The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Open accessAbstract
This study investigated cerebral glucose metabolism in very early Alzheimer's disease, before a clinical diagnosis of probable Alzheimer's disease is possible, using [18 F]fluorodeoxyglucose positron emission tomography. First, 66 patients with probable Alzheimer's disease with a spectrum of dementia severity (Mini‐Mental State Examination score, 0–23) were recruited and studied. Cortical metabolic activity was analyzed topographically using three‐dimensional stereotactic surface projections. Regression analysis was performed for each brain pixel to predict metabolic patterns of very early disease. Predictions were tested prospectively in a group of 8 patients who complained only of memory impairment without general cognitive decline (Mini‐Mental State Examination score, 25 · 1) at the time of scanning but whose condition later progressed to probable Alzheimer's disease. Both results were compared to cerebral metabolic activity in 22 age‐similar normal control subjects. Prediction and analysis of actual patients consistently indicated marked metabolic reduction (21–22%) in the posterior cingulate cortex and cinguloparietal transitional area in patients with very early Alzheimer's disease. Mean metabolic reduction in the posterior cingulate cortex was significantly greater than that in the lateral neocortices or parahippocampal cortex. The result suggests a functional importance for the posterior cingulate cortex in impairment of learning and memory, which is a feature of very early Alzheimer's disease.
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“Compelling evidence links neurodegeneration to altered brain metabolism and mitochondrial dysfunction, both of which are early hallmarks of AD [21–28].”
From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [21]
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“Instead, in the very early phases of AD, a significant loss of σ1R occurs in the brain [115,116].”
From Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies (2023) · cites this paper as [116]
Experimental — accuracy not yet measuredIn the citing paper
“The precuneus region, which is known to be an area of early deposition in both sporadic Alzheimer’s disease and autosomal dominant Alzheimer’s disease,4,23,24 was chosen for analysis of amyloid deposition.”
From Clinical and biomarker changes in dominantly inherited Alzheimer's disease (2012) · cites this paper as [23]
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“Finally, we note the selective vulnerability of the posterior cingulate and precuneus in such conditions as carbon monoxide poisoning [i.e., acute hypoxia (34)], diffuse brain ischemia (35), and Alzheimer's disease (32).”
From A default mode of brain function (2001) · cites this paper as [32]
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“Furthermore, patients with Alzheimer's disease show early reductions of metabolic activity in this area (32) and have been reported to show abnormalities in the processing of extrafoveal information (33).”
From A default mode of brain function (2001) · cites this paper as [32]
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Cited by
Sorted by citations
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
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Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
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Metadata
- Authors
- Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E.
- Affiliations
- University of Michigan (US)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1997-07
- Volume
- 42
- Issue
- 1
- Pages
- 85-94
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2144631174
- Cited by
- 1,802
- References
- 68
- Citations by year
- 2026: 45 · 2025: 53 · 2024: 38 · 2023: 41 · 2022: 42 · 2021: 65 · 2020: 67 · 2019: 62 · 2018: 61 · 2017: 74 · 2016: 83 · 2015: 81 · 2014: 93 · 2013: 76 · 2012: 66
- FWCI
- 17.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- U.S. Department of Energy (DE‐FG02‐)
- University of Michigan
- National Institutes of Health (5r01ns024896-15, 1p30ag008808-01)
- National Institute on Aging (P50AG008671, P30 AG08808, P50 AG08671)
- National Institute of Neurological Disorders and Stroke (R01 NS24896)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, posterior cingulate cortex, brain glucose metabolism, FDG-PET, memory impairment, dementia severity, disease progression prediction, learning and memory
- MeSH terms
- Aged, Alzheimer Disease, Cognition, Deoxyglucose, Energy Metabolism, Female, Glucose, Gyrus Cinguli, Humans, Male, Memory, Prospective Studies, Psychiatric Status Rating Scales, Stereotaxic Techniques, Time Factors, Tissue Distribution, Tomography, Emission-Computed, Radiopharmaceuticals, Fluorodeoxyglucose F18
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