The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Chemistry and Biology of Roseophilin and the Prodigiosin Alkaloids: A Survey of the Last 2500 Years
Abstract
The pyrrole alkaloids of the prodigiosin family make up an unusual chapter in the chemistry of natural products. Owing to the characteristic red color of these secondary metabolites, colonies of the Gram‐negative‐producing bacteria may strikingly resemble droplets of blood. This phenomenon caused considerable confusion in the past and was likely responsible for many seemingly miraculous (prodigious) events. After the eventual transition from superstition to science, the prodigiosins started to attract considerable attention because of their promising physiological properties. Most interesting are the immunosuppressive activities at doses that are not cytotoxic, in particular since in vivo studies suggest that the prodigiosins act synergistically with cyclosporine A or FK 506, which are presently the dominant drugs in clinical immunosuppressive regimens. Furthermore, the chemistry of the closely related and structurally rather unique alkaloid roseophilin is summarized, a cytotoxic agent that recently became the focal point of many innovative total syntheses.
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Nicolaou, K. C., Bulger, P. G., & Sarlah, D. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200500368 · Cited by 2,708
Catalytic Carbophilic Activation: Catalysis by Platinum and Gold π Acids
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Self-citationApplications of Supramolecular Anion Recognition
Busschaert, N., Caltagirone, C., Van Rossom, W., & Gale, P. A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00099 · Cited by 1,249
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Metadata
- Authors
- Fürstner, A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2003-08-07
- Volume
- 42
- Issue
- 31
- Pages
- 3582-3603
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2150969390
- Cited by
- 827
- References
- 58
- FWCI
- 19.70
- Type
- journal article
- Language
- en
- Open access
- closed
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