The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
Abstract
Starburst dendrimers are three‐dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol. Protecting group strategies are crucial in these syntheses, which proceed via discrete “Aufbau” stages referred to as generations. Critical molecular design parameters (CMDPs) such as size, shape, and surface chemistry may be controlled by the reactions and synthetic building blocks used. Starburst dendrimers can mimic certain properties of micelles and liposomes and even those of biomolecules and the still more complicated, but highly organized, building blocks of biological systems. Numerous applications of these compounds are conceivable, particularly in mimicking the functions of large biomolecules as drug carriers and immunogens. This new branch of “supramolecular chemistry” should spark new developments in both organic and macromolecular chemistry.
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Citations
Cites
Principles that Govern the Folding of Protein Chains
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Tam, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5409 · Cited by 1,251
Cited by
Design and development of polymers for gene delivery
Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1775 · Cited by 2,568
Self‐Assembly in Natural and Unnatural Systems
Philp, D., & Stoddart, J. F. (1996) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199611541 · Cited by 2,115
Dendrimers in biomedical applications—reflections on the field
SVENSON, S., & TOMALIA, D. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.018 · Cited by 1,919
Self-citationPolyamidoamine cascade polymers mediate efficient transfection of cells in culture
Haensler, J., & Szoka, F. C. (1993) · Bioconjugate Chemistry · doi:10.1021/bc00023a012 · Cited by 1,207
Tomalia, D. A. (2005) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2005.01.007 · Cited by 1,115
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Metadata
- Authors
- Tomalia, D. A., Naylor, A. M., & Goddard, W. A.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1990-02
- Volume
- 29
- Issue
- 2
- Pages
- 138-175
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2168206768
- Cited by
- 3,211
- References
- 4
- FWCI
- 55.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter. https://app.cochat.ai/papers/10.1002/anie.199001381
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- Tomalia, D. A., Naylor, A. M., & Goddard, W. A. (1990). Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter. Angewandte Chemie International Edition in English. https://doi.org/10.1002/anie.199001381
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