190 · Cited by 60 · see citing works
Sala, G., Brighina, L., Saracchi, E., Fermi, S., Riva, C., Carrozza, V., Pirovano, M., & Ferrarese, C. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0446-z · Cited by 60 · see citing works
In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter
Efange, S. M. N. (2000) · The FASEB Journal · doi:10.1096/fj.00-0204rev · Cited by 60 · see citing works
Lin, Z., Canales, J. J., Björgvinsson, Þ., Thomsen, M., Qu, H., Liu, Q., Torres, G. E., & Caine, S. B. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00001-6 · Cited by 57 · see citing works
Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior.
Trifilieff, P., Ducrocq, F., van der Veldt, S., & Martinez, D. (2017) · Seminars in nuclear medicine · doi:10.1053/j.semnuclmed.2016.09.003 · Cited by 47 · see citing works
In Vivo Measurement of the Vesicular Monoamine Transporter in Schizophrenia
Taylor, S., Koeppe, R., Tandon, R., Zubieta, J., & Frey, K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00165-2 · Cited by 55 · see citing works
Madrazo, I., Kopyov, O. V., Ávila‐Rodríguez, M. A., Ostrosky, F., Carrasco, H., Kopyov, O. V., Avendaño‐Estrada, A., Jiménez, F., Magallón, E., Zamorano, C., et al. (2018) · Cell Transplantation · doi:10.1177/0963689718820271 · Cited by 53 · see citing works
Smoking is associated with neurocognitive deficits in alcoholism☆
Glass, J. M., Adams, K. M., Nigg, J. T., Wong, M. M.-H., Puttler, L. I., Buu, A., Jester, J. M., Fitzgerald, H. E., & Zucker, R. A. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.08.013 · Cited by 53 · see citing works
Imaging neurotransmitter release by drugs of abuse.
Martinez, D., & Narendran, R. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_34 · Cited by 42 · see citing works
Imaging the Neurochemistry of Alcohol and Substance Abuse
Martínez, D., Kim, J., Krystal, J. H., & Abi‐Dargham, A. (2007) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2007.07.004 · Cited by 49 · see citing works
Blum, K., Chen, T. J. H., Meshkin, B., Waite, R. L., Downs, B. W., Blum, S. H., Mengucci, J. F., Arcuri, V., Braverman, E. R., & Palomo, T. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.12.062 · Cited by 49 · see citing works
Tupala, E., Hall, H., Bergström, K., Mantere, T., Räsänen, P. K., Särkioja, T., & Tiihonen, J. (2003) · Human Brain Mapping · doi:10.1002/hbm.10129 · Cited by 45 · see citing works
Graff, L., Castrop, F., Bauer, M., Höfler, H., & Gratzl, M. (2001) · PubMed · Cited by 38 · see citing works
Tong, J., Boileau, I., Furukawa, Y., Chang, L., Wilson, A. A., Houle, S., & Kish, S. J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.63 · Cited by 33 · see citing works
Akine, Y., Kato, M., Muramatsu, T., Umeda, S., Mimura, M., Asai, Y., Tanada, S., Obata, T., Ikehira, H., Kashima, H., et al. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00453.x · Cited by 33 · see citing works
Mittleman, G., Call, S. B., Cockroft, J. L., Goldowitz, D., Matthews, D. B., & Blaha, C. D. (2011) · Alcohol · doi:10.1016/j.alcohol.2010.12.006 · Cited by 33 · see citing works
Lin, K., Weng, Y.-H., Hsieh, C., Lin, W., Wey, S., Kung, M., Yen, T., Lu, C., & Hsiao, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075952 · Cited by 32 · see citing works
Hillmer, A. T., Mason, G. F., Fucito, L. M., O’Malley, S. S., & Cosgrove, K. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12893 · Cited by 30 · see citing works
Lawrence, A. D., & Brooks, D. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00086 · Cited by 29 · see citing works
Positron emission tomography in psychiatric disorders
Newberg, A. B., Moss, A., Monti, D., & Alavi, A. A. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06162.x · Cited by 27 · see citing works
Tupala, E., Hall, H., Bergström, K., Mantere, T., Räsänen, P. K., Särkioja, T., Hiltunen, J. O., & Tiihonen, J. (2003) · Synapse · doi:10.1002/syn.10206 · Cited by 26 · see citing works
Molecular imaging in alcohol dependence
Ravan, S., Martínez, D., Slifstein, M., & Abi‐Dargham, A. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00018-5 · Cited by 21 · see citing works
Alcoholism and Cellular Vulnerability in Different Brain Regions
Skuja, S., Groma, V., & Smane, L. (2012) · Ultrastructural Pathology · doi:10.3109/01913123.2011.629770 · Cited by 18 · see citing works
Positron emission tomography as a tool for studying alcohol abuse.
