Cited by 107Origins and Evolution of LifeAsymmetric Synthesis and CatalysisChemical Reaction Mechanisms

Serine Octamer Reactions: Indicators of Prebiotic Relevance

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Takats, Zoltan, Nanita, Sergio C., Cooks, R. Graham·2003·Angewandte Chemie International Edition

Abstract

The earliest molecule of life? Chirally selective reactions relevant to the origin of homochiral life are undergone by serine. Chiral exchange between serine, glyceraldehyde, and glucose occurs, favoring the enantiomers (L-serine, D-sugars) present in modern living systems (see picture).

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Crossref · 10.1002/anie.200351210

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21 of 21 references verified0 citation errors · 0 not checkable

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  • (S)-Ser in these octamers can be substituted enantiospecifically by prebiotic molecules (notably D-sugars).

    “Moreover, (S)-Ser in these octamers can be substituted enantiospecifically by prebiotic molecules (notably D-sugars)”

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Authors
Takats, Z., Nanita, S. C., & Cooks, R. G.
Affiliations
Purdue University West Lafayette (US)
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2003-07-30
Volume
42
Issue
30
Pages
3521-3523
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2090276084
Cited by
107
References
21
Citations by year
2025: 1 · 2024: 1 · 2022: 5 · 2021: 7 · 2020: 3 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 8
FWCI
8.68
Type
journal article
Language
en
Open access
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Physical Sciences › Chemistry › Organic Chemistry › Asymmetric Synthesis and Catalysis
  • Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
Keywords
serine, prebiotic chemistry, origin of homochirality, chirality, glyceraldehyde, glucose, L-serine, enantiomers, origin of life
MeSH terms
Glucose, Glyceraldehyde, Indicators and Reagents, Serine, Evolution, Chemical, Spectrometry, Mass, Electrospray Ionization

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