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A “Smart” Magnetic Resonance Imaging Agent That Reports on Specific Enzymatic Activity
Abstract
A noninvasive means to map biological structure is offered by magnetic resonance imaging (MRI). A new class of MRI contrast agents is described where the relaxivity of the complex is modified by the activity of a specific enzyme (β-galactosidase, [Eq. (a)]). This type of agent offers the promise of direct three-dimensional visualization of gene expression in the form of an acquired MR image.
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Cited by
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Caravan, P., Ellison, J. J., McMurry, T. J., & Lauffer, R. B. (1999) · Chemical Reviews · doi:10.1021/cr980440x · Cited by 4,483
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,061
Shedding light onto live molecular targets
Weissleder, R., & Ntziachristos, V. (2003) · Nature Medicine · doi:10.1038/nm0103-123 · Cited by 1,909
Magnetic nanoparticles for drug delivery
Arruebo, M., Fernández-Pacheco, R., Ibarra, M. R., & Santamaría, J. (2007) · Nano Today · doi:10.1016/s1748-0132(07)70084-1 · Cited by 1,613
Weissleder, R., & Mahmood, U. (2001) · Radiology · doi:10.1148/radiology.219.2.r01ma19316 · Cited by 1,315
Metadata
- Authors
- Moats, R. A., Fraser, S. E., & Meade, T. J.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1997-04-18
- Volume
- 36
- Issue
- 7
- Pages
- 726-728
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2022558454
- Cited by
- 330
- References
- 0
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A “Smart” Magnetic Resonance Imaging Agent That Reports on Specific Enzymatic Activity. https://app.cochat.ai/papers/10.1002/anie.199707261
- The paper
- Moats, R. A., Fraser, S. E., & Meade, T. J. (1997). A “Smart” Magnetic Resonance Imaging Agent That Reports on Specific Enzymatic Activity. Angewandte Chemie International Edition in English. https://doi.org/10.1002/anie.199707261
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
