Cited by 1,315Medical Imaging Techniques and ApplicationsRadiopharmaceutical Chemistry and ApplicationsOptical Imaging and Spectroscopy Techniques

Molecular Imaging

Weissleder, Ralph, Mahmood, Umar·2001·Radiology

Abstract

The term molecular imaging can be broadly defined as the in vivo characterization and measurement of biologic processes at the cellular and molecular level. In contradistinction to "classical" diagnostic imaging, it sets forth to probe the molecular abnormalities that are the basis of disease rather than to image the end effects of these molecular alterations. While the underlying biology represents a new arena for many radiologists, concomitant efforts such as development of novel agents, signal amplification strategies, and imaging technologies clearly dovetail with prior research efforts of our specialty. Radiologists will play a leading role in directing developments of this embryonic but burgeoning field. This article presents some recent developments in molecular sciences and medicine and shows how imaging can be used, at least experimentally, to assess specific molecular targets. In the future, specific imaging of such targets will allow earlier detection and characterization of disease, earlier and direct molecular assessment of treatment effects, and a more fundamental understanding of the disease process.

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Crossref · 10.1148/radiology.219.2.r01ma19316

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129 of 129 references verified0 citation errors · 0 not checkable

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  • Developments in molecular imaging allow characterization of biological processes in cardiovascular disease at the cellular and molecular level.

    “Developments in the field of molecular imaging allow the characterization of biological processes in cardiovascular disease at the cellular and molecular level117.”

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Authors
Weissleder, R., & Mahmood, U.
Affiliations
Harvard University (US)
Venue
Radiology
Published
2001-05
Volume
219
Issue
2
Pages
316-333
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
OpenAlex
W4211128641
Cited by
1,315
References
129
Citations by year
2026: 12 · 2025: 29 · 2024: 31 · 2023: 28 · 2022: 43 · 2021: 51 · 2020: 50 · 2019: 28 · 2018: 48 · 2017: 43 · 2016: 53 · 2015: 39 · 2014: 45 · 2013: 63 · 2012: 61
FWCI
8.72
Type
journal article
Language
en
Open access
closed
Locations
  • Radiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Keywords
molecular imaging, molecular imaging agents, signal amplification, molecular targets, early disease detection, treatment response assessment
MeSH terms
Animals, Genetic Markers, Genetic Techniques, Humans, Magnetic Resonance Imaging, Microradiography, Molecular Biology, Radionuclide Imaging, Genetic Therapy, Molecular Probe Techniques, Gene Expression Profiling

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