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Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease
Abstract
Microelectrode recording methods for stereotactic localization of the subthalamic nucleus (STN) and surrounding structures are described. These methods accurately define targets for chronic deep brain stimulation in the treatment of Parkinson's disease. Mean firing rates and a burst index were determined for all recorded neurons, and responses to active and passive limb and orofacial movements were tested. STN neurons had a mean firing rate of 37 ± 17 Hz (n = 248) and an irregular firing pattern (median burst index, 3.3). Movement‐related activity and tremor cells were identified in the STN. Ventral to the STN, substantia nigra pars reticulata neurons had a mean rate of 71 ± 23 Hz (n = 56) and a more regular firing pattern (median burst index, 1.7). Short trains (1–2 seconds) of electrical microstimulation of STN could produce tremor arrest but were and found to be useful for localization. Compared with data from normal monkeys our findings suggest that STN neuronal activity is elevated in Parkinson's disease.
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Citations
Cited by
Subthalamic nucleus stimulation in severe obsessive-compulsive disorder
Mallet, L., Polosan, M., Jaafari, N., Baup, N., Welter, M.-L., Fontaine, D., Montcel, S. T. D., Yelnik, J., Chéreau, I., Arbus, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708514 · Cited by 965
Benedetti, F., Pollo, A., Lopiano, L., Lanotte, M., Vighetti, S., & Rainero, I. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04315.2003 · Cited by 788
LeWitt, P. A., Rezai, A. R., Leehey, M. A., Ojemann, S. G., Flaherty, A. W., Eskandar, E. N., Kostyk, S. K., Thomas, K., Sarkar, A., Siddiqui, M. S., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70039-4 · Cited by 681
Probing and regulating dysfunctional circuits using deep brain stimulation
Lozano, A. M., & Lipsman, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.020 · Cited by 665
Self-citationThe cerebral oscillatory network of parkinsonian resting tremor
Timmermann, L., Gross, J., Dirks, M., Volkmann, J., Freund, H.-J., & Schnitzler, A. (2003) · Brain · doi:10.1093/brain/awg022 · Cited by 544
Williams, D. (2002) · Brain · doi:10.1093/brain/awf156 · Cited by 513
Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients
Magnin, M., Morel, A., & Jeanmonod, D. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00583-7 · Cited by 396
The Cerebellum and Basal Ganglia are Interconnected
Bostan, A. C., & Strick, P. L. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9143-9 · Cited by 371
Subthalamic GAD Gene Therapy in a Parkinson's Disease Rat Model
Luo, J., Kaplitt, M. G., Fitzsimons, H. L., Zuzga, D. S., Liu, Y., Oshinsky, M. L., & During, M. J. (2002) · Science · doi:10.1126/science.1074549 · Cited by 325
Stefurak, T., Mikulis, D., Mayberg, H., Lang, A. E., Hevenor, S., Pahapill, P., Saint‐Cyr, J., & Lozano, A. (2003) · Movement Disorders · doi:10.1002/mds.10593 · Cited by 215
Self-citationDefective cortical drive to muscle in Parkinson's disease and its improvement with levodopa
Salenius, S., Avikainen, S., Kaakkola, S., Hari, R., & Brown, P. (2002) · Brain · doi:10.1093/brain/awf042 · Cited by 180
Welter, M.-L., Burbaud, P., Fernandez-Vidal, S., Bardinet, E., Coste, J., Piallat, B., Borg, M., Besnard, S., Sauleau, P., Devaux, B., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.5 · Cited by 160
“Extracellular single-unit neuronal activity was recorded simultaneously from 3 to 5 leads, used to identify and localise the STN for 2 min at rest, each 200–500mm within the STN.31,32 Off-line analysis.”
MethodHigh-density single-unit human cortical recordings using the Neuropixels probe
Chung, J. E., Sellers, K. K., Leonard, M. K., Gwilliams, L., Xu, D., Dougherty, M. E., Kharazia, V., Metzger, S. L., Welkenhuysen, M., Dutta, B., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.007 · Cited by 126
Richter, E. O., Davis, K. D., Hamani, C., Hutchison, W. D., Dostrovsky, J. O., & Lozano, A. M. (2004) · Neurosurgery · doi:10.1227/01.neu.0000108644.42992.95 · Cited by 69
Self-citationHe, X., Hao, M.-Z., Wei, M., Xiao, Q., & Lan, N. (2015) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-015-0101-x · Cited by 18
Metadata
- Authors
- Hutchison, W. D., Allan, R. J., Opitz, H., Levy, R., Dostrovsky, J. O., Lang, A. E., & Lozano, A. M.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1998-10
- Volume
- 44
- Issue
- 4
- Pages
- 622-628
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2108157570
- Cited by
- 702
- References
- 0
- FWCI
- 20.22
- Type
- journal article
- Language
- en
- Open access
- closed
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