The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination
Abstract
We describe a case of multiple sclerosis characterized by deposition of immunoglobulin and complement in the areas of active demyelination. This was particularly evident for the C9neo antigen, which is a marker for the activated lytic complement complex and was exclusively deposited in the areas of active myelin destruction. In addition, macrophages in the lesions contained degradation products that were immunoreactive for myelin antigens, immunoglobulins, and C9neo antigen. Destruction of myelin sheaths was associated with incomplete loss of oligodendrocytes in the active areas and reappearance of oligodendrocytes with remyelination in the inactive plaque center.
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Citations
Cites
Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
Selmaj, K. W., & Raine, C. S. (1988) · Annals of Neurology · doi:10.1002/ana.410230405 · Cited by 1,368
Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis
Lucchinetti, C. F., Brück, W., Rodriguez, M., & Lassmann, H. (1996) · Brain Pathology · doi:10.1111/j.1750-3639.1996.tb00854.x · Cited by 733
Self-citationMonocyte/macrophage differentiation in early multiple sclerosis lesions
Brück, W., Porada, P., Poser, S., Rieckmann, P., Hanefeld, F., Kretzschmarch, H. A., & Lassmann, H. (1995) · Annals of Neurology · doi:10.1002/ana.410380514 · Cited by 530
Self-citationBrunner, C., Lassmann, H., Waehneldt, T. V., Matthieu, J., & Linington, C. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb10930.x · Cited by 409
Self-citationPatterns of oligodendroglia pathology in multiple sclerosis
Ozawa, K., Suchanek, G., Breitschopf, H., Br€ck, W., Budka, H., Jellinger, K., & Lassmann, H. (1994) · Brain · doi:10.1093/brain/117.6.1311 · Cited by 404
Self-citationT and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis
Sun, J., Link, H., Olsson, T., Xiao, B. G., Andersson, G., Ekre, H. P., Linington, C., & Diener, P. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.5.1490 · Cited by 315
Piddlesden, S. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90424-6 · Cited by 287
Self-citationSelmaj, K., Brosnan, C. F., & Raine, C. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6452 · Cited by 283
Gold, R., Schmied, M., Rothe, G., Zischler, H., Breitschopf, H., Wekerle, H., & Lassmann, H. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.7.8515045 · Cited by 270
Self-citationMultiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown
Prineas, J. W., & Graham, J. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100205 · Cited by 264
Cited by
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149
Immunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis
Hauser, S. L., Bar-Or, A., Comi, G., Giovannoni, G., Hartung, H.-P., Hemmer, B., Lublin, F., Montalban, X., Rammohan, K. W., Selmaj, K., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1601277 · Cited by 2,021
Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
Montalban, X., Hauser, S. L., Kappos, L., Arnold, D. L., Bar-Or, A., Comi, G., de Seze, J., Giovannoni, G., Hartung, H.-P., Hemmer, B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606468 · Cited by 1,905
Magliozzi, R., Howell, O., Vora, A., Serafini, B., Nicholas, R., Puopolo, M., Reynolds, R., & Aloisi, F. (2006) · Brain · doi:10.1093/brain/awm038 · Cited by 1,443
Metadata
- Authors
- Storch, M. K., Piddlesden, S., Haltia, M., Iivanainen, M., Morgan, P., & Lassmann, H.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1998-04
- Volume
- 43
- Issue
- 4
- Pages
- 465-471
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2137350492
- Cited by
- 422
- References
- 29
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination. https://app.cochat.ai/papers/10.1002/ana.410430409
- The paper
- Storch, M. K., Piddlesden, S., Haltia, M., Iivanainen, M., Morgan, P., & Lassmann, H. (1998). Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination. Annals of Neurology. https://doi.org/10.1002/ana.410430409
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