Thanos, P. K., Wang, G., & Volkow, N. D. (2008) · Europe PMC (PubMed Central) · Cited by 18 · see citing works
Jorge, R. E. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63521-1.00038-8 · Cited by 16 · see citing works
Lung, H. J., Weng, Y.-H., Wen, M., Hsiao, I., & Lin, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-34388-6 · Cited by 15 · see citing works
Increased Turnover of Dopamine in Caudate Nucleus of Detoxified Alcoholic Patients
Kumakura, Y., GJEDDE, A. H., Caprioli, D., Kienast, T., Beck, A., Plotkin, M., Schlagenhauf, F., Vernaleken, I., Gründer, G., Bartenstein, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073903 · Cited by 14 · see citing works
Pan, Y., Liu, S., Zeng, Y., Ye, C., Qiao, H., Song, T., Lv, H., Chan, P., Lu, J., & Ma, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.902169 · Cited by 7 · see citing works
Role of PET in the Investigation of Neuropsychiatric Disorders
Newberg, A. B., & Alavi, A. A. (2010) · PET Clinics · doi:10.1016/j.cpet.2010.03.003 · Cited by 7 · see citing works
Tupala, E., Häkkinen, M. R., Storvik, M., & Tiihonen, J. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.12.001 · Cited by 6 · see citing works
Neuronal and psychological underpinnings of pathological gambling
Singer, B. F., Anselme, P., Robinson, M. J., & Vezina, P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00230 · Cited by 8 · see citing works
Mechanisms of Storage and Exocytosis in Neuroendocrine Tumors
Gratzl, M., Breckner, M., & Prinz, C. (2004) · Endocrine Pathology · doi:10.1385/ep:15:1:01 · Cited by 6 · see citing works
Chohan, M. O., Fein, H., Mirro, S., O’Reilly, K. C., & Veenstra-VanderWeele, J. M. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06448-x · Cited by 5 · see citing works
Neuroimaging and mechanisms of drug abuse: interface of molecular imaging and molecular genetics
Monique Ernst, D., Kimes, A. S., & Jazbec, S. (2003) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(03)00109-6 · Cited by 5 · see citing works
Positron emission tomography in neurological and psychiatric disorders
Newberg, A., Monti, D. A., Moss, A., & Alavi, A. (2012) · International journal of imaging systems and technology (Print) · doi:10.1002/ima.22004 · Cited by 3 · see citing works
Exposure to disulfiram and incidence of parkinsonism
d’Errico, A., Strippoli, E., Goldman, S. M., & Blanc, P. D. (2025) · Journal of Occupational Medicine and Toxicology · doi:10.1186/s12995-025-00454-9 · Cited by 4 · see citing works
Neurochemical Imaging of Addictive Disorders
Broft, A. I., & Martínez, D. (2012) · Neuromethods · doi:10.1007/7657_2012_48 · Cited by 4 · see citing works
Abnormalities of Neurotransmission in Drug Addiction
Trick, L., Butler, K., Chukwueke, C. C., Ciano, P. D., Ibrahim, C., Rubin-Kahana, D. S., Boileau, I., & Foll, B. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_21 · Cited by 4 · see citing works
Emission Tomographic Studies in Substance Abuse
Levin, J. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-021-6_5 · Cited by 4 · see citing works
Kaur, J., Sandhu, R. K., Kubra, K. T., Benitez, J. S. C., Onyeaka, H., Akter, S., & Williams, O. C. A. (2021) · Cureus · doi:10.7759/cureus.16033 · Cited by 2 · see citing works
Blum, K., Simpatico, T. A., Waite, R. L., Blum, S. H., Dushaj, K., Madigan, M. A., Braverman, E. R., & Oscar‐Berman, M. (2014) · Health · doi:10.4236/health.2014.616262 · Cited by 1 · see citing works
Neurochemical Imaging in Addiction
Wai, J. M., LEVIN, F. R., & Martínez, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54856-4.00001-8 · Cited by 1 · see citing works
Imaging the Brain Dopamine Transporter Using PET and SPECT
Gatley, S. J., Volkow, N. D., Fowler, J. S., Ding, Y., Logan, J., Wang, G., Felder, C. A., Telang, F., & Gifford, A. N. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-158-9_12 · Cited by 1 · see citing works
Imaging as Means to Study Cerebrovascular Pathophysiology
Brennan, C., Janigro, D., Achey, R. L., & Wathen, C. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00139-1
The Relationship of Alcohol Dependence to Monoamine Oxidase A
Matthews, B. A. (2015) · TSpace (University of Toronto)
Gamma camera imaging in psychiatric disorders
Bal, C. S., & Chakraborthy, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822960-6.00222-2
Molecular Neuroimaging in Addictive Disorders
London, E. D., & Robertson, C. L. (2017) · doi:10.1093/med/9780190681425.003.0045
Patel, V., & Pandey, A. K. (2023) · International Conference on Artificial Intelligence and Smart Communication (AISC) · doi:10.1109/aisc56616.2023.10085140
Haseeb, A., Ahmad, Q. T., Basit, A., Samad, M., & Afridi, A. (2025) · Cureus · doi:10.7759/cureus.93923
Ferrando, R. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1798789
- Authors
- Gilman, S., Koeppe, R. A., Adams, K. M., Junck, L., Kluin, K. J., Johnson‐Greene, D., Martorello, S., Heumann, M., & Bandekar, R.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Gilman, Sid
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1998-09
- Volume
- 44
- Issue
- 3
- Pages
- 326-333
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2028039657
- Cited by
- 67
- References
- 69
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- University of Michigan
- National Institute on Alcohol Abuse and Alcoholism (AA 07378, P50AA007378)
- National Institute on Aging (AG 08671, P50AG008671)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- chronic alcoholism, vesicular monoamine transporter 2, dihydrotetrabenazine, caudate nucleus, putamen, nigrostriatal pathway, substantia nigra
- MeSH terms
- Adult, Aged, Alcoholism, Corpus Striatum, Humans, Injections, Intravenous, Male, Membrane Glycoproteins, Middle Aged, Nerve Endings, Neuropeptides, Smoking, Tetrabenazine, Tomography, Emission-Computed, Biogenic Monoamines, Cohort Studies, Neurotransmitter Agents, Membrane Transport Proteins, Vesicular Biogenic Amine Transport Proteins, Vesicular Monoamine Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review