The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
A Chemical Approach to Protein Design—Template‐Assembled Synthetic Proteins (TASP)
Open accessAbstract
Advances in methodology in both chemistry and molecular biology allow us to take a fresh look at protein science. Chemical synthesis of peptides and site‐directed mutagenesis are now standard research tools, paving the way for the construction of new proteins with tailor‐made structural and functional properties. The decisive hurdle on the way lies not in the synthesis of the molecules proper but rather in a better understanding of the complex folding pathways of polypeptide chains into spatially well‐defined structures. Can the chemist use his synthetic tools to bypass the notorious “folding problem?” In this article, we present a new approach developed in our laboratory, which opens a chemical route to artificial proteins with predetermined three‐dimensional structures, allowing a first step towards the synthesis of new proteins with functional properties.
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Citations
Cites
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Wüthrich, K. (1986) · Europhysics News · doi:10.1051/epn/19861701011 · Cited by 7,989
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Merrifield, R. B. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00897a025 · Cited by 7,647
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Cited by
Tomalia, D. A., Naylor, A. M., & Goddard, W. A. (1990) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199001381 · Cited by 3,211
Seebach, D. (1990) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199013201 · Cited by 577
Poly(hydroxyalkanoates): A Fifth Class of Physiologically Important Organic Biopolymers?
Müller, H., & Seebach, D. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199304771 · Cited by 363
Pseudo-Prolines as a Solubilizing, Structure-Disrupting Protection Technique in Peptide Synthesis
Wöhr, T., Wahl, F., Nefzi, A., Rohwedder, B., Sato, T., Sun, X., & Mutter, M. (1996) · Journal of the American Chemical Society · doi:10.1021/ja961509q · Cited by 345
Self-citationHeimgartner, H. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199102381 · Cited by 253
Metadata
- Authors
- Mutter, M., & Vuilleumier, S.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1989-05
- Volume
- 28
- Issue
- 5
- Pages
- 535-554
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2072628378
- Cited by
- 400
- References
- 179
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
