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Solid Phase Synthesis (Nobel Lecture)
Abstract
A solid phase as “protecting group” in peptide synthesis—this was the original idea of Bruce Merrifield, who received the 1984 Nobel Prize for Chemistry. In his lecture, he describes the development of the Merrifield synthesis. In principle, all difunctional educts that may be selectively protected at one end and activated at the other can undergo reactions on solid supports.
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Citations
Cited by
N -Methylated Cyclic RGD Peptides as Highly Active and Selective α V β 3 Integrin Antagonists
Dechantsreiter, M. A., Planker, E., Mathä, B., Lohof, E., Hölzemann, G., Jonczyk, A., Goodman, S. L., & Kessler, H. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm970832g · Cited by 838
50th Anniversary Perspective: Block Polymers—Pure Potential
Bates, C. M., & Bates, F. S. (2017) · Macromolecules · doi:10.1021/acs.macromol.6b02355 · Cited by 788
Giernoth, R. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200905981 · Cited by 746
At the Crossroads of Chemistry and Immunology: Catalytic Antibodies
Lerner, R. A., Benkovic, S. J., & Schultz, P. G. (1991) · Science · doi:10.1126/science.2024118 · Cited by 668
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Metadata
- Authors
- Merrifield, R. B.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1985-10
- Volume
- 24
- Issue
- 10
- Pages
- 799-810
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2104160688
- Cited by
- 365
- References
- 0
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Solid Phase Synthesis (Nobel Lecture). https://app.cochat.ai/papers/10.1002/anie.198507993
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- Merrifield, R. B. (1985). Solid Phase Synthesis (Nobel Lecture). Angewandte Chemie International Edition in English. https://doi.org/10.1002/anie.198507993
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
