Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease
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Our goal was to ascertain the involvement of the temporal lobe in the preclinical (not yet diagnosable) stages of dementia of the Alzheimer's type (DAT) by using MRI-derived volumes. We assessed anatomical subdivisions of the temporal lobe on three groups of carefully screened age- and education-matched elderly individuals: 27 normal elderly (NL), 22 individuals with minimal cognitive impairment (MCI), who did not fulfill DAT criteria but were regarded at high risk for future DAT, and 27 DAT individuals. We found hippocampal volume reductions of 14% for the MCI and 22% for the DAT group compared to the NL group. Utilizing regression analyses and after accounting for gender head size-age, generalized atrophy (CSF), and other temporal lobe subvolumes, the hippocampal volume separated NL from MCI individuals, correctly classifying 74%. For NL and MCI groups combined the hippocampal volume was the only temporal lobe subvolume related to delayed recall memory performance. When contrasting MCI and DAT individuals, the fusiform gyrus volume uniquely improved the ability of the hippocampal volume to separate MCI from DAT individuals from 74 to 80%. Our cross-sectional data suggest that, within the temporal lobe, specific hippocampal volume reductions separated the group at risk for DAT from the normal group. By the time impairments are sufficient to allow a diagnosis of DAT to be made, in addition to the medial temporal lobe volume reductions, the lateral temporal lobe is also showing volume reductions, most saliently involving the fusiform gyrus.
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The hippocampus and other brain volumes were measured by using validated methods on standardized MRIs.
“The hippocampus and other brain volumes were measured by using validated methods on standardized MRIs.”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [25]
Evidence suggesting hippocampal volume reductions in MCI may characterize a clinical-anatomical stage preceding dementia and neocortical atrophy comes only from cross-sectional data.
“Evidence suggesting that hippocampal volume reductions in MCI may characterize a clinical-anatomical stage that precedes dementia and neocortical atrophy comes only from cross-sectional data (8).”
Hippocampal atrophy is detectable prior to the diagnosis of Alzheimer's disease, at the stage of amnestic Mild Cognitive Impairment or earlier in asymptomatic elderly.
“Using MRI, this atrophy is detectable prior to the diagnosis of AD, at the stage of amnestic Mild Cognitive Impairment (aMCI) (Convit et al., 1997; Shi et al., 2009) or even earlier, in asymptomatic elderly up to 10 years before the diagnosis of dementia (Smith et al., 2007; Tondelli et al., 2012).”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Convit et al., 1997
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McIntyre, R. S., Kenna, H. A., Nguyen, H. T., Law, C. W. Y., Sultan, F., Woldeyohannes, H. O., Alsuwaidan, M. T., Soczynska, J. K., Adams, A. K., Cheng, J. S. H., et al. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0011-z · Cited by 83 · see citing works
Magnetic resonance and PET studies in the early diagnosis of Alzheimer’s disease
Mosconi, L., De Santi, S., Rusinek, H., Convit, A., & de Leon, M. J. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.5.831 · Cited by 46 · see citing works
Self-citationThe association between white matter hyperintensities and amyloid and tau deposition
Alban, S. L., Lynch, K. M., Ringman, J. M., Toga, A. W., Chui, H. C., Sepehrband, F., & Choupan, J. (2023) · NeuroImage: Clinical · doi:10.1016/j.nicl.2023.103383 · Cited by 35 · see citing works
Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?
McIntyre, R. S., Soczynska, J. K., Woldeyohannes, H. O., Lewis, G. F., Leiter, L. A., MacQueen, G. M., Miranda, A., Fulgosi, D., Konarski, J. Z., & Kennedy, S. H. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.11.1615 · Cited by 32 · see citing works
Dang, M., Yang, C., Chen, K., Lu, P., Li, H., Zhang, Z., & for the Beijing Aging Brain Rejuvenation Initiative, F. T. A. D. N. I. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01167-z · Cited by 16 · see citing works
“In the past, we tended to focus on the hippocampus during the development of cognitive impairment [48, 49], but the current study suggests that we also need to consider the synchronization of GM atrophy between the hippocampus and other regions.”
Background
- Authors
- Convit, A., De Leon, M. J., Tarshish, C., De Santi, S., Tsui, W., Rusinek, H., & George, A.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- NYU Langone Health (US)
- Corresponding author
- Convit, A.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 18
- Issue
- 2
- Pages
- 131-138
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2165278596
- Cited by
- 427
- References
- 53
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 7 · 2023: 12 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 7 · 2016: 13 · 2015: 17 · 2014: 24 · 2013: 15 · 2012: 21
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurobiology of Aging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P30 AG08051, AG12101, AG08051)
- National Institute on Aging (P30 AG 08051, AG03051, R01AG003051, P30AG008051, R01AG013616, AG 13616)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, hippocampal volume, preclinical dementia, temporal lobe atrophy, fusiform gyrus, lateral temporal lobe, medial temporal lobe, brain atrophy, volumetric MRI, dementia risk
- MeSH terms
- Aged, Alzheimer Disease, Cognition Disorders, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Psychometrics, Risk, Temporal Lobe, Observer Variation
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