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Cited by 266Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease

Reiman, Eric M., Uecker, Anne, Caselli, Richard J., Lewis, Stephen, Bandy, Daniel, De Leon, Mony J., De Santi, Susan, Convit, Antonio, Osborne, David, Weaver, Amy, Thibodeau, Stephen N.·1998·Annals of Neurology
DOI 10.1002/ana.410440226
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Abstract

Brain imaging techniques have the potential to characterize neurobiological changes that precede the onset of cognitive impairment in persons at risk for Alzheimer's disease. As previously described, positron emission tomography (PET) was used to compare 11 cognitively normal persons 50 to 62 years of age who were homozygous for the ε4 allele of apolipoprotein E and 22 persons without the ε4 allele with a reported family history of Alzheimer's dementia who were matched for sex, age, and level of education. The ε4 homozygotes had significantly reduced glucose metabolism in the same brain regions as patients with Alzheimer's dementia; the largest reduction was in the posterior cingulate cortex. As described here, magnetic resonance imaging (MRI) was used to compare hippocampal volumes in the same subject groups. The ε4 homozygotes showed nonsignificant trends for smaller left and right hippocampal volumes; overall, smaller hippocampal volumes were associated with reduced performance on a long‐term memory test. Whereas PET measurements of cerebral glucose metabolism begin to decrease before the onset of memory decline, MRI measurements of hippocampal volume begin to decrease in conjunction with memory decline in cognitively normal persons at risk for Alzheimer's disease.

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Crossref · 10.1002/ana.410440226

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Research works printed but not linked: 1

  1. Tsui WT, 1995, Multimodal image data analysis system (MIDAS), version 1.0

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Metadata

Authors
Reiman, E. M., Uecker, A., Caselli, R. J., Lewis, S., Bandy, D., De Leon, M. J., De Santi, S., Convit, A., Osborne, D., Weaver, A., & Thibodeau, S. N.
Affiliations
  • University of Arizona (US)
  • Mayo Clinic (US)
  • Good Samaritan Regional Medical Center (US)
  • NYU Langone Health (US)
Corresponding author
Reiman, Eric M.
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
1998-08
Volume
44
Issue
2
Pages
288-291
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.410440226
OpenAlex
W1996433268
Cited by
266
References
19
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 14 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 15 · 2013: 7 · 2012: 13
FWCI
9.36
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2260 d)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG 12101, R01AG013616, AG 13616)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords
hippocampal volume, Alzheimer's disease, APOE ε4, genetic risk, cognitively normal elderly, family history of dementia, brain glucose metabolism, posterior cingulate cortex, long-term memory, hippocampal atrophy, early detection of cognitive decline
MeSH terms
Aged, Alleles, Alzheimer Disease, Apolipoproteins E, Carrier State, Genotype, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Middle Aged, Neuropsychological Tests, Reference Values, Sensitivity and Specificity, Chi-Square Distribution, Logistic Models

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