Cited by 67Neurotransmitter Receptor Influence on BehaviorAlcoholism and Thiamine DeficiencyParkinson's Disease Mechanisms and Treatments

Decreased striatal monoaminergic terminals in severe chronic alcoholism demonstrated with (+)[11C]Dihydrotetrabenazine and positron emission tomography

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Gilman, Sid, Koeppe, Robert A., Adams, Kenneth M., Junck, Larry, Kluin, Karen J., Johnson‐Greene, Doug, Martorello, Susan, Heumann, Mary +1 more·1998·Annals of Neurology

Abstract

We used (+)[11C]dihydrotetrabenazine, a new ligand for the type 2 vesicular monoamine transporter, with positron emission tomography to study striatal monoaminergic presynaptic terminals in 7 male severe chronic alcoholic subjects without Wernicke-Korsakoff disease compared with 7 male normal controls of similar ages. We found reduced specific binding in the caudate nucleus and putamen in the alcoholic group, and the difference reached significance in the putamen. Specific binding was not decreased in the thalamus, which was examined as a reference structure. We also detected deficits in blood-to-brain transfer rate, K1, in the same regions of the alcoholic group, with a significant difference in the putamen. K1 was unchanged in the thalamus. The finding of reduced striatal VMAT2 in severe chronic alcoholic patients suggests that nigrostriatal monoaminergic terminals are reduced, with or without loss of neurons from the substantia nigra. The findings suggest that the damaging effects of severe chronic alcoholism on the central nervous system are more extensive than previously considered.

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Authors
Gilman, S., Koeppe, R. A., Adams, K. M., Junck, L., Kluin, K. J., Johnson‐Greene, D., Martorello, S., Heumann, M., & Bandekar, R.
Affiliations
University of Michigan (US)
Corresponding author
Gilman, Sid
Venue
Annals of Neurology
Publisher
Wiley
Published
1998-09
Volume
44
Issue
3
Pages
326-333
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2028039657
Cited by
67
References
69
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 3
FWCI
0.92
Type
journal article
Language
en
Open access
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
  • University of Michigan
  • National Institute on Alcohol Abuse and Alcoholism (AA 07378, P50AA007378)
  • National Institute on Aging (AG 08671, P50AG008671)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
chronic alcoholism, vesicular monoamine transporter 2, dihydrotetrabenazine, caudate nucleus, putamen, nigrostriatal pathway, substantia nigra
MeSH terms
Adult, Aged, Alcoholism, Corpus Striatum, Humans, Injections, Intravenous, Male, Membrane Glycoproteins, Middle Aged, Nerve Endings, Neuropeptides, Smoking, Tetrabenazine, Tomography, Emission-Computed, Biogenic Monoamines, Cohort Studies, Neurotransmitter Agents, Membrane Transport Proteins, Vesicular Biogenic Amine Transport Proteins, Vesicular Monoamine Transport Proteins

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