The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Natural Product Hybrids as New Leads for Drug Discovery
Abstract
Natural products play an important role in the development of drugs, especially for the treatment of infections and cancer, as well as immunosuppressive compounds. However, the number of natural products is limited, whereas millions of hybrids as combinations of parts of different natural products can be prepared. This new approach seems to be very promising in the development of leads for both medicinal and agrochemical applications, as the biological activity of several new hybrids exceeds that of the parent compounds. The advantage of this concept over a combinatorial chemistry approach is the high diversity and the inherent biological activity of the hybrids.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery
Schreiber, S. L. (2000) · Science · doi:10.1126/science.287.5460.1964 · Cited by 2,568
Zagrean, L. (2014) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2014.529 · Cited by 1,909
Natural Products in Drug Discovery and Development
Cragg, G. M., Newman, D. J., & Snader, K. M. (1997) · Journal of Natural Products · doi:10.1021/np9604893 · Cited by 1,585
Synthesis and Applications of Small Molecule Libraries
Thompson, L. A., & Ellman, J. A. (1996) · Chemical Reviews · doi:10.1021/cr9402081 · Cited by 1,452
HULTMARK, D., STEINER, H., RASMUSON, T., & BOMAN, H. G. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb05991.x · Cited by 1,008
Chemistry and Biology of the Enediyne Anticancer Antibiotics
Nicolaou, K. C., & Dai, W. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199113873 · Cited by 991
Appel, R. (1975) · Angewandte Chemie International Edition in English · doi:10.1002/anie.197508011 · Cited by 943
Annonaceous Acetogenins: Recent Progress
Alali, F. Q., Liu, X.-X., & McLaughlin, J. L. (1999) · Journal of Natural Products · doi:10.1021/np980406d · Cited by 818
Coll, M., Frederick, C. A., Wang, A. H., & Rich, A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8385 · Cited by 684
Inhibitors of NADH–ubiquinone reductase: an overview
Degli Esposti, M. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00029-2 · Cited by 528
Cited by
Hybrid molecules: The privileged scaffolds for various pharmaceuticals
Shaveta, Mishra, S., & Singh, P. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.08.039 · Cited by 508
In situ click chemistry: probing the binding landscapes of biological molecules
Mamidyala, S. K., & Finn, M. G. (2010) · Chemical Society Reviews · doi:10.1039/b901969n · Cited by 489
Nepali, K., Sharma, S., Sharma, M., Bedi, P. M. S., & Dhar, K. L. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.03.018 · Cited by 435
Exploitation of marine algae: biogenic compounds for potential antifouling applications
Bhadury, P., & Wright, P. (2004) · Planta · doi:10.1007/s00425-004-1307-5 · Cited by 327
Current Perspectives in the Application of Medicinal Plants Against Cancer: Novel Therapeutic Agents
Gezici, S., & Şekeroğlu, N. (2019) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520619666181224121004 · Cited by 258
Metadata
- Authors
- Tietze, L. F., Bell, H. P., & Chandrasekhar, S.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2003-09-05
- Volume
- 42
- Issue
- 34
- Pages
- 3996-4028
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2117048089
- Cited by
- 516
- References
- 59
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Natural Product Hybrids as New Leads for Drug Discovery. https://app.cochat.ai/papers/10.1002/anie.200200553
- The paper
- Tietze, L. F., Bell, H. P., & Chandrasekhar, S. (2003). Natural Product Hybrids as New Leads for Drug Discovery. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200200553
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
