Serine Octamer Reactions: Indicators of Prebiotic Relevance
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The earliest molecule of life? Chirally selective reactions relevant to the origin of homochiral life are undergone by serine. Chiral exchange between serine, glyceraldehyde, and glucose occurs, favoring the enantiomers (L-serine, D-sugars) present in modern living systems (see picture).
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(S)-Ser in these octamers can be substituted enantiospecifically by prebiotic molecules (notably D-sugars).
“Moreover, (S)-Ser in these octamers can be substituted enantiospecifically by prebiotic molecules (notably D-sugars)”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [545]
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- Authors
- Takats, Z., Nanita, S. C., & Cooks, R. G.
- Affiliations
- Purdue University West Lafayette (US)
- ORCID
- Cooks, R. Graham
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2003-07-30
- Volume
- 42
- Issue
- 30
- Pages
- 3521-3523
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2090276084
- Cited by
- 107
- References
- 21
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 5 · 2021: 7 · 2020: 3 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 8
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Chemistry › Organic Chemistry › Asymmetric Synthesis and Catalysis
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Keywords
- serine, prebiotic chemistry, origin of homochirality, chirality, glyceraldehyde, glucose, L-serine, enantiomers, origin of life
- MeSH terms
- Glucose, Glyceraldehyde, Indicators and Reagents, Serine, Evolution, Chemical, Spectrometry, Mass, Electrospray Ionization
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