The DOI matches its Crossref record; 361 of the 361 references it cites were found in a registry or an index.
Chemistry and Biology of DNA Repair
Abstract
Numerous agents of endogenous and exogenous origin damage DNA in our genome. There are several DNA‐repair pathways that recognize lesions in DNA and remove them through a number of diverse reaction sequences. Defects in DNA‐repair proteins are associated with several human hereditary syndromes, which show a marked predisposition to cancer. Although DNA repair is essential for a healthy cell, DNA‐repair enzymes counteract the efficiency of a number of important antitumor agents that exert their cytotoxic effects by damaging DNA. DNA‐repair enzymes are therefore also targets for drug design. DNA‐repair processes differ greatly in their nature and complexity. Whereas some pathways only require a single enzyme to restore the original DNA sequence, others operate through the coordinated action of 30 or more proteins. Our understanding of the genetic, biochemical, and structural basis of DNA repair and related processes has increased dramatically over the past decade. This review summarizes the latest developments in this field.
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2 retracted
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RetractedRETRACTED: Transcription-Coupled Repair of 8-oxoGuanine
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RetractedInstability and decay of the primary structure of DNA
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Genome maintenance mechanisms for preventing cancer
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The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213
Structure, Recognition, and Processing of Cisplatin−DNA Adducts
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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
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Cited by
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642
Self-citationDNA damage by reactive species: Mechanisms, mutation and repair
Jena, N. R. (2012) · Journal of Biosciences · doi:10.1007/s12038-012-9218-2 · Cited by 344
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Zhirnov, V., Zadegan, R. M., Sandhu, G. S., Church, G. M., & Hughes, W. L. (2016) · Nature Materials · doi:10.1038/nmat4594 · Cited by 307
Nuclear and mitochondrial DNA repair: similar pathways?
Larsen, N. B., Rasmussen, M., & Rasmussen, L. J. (2005) · Mitochondrion · doi:10.1016/j.mito.2005.02.002 · Cited by 289
Metadata
- Authors
- Schärer, O. D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2003-07-02
- Volume
- 42
- Issue
- 26
- Pages
- 2946-2974
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2009041655
- Cited by
- 381
- References
- 361
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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