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Annonaceous Acetogenins: Recent Progress
Abstract
The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.
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Cited by
Moghadamtousi, S., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H., & Kadir, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715625 · Cited by 577
Coria-Téllez, A. V., Montalvo-Gónzalez, E., Yahia, E. M., & Obledo-Vázquez, E. N. (2018) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2016.01.004 · Cited by 532
Zhang, Z., Liu, C., Kinder, R. E., Han, X., Qian, H., & Widenhoefer, R. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja062045r · Cited by 459
Gavamukulya, Y., Wamunyokoli, F., & El-Shemy, H. A. (2017) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2017.08.009 · Cited by 174
A Review on Annona muricata and Its Anticancer Activity
Ilango, S., Sahoo, D. K., Paital, B., Kathirvel, K., Gabriel, J. I., Subramaniam, K., Jayachandran, P., Dash, R. K., Hati, A. K., Behera, T. R., et al. (2022) · Cancers · doi:10.3390/cancers14184539 · Cited by 91
Metadata
- Authors
- Alali, F. Q., Liu, X.-X., & McLaughlin, J. L.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-03-01
- Volume
- 62
- Issue
- 3
- Pages
- 504-540
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2142576295
- Cited by
- 818
- References
- 0
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Alali, F. Q., Liu, X.-X., & McLaughlin, J. L. (1999). Annonaceous Acetogenins: Recent Progress. Journal of Natural Products. https://doi.org/10.1021/np980406d
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
