The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
At the Crossroads of Chemistry and Immunology: Catalytic Antibodies
Abstract
Immunochemistry has historically focused on the nature of antigenicity and antibody-antigen recognition. However, in the last 5 years, the field of immunochemistry has taken a new direction. With the aid of mechanistic and synthetic chemistry, the vast network of molecules and cells of the immune system has been tapped to produce antibodies with a new function—catalytic antibodies. Because antibodies can be generated that selectively bind almost any molecule of interest, this new technology offers the potential to tailor-make highly selective catalysts for applications in biology, chemistry, and medicine. In addition, catalytic antibodies provide fundamental insight into important aspects of biological catalysis, including the importance of transition-state stabilization, proximity effects, general acid and base catalysts, electrophilic and nucleophilic catalysis, and strain.
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Citations
Cites
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Cited by
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Metadata
- Authors
- Lerner, R. A., Benkovic, S. J., & Schultz, P. G.
- Venue
- Science
- Published
- 1991-05-03
- Volume
- 252
- Issue
- 5006
- Pages
- 659-667
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043582941
- Cited by
- 668
- References
- 35
- FWCI
- 57.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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